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Columbia University and Northern Plains Partnership for the Superfund Research Program

哥伦比亚大学和北部平原超级基金研究计划合作伙伴关系

基本信息

批准号：
10354268
负责人：
Ana Navas-Acien
金额：
$ 209.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10354268
关键词：
Address Adsorption Adult Affect Area Arizona Arsenic Biological Cardiometabolic Disease Cardiovascular Diseases Chemistry Cheyenne Childhood Collaborations Communities Community Outreach Conceptions Congresses Data Data Analyses Diabetes Mellitus Dietary Intervention Distal Elements Ensure Epidemic Epidemiology Etiology Excision Exposure to Fractionation Government Hazardous Waste Sites Health Heart Heart Diseases Household Human Indigenous Intervention Isotopes Joints Knowledge Laboratories Life Light Longitudinal Studies Maintenance Measurement Measures Metal exposure Metals Modeling Molecular Molecular Profiling Monitor Mus Native Americans New Mexico Nutritional status Oxidation-Reduction Pathway interactions Play Policies Population Prevention Privatization Program Research Project Grants Research Research Activity Research Design Research Ethics Resolution Risk Reduction Rivers Role Rural Rural Community Sampling Science Scientist Signal Recognition Particle Sioux Indians Source South Dakota Specimen Superfund System Techniques Technology Time Tissue Sample Tissues Toxic effect Training Translational Research Treatment Failure Tribes United States Indian Health Service Universities Uranium Urine Water base cardiometabolism citizen science community engagement complex data contaminated drinking water data management disorder prevention drinking water early life exposure effective intervention epigenomics evidence base experience ground water hazardous drinking innovation innovative technologies metabolomics mouse model multiple omics next generation northern Native American northern plains novel photosynthetic bacteria programs remediation stable isotope success superfund site toxic metal transcriptomics tribal community tribal lands urinary wasting water quality water sampling well water

项目摘要

Summary Tribal lands are impacted by more than 15,000 hazardous waste sites and 7,000 abandoned mines that can disrupt the redox chemistry of aquifers and release toxic metals. In collaboration with tribal communities from North/South Dakota, we found that arsenic (As) and uranium (U) affect drinking water in private wells and rural water systems in the Northern Plains. Our data also show that in the 1990s/early 2000s Native Americans from the Northern Plains experienced urinary As and U levels 2.5 to 5 times higher than other US populations, likely contributing to a high burden of cardiovascular disease. Knowledge is needed on current metal exposure levels, sources (local and distal), health effects (concurrent, latent, joint), mechanistic pathways, and effective remediation systems. To address these scientific and technology gaps, we have established the Columbia University Northern Plains Superfund Research Program. This new partnership has five Projects and four Cores and will use systems science, local knowledge, and innovative technology through the following aims: (1) Develop household-level spatial and temporal models of groundwater metal concentrations integrating new measures of water As, U, and redox parameters with USGS and IHS data. These models can identify safe water vs. where mitigation interventions are needed. (2) Trace sources and cycling of metals in water and biological specimens through stable isotope measurements (U, Se) to reveal redox state and inform on local and distal sources of contamination, directly addressing our communities’ concern. (3) Determine latent and concurrent cardiometabolic effects of As and U in humans (Strong Heart As/U Lifelong study, SHAUL), and in human- relevant mouse models. These data will enhance the assessment of causality and the role of early life exposures. (4) Integrate molecular mechanisms of As and U toxicity using multi-omics (epigenomics, metabolomics) in longitudinal studies in humans (SHAUL) and mice. The cross-species comparison can identify robust signatures and mechanisms to help generate intervention strategies. (5) Develop sustainable interventions using light- based, point-of-use water remediation technology for As/U. This system will produce and recycle adsorption media with photosynthetic bacteria and alert residents before treatment failure. The Community Engagement Core will be centrally located in the Northern Plains, contributing to all research activities and local dissemination. The Data Management and Analysis and Administrative Cores will optimize use of the complex data generated while respecting tribal data sovereignty and promoting evidence-based policies and practices to address hazardous toxic metals and contribute to disease prevention. We will train the next generation of scientists in systems science, technology, Indigenous research ethics, and community outreach. The breadth, depth, and innovation of our approaches, the community’s central role, the institutional support, and our experience working together will lay the groundwork for interventions that address key concerns for water quality and human health in communities in the Northern Plains and near abandoned mines and Superfund sites.

总结