Genetic studies of nonsyndromic clefts in populations of African Descent.

项目摘要 候选人：Azeez Butali博士是卡弗学院的博士后研究学者。 医学，爱荷华州大学。他的主要研究重点是遗传学和流行病学 包括口面裂在内的复杂颅面疾病他的短期职业目标是 加深他对复杂颅面特征（如口面裂）遗传学的了解， 扩大目前的分子技术的理解，以评估这些性状。他的长期 目标是成为颅面遗传学领域的独立科学家， 牙科作为大学终身教职教师。他的研究计划是创新性的， 遗传学技术调查非洲人群口面裂的遗传病因 了解这些复杂的特征。这项研究将利用样本 通过国际遗传流行病学联盟在颅面 研究中心（CARC），爱荷华州大学。这项研究有可能发现新的 生物途径参与口面裂，并将提供新的信息， 临床裂缝亚表型与全基因组关联产生的显著SNP之间的关系 问题研究它也有可能对口腔颌面部的管理产生直接的临床影响 裂缝导师和顾问：Jeffrey Murray博士将担任该奖项的主要导师。 他是爱荷华州大学资金充足的正教授，拥有25年的培训经验 成功的研究生和博士后学生。安德鲁·利德拉尔博士，在该领域的专家 颅面遗传学博士将担任该奖项的共同导师。玛丽·马拉齐塔和阿德波瓦勒博士 Adeyemo将作为该项目的顾问，提供临床和统计遗传学数据， 专业知识彼得·莫西博士、保罗·罗米蒂博士和乔治·韦比博士将担任外部顾问 委员会成员，并将在整个会议期间与Butali博士协商，提供咨询意见和评估他的进展情况。 他们在颅面遗传学，流行病学， 牙科和基因组分析。环境：爱荷华州大学有一个既定的 成功培养研究生和博士后学生的声誉，特别是在 研究和临床领域。大学提供一系列的学习和发展研讨会 以及其他专注于职业发展和进步的项目，特别是 受益于ICTS（临床和翻译研究所）提供的培训机会 科学）由CTSA奖支持。职业发展计划：Butali博士计划与 定期与他的导师，顾问和外部咨询成员，以获得知识， 必要的，以获得他的职业和研究目标，以及参加教程，课程， 研讨会和相关会议。研究性学习：本研究的重点是了解 复杂的遗传病因学的口面裂，通过确定遗传变异， 并将这些发现与预防和临床 疾病的管理。

PROJECT SUMMARY Candidate: Dr Azeez Butali is a Postdoctoral Research Scholar at the Carver College of Medicine, the University of Iowa. His primary research focus is on the genetics and epidemiology of complex craniofacial disorders including orofacial clefts. His short-term career goals are to deepen his knowledge of the genetics of complex craniofacial traits such as orofacial clefts and expand current understanding of molecular techniques to evaluate these traits. His long-term goals are to become a funded independent scientist in the fields of craniofacial genetics and dentistry as tenure-track faculty at a University. His research plan is innovative in using molecular genetic techniques to investigate the genetic etiology of orofacial clefts in populations of African ancestry in other to understand these complex traits. This research will utilize the samples obtained through the International Genetic Epidemiology Consortium at the Craniofacial Research Center (CARC), University of Iowa. This research has the potential of identifying new biological pathways involved in orofacial clefts and will provide new information on correlation between clinical cleft sub-phenotypes and significant SNPs arising from genome wide association studies. It also has the potential of having direct clinical impact on the management of orofacial clefts. Mentors and Consultants: Dr. Jeffrey Murray will serve as primary mentor on this award. He is a well-funded full professor at the University of Iowa with 25 years of experience in training successful graduate and postdoctoral students. Dr. Andrew Lidral, an expert in the field of craniofacial genetics, will serve as co-mentor to this award. Drs. Mary Marazita and Adebowale Adeyemo will serve as consultants on this project by providing clinical and statistical genetic expertise. Drs. Peter Mossey, Paul Romitti and George Wehby will serve as external advisory members and will consult with, advice and evaluate the progress of Dr. Butali throughout the award period and they have complementary expertise in the craniofacial genetics, epidemiology, dentistry and genomic analysis. Environment: The University of Iowa has an established reputation for the successful training of graduate and postdoctoral students, particularly in research and clinical areas. The University offers a range of learning and development seminars as well as other programs focused on career development and advancement, and particularly benefits from training opportunities deriving from its ICTS (Institute for Clinical and Translational Sciences) support by a CTSA award. Career Development Plan: Dr. Butali plans to meet regularly with his mentors, consultants and external advisory members to gain the knowledge necessary to obtain his career and research goals as well as attending tutorials, courses, seminars and relevant conferences. Research Study: The focus of this study is to understand the complex genetic etiology of orofacial clefts by determining the genetic variations that contributes to it in homogenous African populations and relate these findings to prevention and clinical management of the disease.