Head and Neck squamous cell carcinoma radiation response modulation by HPV
HPV 调节头颈鳞状细胞癌放射反应
基本信息
- 批准号:8628797
- 负责人:
- 金额:$ 24.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-03-01 至 2016-02-28
- 项目状态:已结题
- 来源:
- 关键词:AgeAlcoholsApoptoticAwardBiological ModelsBiologyCell LineCell physiologyCellsClinicalClinical ResearchClinical TrialsComplexConflict (Psychology)DevelopmentDiseaseDown-RegulationEGFR Protein OverexpressionEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorFamily memberFutureGenesGoalsGrantHead and Neck CancerHead and Neck Squamous Cell CarcinomaHumanHuman PapillomavirusHuman papilloma virus infectionIncidenceIonizing radiationJUN geneLeadLearningLinkMalignant Epithelial CellMalignant NeoplasmsMediatingMembrane ProteinsMentorsMolecularMolecular VirologyOutcomePathway interactionsPatientsPhasePlayPrimary NeoplasmPrincipal InvestigatorProtein p53Protein phosphataseProteinsPublic HealthRadiationRadiation ToleranceRadiation-Sensitizing AgentsRadiosensitizationReceptor InhibitionReceptor SignalingReportingResearchRoleScaffolding ProteinSignal PathwayStagingTechniquesTobaccoToxic effectTrainingTransgenic MiceTransgenic ModelTumor Suppressor ProteinsUp-RegulationViral GenesViral ProteinsVirus DiseasesWorkabstractingbasecareer developmentcdc Geneschemoradiationchemotherapyclinical caredesigneffective therapyexperiencegenetic profilingimprovedmembermouse modelnext generationnoveloutcome forecastpatient populationprogramsprotein expressionreceptor expressionresponsetherapy developmenttreatment responsetrial comparingtumortumor xenograftvirology
项目摘要
Project Summary/Abstract
Human papillomavirus (HPV) associated head and neck cancer is a growing public health concern. These
patients commonly present at a younger age and with more advanced stage disease than patients with
traditional tobacco and alcohol associated head and neck squamous cell carcinoma (HNSCC). Paradoxically,
these HPV-associated tumors show notably improved survival outcomes. Mechanisms underlying these
improved outcomes remain unclear. The work proposed in this Pathways to Independence Award has two
primary goals: 1) to facilitate career development of the principal investigator (PI) and to help establish his
independence to lead a research program investigating radiation response in virally associated cancers; and,
2) to understand how HPV-associated HNSCC differs from traditional HNSCC in response to radiation and
chemotherapy. During the mentored phase of research, the PI will obtain additional training in molecular
virology, human papillomavirus biology, and mouse models of cancer. The research conducted during the
mentored phase will examine why HPV-associated HNSCC are more sensitive than traditional HNSCC to
radiation and chemotherapy and to examine the ability of epidermal growth factor receptor (EGFR) inhibitors to
sensitize HPV-associated head and neck cancer to radiation despite low levels of EGFR expression. During
the independent phase, research will examine the impact of HPV viral proteins on EGFR inhibitor-mediated
radiosensitization and the impact of EGFR loss on radiosensitization strategies. These studies will provide new
clues regarding mechanisms of increased sensitivity to radiation and chemotherapy and may identify important
new targets for therapy development to further improve outcome for patients with both HPV-associated and
non-HPV-associated head and neck cancer.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('RANDALL J KIMPLE', 18)}}的其他基金
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Intra-salivary gland autotransplantation of marrow mesenchymal stromal cells for treatment of radiation induced xerostomia
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- 批准号:
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10652384 - 财政年份:2021
- 资助金额:
$ 24.15万 - 项目类别:
Improving the translational value of head and neck cancer patient-in-mouse models
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- 批准号:
10298211 - 财政年份:2021
- 资助金额:
$ 24.15万 - 项目类别:
Head and Neck squamous cell carcinoma radiation response modulation by HPV
HPV 调节头颈鳞状细胞癌放射反应
- 批准号:
8604213 - 财政年份:2013
- 资助金额:
$ 24.15万 - 项目类别:
Head and Neck squamous cell carcinoma radiation response modulation by HPV
HPV 调节头颈鳞状细胞癌放射反应
- 批准号:
8165405 - 财政年份:2011
- 资助金额:
$ 24.15万 - 项目类别:
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