Head and Neck squamous cell carcinoma radiation response modulation by HPV

HPV 调节头颈鳞状细胞癌放射反应

基本信息

  • 批准号:
    8165405
  • 负责人:
  • 金额:
    $ 14.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-05 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Human papillomavirus (HPV) associated head and neck cancer is a growing public health concern. These patients commonly present at a younger age and with more advanced stage disease than patients with traditional tobacco and alcohol associated head and neck squamous cell carcinoma (HNSCC). Paradoxically, these HPV-associated tumors show notably improved survival outcomes. Mechanisms underlying these improved outcomes remain unclear. The work proposed in this Pathways to Independence Award has two primary goals: 1) to facilitate career development of the principal investigator (PI) and to help establish his independence to lead a research program investigating radiation response in virally associated cancers; and, 2) to understand how HPV-associated HNSCC differs from traditional HNSCC in response to radiation and chemotherapy. During the mentored phase of research, the PI will obtain additional training in molecular virology, human papillomavirus biology, and mouse models of cancer. The research conducted during the mentored phase will examine why HPV-associated HNSCC are more sensitive than traditional HNSCC to radiation and chemotherapy and to examine the ability of epidermal growth factor receptor (EGFR) inhibitors to sensitize HPV-associated head and neck cancer to radiation despite low levels of EGFR expression. During the independent phase, research will examine the impact of HPV viral proteins on EGFR inhibitor-mediated radiosensitization and the impact of EGFR loss on radiosensitization strategies. These studies will provide new clues regarding mechanisms of increased sensitivity to radiation and chemotherapy and may identify important new targets for therapy development to further improve outcome for patients with both HPV-associated and non-HPV-associated head and neck cancer. PUBLIC HEALTH RELEVANCE: Head and neck squamous cell carcinomas associated with human papillomavirus (HPV) infection are rapidly increasing in global incidence, often present at an advanced stage, are commonly treated with radiation and chemotherapy, and generally show an improved prognosis; nevertheless, selection of optimal therapy remains ill defined. This proposal investigates molecular mechanisms of treatment response with a goal to identify novel means of radiosensitization, the relationship between epidermal growth factor receptor (EGFR) signaling and radiosensitivity, and potential novel mechanisms of radiosensitization. The ultimate objective is to design rationale combinations of radiation and chemotherapy to further improve outcome and/or decrease treatment toxicity.
描述(由申请人提供):人乳头瘤病毒(HPV)相关的头颈癌是一个日益增长的公共卫生问题。这些患者通常比传统的烟草和酒精相关的头颈部鳞状细胞癌(HNSCC)患者年龄更小,疾病更晚期。奇怪的是,这些HPV相关肿瘤显示出显著改善的生存结局。这些改善结果的机制仍不清楚。这项独立之路奖中提出的工作有两个主要目标:1)促进主要研究者(PI)的职业发展,并帮助建立他的独立性,以领导一项研究病毒相关癌症的放射反应的研究计划; 2)了解HPV相关HNSCC与传统HNSCC在放射和化疗反应方面的差异。在研究的指导阶段,PI将获得分子病毒学,人乳头瘤病毒生物学和小鼠癌症模型的额外培训。在指导阶段进行的研究将检查为什么HPV相关的HNSCC比传统的HNSCC对放疗和化疗更敏感,并检查表皮生长因子受体(EGFR)抑制剂使HPV相关的头颈癌对放疗敏感的能力,尽管EGFR表达水平较低。在独立阶段,研究将检查HPV病毒蛋白对EGFR受体介导的放射增敏作用的影响以及EGFR丢失对放射增敏策略的影响。这些研究将提供关于对放疗和化疗敏感性增加的机制的新线索,并可能为治疗开发确定重要的新靶点,以进一步改善HPV相关和非HPV相关头颈癌患者的预后。 公共卫生关系:与人乳头瘤病毒(HPV)感染相关的头颈部鳞状细胞癌在全球发病率迅速增加,通常出现在晚期,通常采用放疗和化疗治疗,并且通常显示出改善的预后;然而,最佳治疗的选择仍然不明确。该提案研究了治疗反应的分子机制,目的是确定放射增敏的新方法,表皮生长因子受体(EGFR)信号传导与放射敏感性之间的关系,以及放射增敏的潜在新机制。最终目的是设计合理的放疗和化疗组合,以进一步改善结局和/或降低治疗毒性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

RANDALL J KIMPLE其他文献

RANDALL J KIMPLE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('RANDALL J KIMPLE', 18)}}的其他基金

Planning a phase I study of minor salivary gland derived autologous MSCs for prevention of long-term radiation induced xerostomia
计划对小唾液腺来源的自体 MSC 进行 I 期研究,以预防长期辐射引起的口干症
  • 批准号:
    10720234
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
Intra-salivary gland autotransplantation of marrow mesenchymal stromal cells for treatment of radiation induced xerostomia
唾液腺内自体骨髓间充质干细胞移植治疗放射引起的口干症
  • 批准号:
    10793666
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
提高头颈癌小鼠模型的转化价值
  • 批准号:
    10598311
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
提高头颈癌小鼠模型的转化价值
  • 批准号:
    10442585
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Intra-salivary gland autotransplantation of marrow mesenchymal stromal cells for treatment of radiation induced xerostomia
唾液腺内自体骨髓间充质干细胞移植治疗放射引起的口干症
  • 批准号:
    10187170
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
提高头颈癌小鼠模型的转化价值
  • 批准号:
    10737804
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
提高头颈癌小鼠模型的转化价值
  • 批准号:
    10652384
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
提高头颈癌小鼠模型的转化价值
  • 批准号:
    10298211
  • 财政年份:
    2021
  • 资助金额:
    $ 14.9万
  • 项目类别:
Head and Neck squamous cell carcinoma radiation response modulation by HPV
HPV 调节头颈鳞状细胞癌放射反应
  • 批准号:
    8604213
  • 财政年份:
    2013
  • 资助金额:
    $ 14.9万
  • 项目类别:
Head and Neck squamous cell carcinoma radiation response modulation by HPV
HPV 调节头颈鳞状细胞癌放射反应
  • 批准号:
    8628797
  • 财政年份:
    2013
  • 资助金额:
    $ 14.9万
  • 项目类别:

相似海外基金

Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
  • 批准号:
    2304861
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Continuing Grant
STTR Phase I: Development of Modular Reactors to Convert Methane to Alcohols at Low Temperatures
STTR 第一阶段:开发在低温下将甲烷转化为醇的模块化反应器
  • 批准号:
    2151256
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Standard Grant
Development of amine-dehydrogenase and lyase biocatalysts for the sustainable manufacturing of unnatural chiral amino acids and amino alcohols
开发胺脱氢酶和裂解酶生物催化剂,用于可持续生产非天然手性氨基酸和氨基醇
  • 批准号:
    2870226
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Studentship
Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
  • 批准号:
    2304860
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Continuing Grant
Postdoctoral Fellowship: MPS-Ascend: Development of Selective Reaction Schemes for Photoactivation of Alcohols
博士后奖学金:MPS-Ascend:醇光活化选择性反应方案的开发
  • 批准号:
    2316541
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Fellowship Award
Development of phosphorylation of alcohols in protein based on the structural modification of phosphoenolpyruvate
基于磷酸烯醇丙酮酸结构修饰的蛋白质醇磷酸化研究进展
  • 批准号:
    22KJ1152
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Nickel Cross-Coupling Cascades with α-Heteroatom Radicals to Prepare Sterically Hindered Alcohols and Amines
镍与α-杂原子自由基交叉偶联级联制备位阻醇和胺
  • 批准号:
    10604535
  • 财政年份:
    2023
  • 资助金额:
    $ 14.9万
  • 项目类别:
Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines
更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响
  • 批准号:
    571856-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Alliance Grants
Pd-Catalyzed C(sp3)-H Functionalizations Directed by Free Alcohols and Boc-Protected Amines
由游离醇和 Boc 保护的胺引导的 Pd 催化 C(sp3)-H 官能化
  • 批准号:
    10606508
  • 财政年份:
    2022
  • 资助金额:
    $ 14.9万
  • 项目类别:
MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols
MPS-Ascend:镍/光氧化还原催化的 C(sp3)→C(sp3) 烷基卤化物和活化醇之间的交叉偶联
  • 批准号:
    2213210
  • 财政年份:
    2022
  • 资助金额:
    $ 14.9万
  • 项目类别:
    Fellowship Award
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了