Stimulating Access to Research in Residency (StARR) - NHLBI

促进住院医师研究的机会 (StARR) - NHLBI

• 批准号: 10597856
• 负责人: Mai ElMallah
• 金额: $ 31.48万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597856
• 关键词: Achievement; Address; Affect; Applications Grants; Area; Award; Basic Science; Biomedical Research; Blood; Blood Vessels; Board Certification; Cardiopulmonary; Cardiovascular system; Caring; Clinic; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Country; Critiques; Data Science; Dedications; Development; Development Plans; Diagnosis; Disease; Disparity; Drug Kinetics; Education; Educational workshop; Eligibility Determination; Ensure; Evaluation; Extramural Activities; Faculty; Fellowship; Fostering; Foundations; Funding; Goals; Grant; Health; Healthcare; Heart; Heart Diseases; Hematological Disease; Human; Individual; Infrastructure; Institution; Journals; Laboratory Research; Life Cycle Stages; Lung; Lung diseases; Manuscripts; Medical; Medicine; Mentors; Mentorship; Methods; Mission; Modality; Modernization; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; Operative Surgical Procedures; Outcome; Pathway interactions; Pediatrics; Peer Review; Phase; Physicians; Physicians' Offices; Positioning Attribute; Productivity; Public Health; Request for Applications; Research; Research Personnel; Research Priority; Research Project Grants; Research Training; Residencies; Resources; Scholarship; Scientist; Signal Transduction; Societies; Structure; Study Section; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career; career development; clinical training; clinical translation; coronavirus disease; disorder prevention; early phase clinical trial; experience; health data; implementation research; improved; innovation; medical schools; meetings; multidisciplinary; next generation; novel diagnostics; novel strategies; novel therapeutic intervention; pediatric department; preference; prevent; programs; public health relevance; response; skills; success; tool

ABSTRACT / PROJECT SUMMARY In response to a 30-year decline in the number of physician-scientists, attributed to prolonged clinical training, doubling or tripling of education debt, uncertain grant funding prospects, unclear career trajectories, and a lack of mentored research opportunities during early clinical training, the NIH started the Mentored ResearchPathway in Residency R38 program. Residency training, a critical step in physician training, is often carried out by training programs that do not support physician-scientist development. Significant gaps exist for protected research time, structured trainingand mentoring, and support to continue researchafter returningto the clinic. The primary goal of the multidisciplinary Duke NHLBI Scientist-Clinician-Investigator Stimulating access to Research during Residency (Duke SCI-StARR) program is to train a diverse cadre of physician-scientists who will lead the development, implementation, and evaluation of new clinical modalities to prevent, diagnose, and treat disease states affecting the heart, lungs, and blood throughout the life-course. Duke NHLBI SCI-StARR trainS residents across 3 departments: Pediatrics, Medicine, and Surgery in areas along the full biomedical research continuum (basic/translational, early phase clinical trials and pharmacokinetics, and late phase clinical trials and outcomes) with a theme of improving health over the life course. The program will consist of four training aims: 1) comprehensive didactics covering basic, translational, and clinical research and professional development; 2) development and completion of a research project and an individualized career development plan; 3) establishment of a track record of scholarly activity; and 4) eligibility for board certification and continuation to subspecialty training. Duke NHLBI SCI-StARR will be led by an Executive Committee (EC) of MPIs Mai K. ElMallah, MD (Pediatrics), Scott Palmer, MD, MHS (Medicine), and David Harpole, Jr., MD (Surgery), and an Expanded EC of Residency Program Directors and Program Coordinators, capitalizing on a team of 33 multi-departmental, multi-disciplinary, well-funded, and experienced faculty preceptors. This application requests support for three Resident-Investigators each year with each trainee to be supported for 18- 24 months of research. Upon completion of the program, these individuals will be capable of transitioning to research-intense fellowship training, successfully competing for extramural funding to support a path to independence as physician-scientists, and becoming the next generation of physicians leading and mentoring trainees in clinically-oriented research of disease states affecting the heart, lungs, and blood. Achievement of the program's objectives will fulfill urgent medical needs for: 1) more full-time academic physician-researchers and mentors in medical schools throughout the country and 2) innovations and clinical translation of novel strategies to improve the health of individuals across the life course.

摘要/项目总结 由于长期的临床训练，30年来医生科学家的数量下降， 教育债务增加一倍或两倍，赠款资金前景不确定，职业轨迹不明确，缺乏 在早期临床培训期间，NIH提供了大量的指导研究机会， 在R38居住计划中。住院医师培训是医师培训的重要环节， 不支持医生-科学家发展的项目。受保护的研究存在重大差距 时间，结构化的培训和指导，并支持返回诊所后继续研究。主 多学科杜克NHLBI科学家-临床医生-研究者的目标是在研究期间刺激研究访问 住院医师（杜克SCI-StARR）计划旨在培养一批多样化的医生科学家，他们将领导 开发、实施和评估预防、诊断和治疗疾病的新临床模式 影响整个生命过程中的心脏、肺和血液的状态。杜克NHLBI SCI-StARR列车居民 跨3个部门：儿科，内科和外科，沿着整个生物医学研究领域 连续体（基础/转化、早期临床试验和药代动力学以及晚期临床试验） 试验和结果），主题是改善生命过程中的健康。该计划将包括四个 培养目标：1）综合教学法，涵盖基础，转化和临床研究和专业 发展; 2）开发和完成研究项目和个性化的职业发展 计划; 3）建立学术活动的跟踪记录; 4）获得董事会认证的资格， 继续进行专科培训。杜克NHLBI SCI-StARR将由执行委员会（EC）领导， MPIs Mai K. ElMallah，医学博士（儿科），Scott Palmer，医学博士，MHS（医学）和大卫哈波尔，Jr.，MD （外科），以及住院医师计划主任和计划协调员的扩大EC，利用 团队33多部门，多学科，资金充足，经验丰富的教师导师。这 应用程序要求每年支持三名驻地调查员，每名受训人员支持18- 24个月的研究。在该计划完成后，这些人将能够过渡到 研究密集的奖学金培训，成功地竞争校外资金，以支持一条道路， 作为医生-科学家的独立性，并成为下一代医生的领导和指导 在临床导向的疾病状态影响心脏，肺和血液的研究实习生。实现 该计划的目标将满足以下迫切的医疗需求：1）更多的全职学术医生-研究人员 2）创新和临床翻译的小说 战略，以改善整个生命过程中的个人健康。

项目成果

Amino Acid-Level Signal-to-Noise Analysis Aids in Pathogenicity Prediction of Incidentally Identified TTN-Encoded Titin Truncating Variants.

• DOI: 10.1161/circgen.120.003131
• 发表时间: 2021-03
• 期刊: Circulation. Genomic and precision medicine
• 作者: Connell PS;Berkman AM;Souder BM;Pirozzi EJ;Lovin JJ;Rosenfeld JA;Liu P;Tunuguntla H;Allen HD;Denfield SW;Kim JJ;Landstrom AP
• 通讯作者: Landstrom AP

The genetic underpinnings of anthracycline-induced cardiomyopathy predisposition.

• DOI: 10.1111/cge.13968
• 发表时间: 2021-08
• 期刊: Clinical genetics
• 影响因子: 3.5

Permissive Hypertension and Collateral Revascularization May Allow Avoidance of Cerebrospinal Fluid Drainage in Thoracic Endovascular Aortic Repair.

• DOI: 10.1016/j.athoracsur.2020.04.101
• 发表时间: 2020-11
• 期刊: The Annals of thoracic surgery
• 作者: Weissler EH;Voigt SL;Raman V;Jawitz O;Doberne J;Anand J;Plichta R;Gaca JG;McCann RL;Hughes GC
• 通讯作者: Hughes GC

Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.

• DOI: 10.1007/s11886-020-01422-x
• 发表时间: 2020-10-10
• 期刊: Current cardiology reports
• 影响因子: 3.7
• 作者: Regan JA;Shah SH
• 通讯作者: Shah SH

Painful, reappearing eruption in a medically complex 4-year-old.

一名病情复杂的 4 岁儿童再次出现疼痛性皮疹。

• DOI: 10.1136/bcr-2020-239310
• 发表时间: 2021
• 期刊: BMJ case reports
• 影响因子: 0.9
• 作者: Sooy,Meredith;Randell,RachelL;Tchapyjnikov,Dmitry;Werner,Klaus;Nazareth-Pidgeon,Kristina
• 通讯作者: Nazareth-Pidgeon,Kristina