A Functional Investigation of Structural Variants Associated with Schizophrenia

工程 这个 使用 使用 结构 已获得 窝藏 评估 临床 至 诊断学 《医学》 目标 摘要 目前的项目名为“相关结构变体的功能研究” 精神分裂症“提出了对一类与精神分裂症相关的基因组变异的研究 精神分裂症风险，“结构性变异”，使用两种方法。首先，它的作用是 变异将在大脑水平上进行研究，在死后的大脑样本中 来自精神分裂症患者和正常健康对照组。第二，病人 将招募特定的结构变体进行临床评估，包括 行为和认知。这项研究将考虑到神经生物学和 一类可能有贡献的重要基因组变异的特征 精神分裂症的风险。拟议中的调查有可能导致改进 精神分裂症的发病率，以及通过精确度提高的治疗方案 根据潜在的遗传变异对患者进行分层的方法，以更有效地 现有的和新的治疗方法。

PROJECT The with with structural obtained harboring assessment clinical to diagnosis medicine' target SUMMARY current project titled “ A Functional Investigation of Structural Variants Associated Schizophrenia ” proposes the investigation of a class of genomic variants associated schizophrenia risk, `structural variants', using two approaches. First, t he function of variants will be investigated at the level of the brain, in post-mortem brain samples from patients with schizophrenia and normal healthy controls. Second, patients specific structural variants will be recruited for clinical evaluation, including an of behavior and cognition. This study will allow for the neurobiological and characterization of an important class of genomic variants that may be contributory schizophrenia risk. The proposed investigation has the potential to lead to improved of schizophrenia, as well as improved treatment options, through a `precision approach of stratifying patients by underlying genetic variants, to more effectively existing and novel therapeutics.