Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults (MESA As)

项目总结 这项名为《多民族成年人的低水平砷暴露与心血管疾病》的父母赠款 (MESA AS)，旨在调查低水平砷(As)暴露对美国成年人心血管的影响 多个种族/民族群体。动脉粥样硬化的多种族研究(MESA)是一项基于人群的研究 来自美国6个城市的近7000名参与者，20年来健康状况已知。在.期间 在父母赠款中，我们注意到我们可以确定硒(Se)的存在。 在我们作为物种进行测量的同一分析运行中。在P30试点研究的支持下， 我们正在梅萨尿样的一个子集中验证这些物种。我们建议扩大这项试点，并 父母赠款的范围，以评估与低水平硒暴露相关的程度 心血管疾病，通过在父母拨款中增加关于尿中硒物种的新数据。硒是一种 必需元素的安全范围很窄，这意味着低和高摄入量都会增加疾病风险。 人类主要通过尿液排泄硒，人们对尿硒的形态特别感兴趣。 人类生物新陈代谢和与硒相关的健康结果。人类尿硒的形态可能会受到 膳食硒摄入量和遗传变异性，主要由硒、三甲基硒离子和 无机Se氧阴离子。然而，硒物种对人类健康和疾病的个体影响仍然存在。 这在很大程度上是未知的，因为流行病学研究很少测量尿中的硒物种。我们计划 加强我们目前在MESA的分析方法，最初是为尿中As的形态建立的，用于 一次测量同时测定砷和硒的形态。我国土壤中硒形态的有效性 尿液将为检验个体硒物种和基因-硒物种之间的联系提供关键数据。 相互作用，而不仅仅是全硒对人类健康结果的影响。

PROJECT SUMMARY The parent grant, entitled “Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults (MESA As)”, aims to investigate the cardiovascular effects of low-level arsenic (As) exposure in US adults of multiple racial/ethnic groups. The Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of nearly 7,000 participants from 6 US cities, with known health outcomes over two decades. During the measurement of urinary As species in the parent grant, we noticed that we could identify selenium (Se) species during the same analytical run in which we measured As species. With support from a P30 pilot study, we are validating those species in a subset of MESA urine samples. We propose to expand this pilot, and the scope of the parent grant, to assess the extent to which low-level Se exposure is associated with cardiovascular disease, by adding new data on Se species in urine to the parent grant. Selenium is an essential element with a narrow safety range, meaning that both low and high intake can increase disease risk. Humans mainly excrete Se through urine and urinary Se speciation is of particular interest for understanding human bio-metabolism and Se-related health outcomes. Human urinary Se speciation can be influenced by dietary Se intake and genetic variability and is dominated by selenosugars, trimethylselenonium ion, and inorganic Se oxyanions. However, the individual influence of Se species on human health and disease remains largely unexplored as it is rare for epidemiological studies to measure Se species in the urine. We plan to augment our current analytical method in MESA, originally established for speciation of As in urine, for the simultaneous determination of As and Se species in a single measurement. The availability of Se species in urine will provide key data to examine the association of individual Se species and gene-Se species interactions, rather than total Se only, on human health outcomes.