Johns Hopkins University Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

约翰·霍普金斯大学站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10599562
• 负责人: ALLISON L AGWU
• 金额: $ 31.62万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599562
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; Advocate; Age; Age-Years; Americas; Baltimore; Black race; Caring; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communicable Diseases; Communities; Community Networks; Continuity of Patient Care; Data Collection; Development; Disease Progression; Drug Kinetics; Ensure; Epidemic; Failure; Funding; Goals; Government; HIV; HIV Infections; HIV diagnosis; Hispanic; Home; Industry; Infrastructure; Institution; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Intervention Studies; Investigational Drugs; Latinx; Lead; Maryland; Outcome; Outcomes Research; Persons; Policies; Policy Maker; Population; Prevention; Public Health; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Risk; Science; Site; Social Behavior; State Government; Testing; Time; Translational Research; Underrepresented Populations; United States; Universities; Vaccines; Viral; Voice; Youth; adolescent health outcomes; antiretroviral therapy; base; clinical care; cohort; community center; disease transmission; disorder risk; experience; implementation outcomes; improved; innovation; lens; member; multidisciplinary; novel; operation; programs; protocol development; recruit; retention rate; success; synergism; virtual; young adult

ABSTRACT Johns Hopkins University Youth (ages 13-24) living with HIV comprise one fourth of new HIV diagnoses in the United States (U.S.) and have the lowest rates of engagement and retention in care and prevention, initiation of antiretroviral treatment, and virologic suppression, increasing the risk of disease progression and transmission, with important public health implications. These disparities threaten the U.S. government's target of ending new HIV infections by 2030, outlined in the Ending the Epidemic Plan for America (EHE). The Adolescent Trials' Network (ATN), the only youth-targeted HIV network, combines expertise in clinical care and research to develop optimal approaches to addressing the challenges facing youth at-risk for and living with HIV. Located in Baltimore, Maryland, an EHE jurisdiction, the Johns Hopkins Adolescent Young Adult Research Equity for Adolescent Care and HIV Consortium (JHU AYA REACH) has a long-standing overarching commitment to mitigate the impact of HIV and improve health outcomes for AYA at-risk and/or living with HIV via a clinical research program focused on integrated, cross-disciplinary studies of AYA-centered novel interventions (e.g., biomedical, management, strategy) that span from bedside to community. Synergies between clinical care research, public health, and community, centered on AYA, substantially enhances relevance, improves feasibility, optimizes success, and amplifies impact. The JHU AYA REACH infrastructure aims to optimize these synergies ultimately uniting the scientific rigor (clinical trial design and implementation, outcomes, interventions) with clinical expertise and real-world understanding, ensuring that research questions/answers are relevant, implementable, and scalable. Led by Drs. Agwu and Sanders (Co-Project Leads), the JHU AYA REACH, has a longstanding and productive involvement in clinical trials' networks and cohorts (ATN, International Maternal Pediatric Adolescent AIDS Clinical Trials' Group [IMPAACT]) with much of that involvement overseen by Westat and JHU AYA REACH is home to a prolific group of diverse, collaborative multidisciplinary investigators. The consortium includes an established network of community and governmental partners increasing the likelihood of effective translation of the research outcomes. For this application, we will: (1) Develop and conduct science that incorporates innovative approaches to addressing the critical scientific gaps and questions impacting AYAs, particularly Black and Hispanic/LatinX AYA, at-risk for or living with HIV; (2) Coordinate with diverse entities, affiliates, and stakeholders across the institution and community, including AYAs, to ensure timely, accurate, and effective engagement in the proposed research; and (3) En sure that AYA voices and lived experiences are central to the research activities of the JHU AYA REACH through active and purposeful involvement of AYA through the Youth Advisory Board (YAB) and other forums. The JHU AYA REACH's expertise, experience, and goals directly align with the ATN enriching the capacity to develop and conduct innovative and impactful interdisciplinary AYA-specific research, providing added overall value to the proposed ATN.

约翰·霍普金斯大学摘要 青少年(13-24岁)艾滋病毒携带者占美国新增艾滋病毒诊断病例的四分之一。和 在护理和预防、开始抗逆转录病毒治疗方面参与率和保留率最低， 和病毒学抑制，增加疾病进展和传播的风险，与重要的公众 对健康的影响。这些差距威胁到美国政府结束新的艾滋病毒感染的目标 2030年，在《结束美国流行病计划》(EHE)中概述。青少年试验网络(ATN)， 唯一以青年为目标的艾滋病毒网络，结合临床护理和研究方面的专业知识，开发最佳 应对艾滋病毒高危青年和艾滋病毒携带者面临的挑战的方法。位于巴尔的摩， 马里兰州，EHE辖区，约翰·霍普金斯青少年青少年研究基金 CARE和HIV联盟(JHU Aya REACH)长期致力于减轻 通过临床研究影响艾滋病毒并改善高危人群和/或艾滋病毒携带者的健康结局 该计划侧重于对以AYA为中心的新干预措施的综合、跨学科研究(例如， 生物医学、管理、战略)，从床边到社区。临床护理之间的协同作用 研究、公共卫生和社区，以Aya为中心，大大增强了相关性，改善了 可行，优化成功，扩大影响。JHU Aya REACH基础设施旨在优化 这些协同效应最终统一了科学的严谨性(临床试验设计和实施、结果、 干预)具有临床专业知识和对现实世界的了解，确保研究问题/答案 具有相关性、可实施性和可伸缩性。由阿格武博士和桑德斯博士(联合项目负责人)领导的JHU Aya REACH，长期有效地参与临床试验网络和队列(ATN， 国际母儿青少年艾滋病临床试验小组[IMPAACT]) 由Westat和JHU Aya Reach监督的参与是一个多样化、协作性多产的团体的所在地 多学科调查员。该联盟包括一个已建立的社区网络和 政府合作伙伴增加了有效转化研究成果的可能性。为了这个 应用，我们将：(1)开发和开展包含创新方法的科学，以解决 影响AYA的关键科学差距和问题，特别是处于风险中的黑人和西班牙裔/拉丁裔AYA (2)与机构内不同的实体、附属机构和利益相关者进行协调，并 社区，包括AYA，确保及时、准确和有效地参与拟议的研究； 和(3)EN 当然，阿雅的声音和生活经历是JHU阿雅研究活动的核心 通过青年咨询委员会(YAB)和其他机构积极和有目的地参与AYA 论坛。JHU Aya REACH的专业知识、经验和目标直接与ATN保持一致，从而丰富了 有能力开发和开展创新的、有影响力的跨学科研究，提供 为拟议的ATN增加了整体价值。