NINDS Stroke Trials Network - Regional Coordinating Center

NINDS 中风试验网络 - 区域协调中心

• 批准号: 10593651
• 负责人: KAMAKSHI LAKSHMINARAYAN
• 金额: $ 30.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10593651
• 关键词: Address; Affect; Age; Award; Caring; Cessation of life; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Development; Disease; Education; Emergency Care; Emergency Medicine; Emergency research; Environment; Fostering; Funding; Goals; Hospitals; Incubators; Individual; Infrastructure; Intervention; Medicine; Minnesota; Mission; Multi-Institutional Clinical Trial; Multicenter Trials; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Patient Recruitments; Patients; Population; Prevention; Public Health; Recovery; Research; Research Personnel; Research Training; Role; Science; Site; Stroke; Stroke prevention; StrokeNet clinical trials; Time; Training; United States National Institutes of Health; Universities; Work; career; career development; design; disability; experience; follow-up; human subject protection; improved; innovation; investigator-initiated trial; medical specialties; member; mortality; nervous system disorder; programs; recruit; research and development; stroke clinical trials; stroke therapy; stroke trials; trend

Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number four cause of none-accidental death in the U.S. It is still the leading cause of major disability, and as the population ages and becomes more diverse, the number of affected individuals is expected to significantly grow. The mission of NINDS is to reduce the burden of neurological disease and stroke. Multicenter clinical trials are key in advancing the science and practice of stroke treatment. National Institutes of Health funded clinical trials have often suffered from long start up time and delays in completing the research. Disease specific research consortiums are part of a national trend to improve these deficiencies by providing a common infrastructure that will facilitate the design, startup, and conduct of multicenter trials, streamlining site selection, research team organization, and human subject protection. It will minimize the need to reorganize the research team for every new trial. Enhanced collaboration will result from such a network, and will function as an incubator for new research and provide a rich environment for research training. The StrokeNET network was created in 2013 to achieve those goals. The University of Minnesota (UMN) and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It has extensive experience in implementing research networks, proven as a current member in StrokeNet, and collaboration with the University of Minnesota hub of SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network, the NINDS/NHLBI emergency medicine research network), as well as the previous experience and relationships built by being part of the two previous funding cycles of the NINDS Neurological Emergency Research Network (NETT). The leaders for this application are experienced in stroke clinical research, managing research networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Within the previous cycle of StrokeNET, our regional center contributed significantly to the network, participating in seven clinical trials with the total number of subjects recruited within the top tier of all RCC’s, a very high rate of patient retention, subject follow-up and document completion. We have actively engaged with 13 hospitals regionally that have recruited patients into network trials. We have brought two proposals for investigator initiated trials and served on several key committees within the network. We have trained four StrokeNet fellows and a team member served on the education committee. Overall, the current stroke program at the University of Minnesota is an excellent candidate to renew its role as an NIH StrokeNet Regional Coordinating Center.

中风是一种常见的神经系统疾病，是一个日益严重的公共卫生问题。虽然死亡率 在美国，它仍然是非意外死亡的第四大原因。 严重残疾，随着人口老龄化和变得更加多样化，受影响的个人数量 预计将大幅增长。NINDS的使命是减轻神经系统疾病的负担， 中风多中心临床试验是推进中风治疗科学和实践的关键。国家 卫生研究院资助的临床试验经常遭受启动时间长和完成延迟的困扰 研究疾病特异性研究联盟是改善这些缺陷的国家趋势的一部分 通过提供一个共同的基础设施，促进多中心试验的设计、启动和实施， 简化研究中心选择、研究团队组织和人类受试者保护。这将最大限度地减少 为每一项新试验重组研究团队这样一个网络将加强合作， 并将作为新研究的孵化器，为研究培训提供丰富的环境。的 StrokeNET网络创建于2013年，以实现这些目标。明尼苏达大学（UMN）及其 中风计划是唯一有资格为区域协调中心服务。它可以获得广泛的 与该领域相关的学术研究人员，在临床研究的各个领域具有深度。具有广泛 在实施研究网络方面的经验，被证明是StrokeNet的现任成员， 与明尼苏达大学SIREN中心（EmeRgENcy护理临床试验创新战略）合作， 网络，NINDS/NHLBI急救医学研究网络），以及以前的经验和 通过参与NINDS神经系统紧急情况前两个资助周期建立的关系 研究网络（NETT）。该应用的领导者在中风临床研究方面经验丰富， 管理研究网络，并且是该主题的专家。需要的各种专业 为成功实施审判而进行的合作已在行政上与合作单位协调一致 超越传统部门。在上一个StrokeNET周期内，我们的区域中心为 重要的是网络，参加了七个临床试验的总人数招募的主题 在所有RCC的顶层中，患者保留率、受试者随访率和记录率非常高 建成我们积极与13家地区医院合作，招募患者加入网络 审判我们为研究者发起的试验提出了两项建议，并在几个关键委员会任职 在网络中。我们已经培训了四名StrokeNet研究员和一名团队成员， 以马克思总的来说，明尼苏达大学目前的中风项目是一个很好的候选项目， 更新其作为NIH StrokeNet区域协调中心的角色。