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Anti-hIAPP for the preservation of pancreatic function in Type 2 Diabetes

抗 hIAPP 用于保护 2 型糖尿病患者的胰腺功能

基本信息

批准号：
10600613
负责人：
Joana M Murad
金额：
$ 29.99万
依托单位：
CELDARA MEDICAL, LLC
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-22 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10600613
关键词：
Address Affect Affinity American Amyloid Amyloid Fibrils Amyloidosis Animal Model Antigens Apoptosis Beta Cell Binding Binding Proteins Blood Glucose Cell Death Cell Survival Cell physiology Cells Dependence Deposition Development Diabetes Mellitus Disease Disease Progression Dose Drug Kinetics Engineering Epidemic Evaluation Excision Future Gastroparesis Glucagon Glucose Guidelines Health Hormones Human In Vitro Individual Industry Standard Insulin Insulin Resistance Islets of Langerhans Lead Medical Membrane Molecular Chaperones Molecular Conformation Monoclonal Antibodies Mus Non-Insulin-Dependent Diabetes Mellitus Pancreas Pathologic Pathology Patients Peptides Peripheral Pharmaceutical Preparations Phase Physicians Physiological Population Pramlintide Pre-Clinical Model Prediabetes syndrome Process Production Public Health Rodent Satiation Schedule Scientist Specificity Stress Structure Therapeutic Therapeutic Monoclonal Antibodies Therapeutic Uses Time Toxic effect Transgenes Transgenic Mice Treatment Efficacy United States amyloid formation analog analytical method biophysical properties cell bank cell injury cost diabetic diabetic patient efficacy study glycemic control high risk improved in vivo insulin secretion islet islet amyloid polypeptide manufacturability meetings mouse model novel novel therapeutic intervention novel therapeutics nucleobindin pancreatic juice peptide hormone peripheral blood preclinical development preservation prevent response stable cell line standard of care success therapeutic development tool

项目摘要

Project Summary According to the American Diabetes Association, Type 2 diabetes mellitus (T2D) affects at least 30 million Americans and is a major unmet public health concern with an annual cost in the United States of over $300 billion dollars. Additionally, nearly 25% of the U.S. population is already considered prediabetic, or at high risk of developing T2D. These individuals are characterized by poor glycemic control as a result of insulin resistance combined with reduced insulin secretion in response to glucose stimulation. At the prediabetic or early diabetic stages, insulin insufficiency is frequently managed by medications that stimulate pancreatic secretion, which is accompanied by increased levels of human islet amyloid polypeptide, hIAPP (amylin). Native hIAPP in its monomeric form is a hormone that inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent. However, when hIAPP misfolds, which is common at elevated production, it results in structures called protofibrils. These protofibrils are soluble, highly toxic, and capable of inducing cell death. The stimulated co- secretion of hIAPP with insulin leads to a pathologic cycle of increased hIAPP, including misfolded hIAPP, that leads to β cell toxicity in prediabetics and diabetics. The ensuing deficits in β cell function drive an increased need for insulin secretion, which is accompanied by further hIAPP secretion. In this sense, T2D is an amyloid- induced disease as evidenced by the presence of hIAPP plaque deposits in the pancreata of more than 90% of T2D patients. Developing new therapeutic strategies that target toxic hIAPP protofibrils, inhibit their deposition as toxic amylin fibrils, and ultimately preserve β cell health is a priority for addressing this major unmet need in T2D. Current standard-of-care in T2D is able to provide some control of blood glucose levels, but it fails to address the  cell decline and its contribution to T2D progression. In this application we propose to advance a novel therapeutic platform and our lead product from that platform, CM-TS1. CM-TS1 is a monoclonal antibody that specifically targets protofibrils, soluble conformations of hIAPP for rapid clearance prior to plaque deposition and  cell destruction. We have already demonstrated that CM-TS1 is capable of binding to these soluble protofibrils in peripheral blood and in the pancreata of a T2D murine model. We will continue therapeutic development by first validating our initial finding by demonstrating that CM-TS1 can clear hIAPP in an industry standard preclinical model leading to a reduction of T2D pathology. Following this in vivo proof-of-concept, we will then advance CM- TS1 through humanization and into early preclinical development including manufacturability, stable cell line construction, and non-GLP pharmacokinetic and toxicity studies ultimately culminating in a pre-IND Type B meeting with the FDA. The milestone of ultimate success will be launching this promising product into future IND-enabling studies in order to successfully reach the patients that need it the most.

项目总结