NINDS Stroke Trials Network - Regional Coordinating Center

中风是一种常见的神经系统疾病，也是一个日益严重的公共卫生问题。尽管死亡率是 在美国，它仍然是非意外死亡的第四大原因。它仍然是 重大残疾，随着人口老龄化和变得更加多样化，受影响的个人数量为 预计将大幅增长。NINDS的使命是减轻神经系统疾病的负担和 卒中。多中心临床试验是推进中风治疗的科学和实践的关键。全国 卫生研究院资助的临床试验往往存在启动时间长和完成延迟的问题 这项研究。疾病特异性研究联盟是改善这些缺陷的国家趋势的一部分 通过提供可促进多中心试验的设计、启动和实施的通用基础设施， 精简选址、研究团队组织和人类主体保护。它将最大限度地减少对 为每一项新的试验重组研究团队。这样的网络将带来增强的协作， 并将作为新研究的孵化器，为研究培训提供丰富的环境。这个 StrokeNET网络成立于2013年，就是为了实现这些目标。明尼苏达大学及其 中风计划是唯一有资格为区域协调中心服务的项目。它可以访问一系列广泛的 与这一领域相关的学术研究人员，在临床研究的各个领域具有深度。它有广泛的 实施研究网络的经验，已被证明是StrokeNet的当前成员，并进行协作 与明尼苏达大学SIREN中心(创新紧急护理临床试验的战略)合作 NINDS/NHLBI急救医学研究网络)，以及以前的经验和 作为NINDS神经急诊前两个资金周期的一部分建立的关系 研究网络(NETT)。这项应用的领导者在中风临床研究方面经验丰富， 管理研究网络，是该主题的专家。所需的各种专业 为成功实施试验而进行的协作已经在协作单位中进行了行政协调 超越传统部门。在StrokeNET的前一个周期内，我们的区域中心做出了贡献 对网络意义重大，参与了七项临床试验，招募的受试者总数 在所有RCC的顶层中，患者保留率、受试者随访和文档记录的比率非常高 完成了。我们积极与13家地区已招募病人入网的医院接洽。 审判。我们提出了两项建议，由调查员发起试验，并在几个关键委员会任职 在网络中。我们已经培训了四名StrokeNet研究员和一名团队成员 委员会审议阶段。总体而言，明尼苏达大学目前的中风项目是一个很好的候选者 更新其作为NIH StrokeNet区域协调中心的角色。

Stroke is a common neurological disease and is a growing major public health problem. Although mortality is declining, it remains the number four cause of none-accidental death in the U.S. It is still the leading cause of major disability, and as the population ages and becomes more diverse, the number of affected individuals is expected to significantly grow. The mission of NINDS is to reduce the burden of neurological disease and stroke. Multicenter clinical trials are key in advancing the science and practice of stroke treatment. National Institutes of Health funded clinical trials have often suffered from long start up time and delays in completing the research. Disease specific research consortiums are part of a national trend to improve these deficiencies by providing a common infrastructure that will facilitate the design, startup, and conduct of multicenter trials, streamlining site selection, research team organization, and human subject protection. It will minimize the need to reorganize the research team for every new trial. Enhanced collaboration will result from such a network, and will function as an incubator for new research and provide a rich environment for research training. The StrokeNET network was created in 2013 to achieve those goals. The University of Minnesota (UMN) and its stroke program are uniquely qualified to serve a Regional Coordinating Center. It has access to a broad set of academic researchers relevant for this field, with depth in various domains of clinical research. It has extensive experience in implementing research networks, proven as a current member in StrokeNet, and collaboration with the University of Minnesota hub of SIREN (Strategies to Innovate EmeRgENcy Care Clinical Trials Network, the NINDS/NHLBI emergency medicine research network), as well as the previous experience and relationships built by being part of the two previous funding cycles of the NINDS Neurological Emergency Research Network (NETT). The leaders for this application are experienced in stroke clinical research, managing research networks, and are experts in the subject matter. The various specialties needed to collaborate for successful implementation of the trials are already aligned administratively in collaborative units beyond traditional departments. Within the previous cycle of StrokeNET, our regional center contributed significantly to the network, participating in seven clinical trials with the total number of subjects recruited within the top tier of all RCC’s, a very high rate of patient retention, subject follow-up and document completion. We have actively engaged with 13 hospitals regionally that have recruited patients into network trials. We have brought two proposals for investigator initiated trials and served on several key committees within the network. We have trained four StrokeNet fellows and a team member served on the education committee. Overall, the current stroke program at the University of Minnesota is an excellent candidate to renew its role as an NIH StrokeNet Regional Coordinating Center.