Neonatal predictors of contextualized emotion processing and risk for anxiety

情境化情绪处理和焦虑风险的新生儿预测因素

• 批准号: 10600450
• 负责人: Maria Catalina Camacho
• 金额: $ 6.87万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600450
• 关键词: Age; Anxiety; Anxiety Disorders; Attention; Behavior assessment; Birth; Brain; Chad; Child; Chronic; Complex; Coupled; Cues; Data; Detection; Development; Disease; Early Intervention; Emotional; Emotions; Etiology; Familiarity; Functional Magnetic Resonance Imaging; Functional disorder; Grant; Image; Individual Differences; Infant; Link; Longitudinal Studies; Measures; Mental Depression; Mental Health; Mental disorders; Methods; Mothers; Neonatal; Newborn Infant; Process; Public Health; Regulation; Risk; Sampling; Sleep; Stimulus; Symptoms; Temperament; Testing; Training; Variant; Work; Writing; Youth; auditory stimulus; behavioral response; design; developmental neurobiology; emotional experience; emotional stimulus; high risk; infancy; infant temperament; insight; maternal anxiety; neonatal brain; neonate; neural; neurodevelopment; novel; parent grant; response; skills; training opportunity; visual tracking

PROJECT SUMMARY Depression and anxiety are associated with overlapping dysfunctions in emotion processing, but the etiology is not well understood. Individual differences during infancy in negative temperament—a global measure of a child’s emotional reactivity and regulation tendencies—are associated with increased risk for depression and anxiety. Thus, the emotional dysfunction linked to depression and anxiety appears to begin during early infancy, yet the associated developmental neurobiology is poorly understood. A central barrier to unlocking the developmental neurobiology of emotion dysfunction is we do not know how variation in brain function at birth relates to emotion processing later in infancy, and whether this relation depends on infant temperament. Contextualized emotion processing—processing emotions in the real-world, with competing stimuli and full narrative context—is complex and includes: 1) detection of and attention towards salient stimuli; 2) interpretation and contextualization of this information; and 3) making a behavioral response. Depression and anxiety have been associated with dysfunctions at all three stages, and emerging evidence suggesting that some of these dysfunctions are present at birth. Recent work has found that the variation in newborn brain activation during saliency processing—the first stage of emotion processing—is associated with risk for anxiety. While this links early variation in saliency processing to risk trajectories for anxiety and depression, the developmental sequence is unknown. This study is therefore designed to identify how neonatal brain function is associated with contextualized emotion processing during infancy. This project will add an additional measure to the ongoing Neonatal Predictors of Anxiety Disorders Study (N-PAD; R01MH122389 PI: Sylvester, sponsor), a longitudinal study of mothers and infants. This current grant will substantially increase the impact of the parent grant by adding a video-watching eye-tracking task to the 24-month assessment, allowing us to measure attention to contextualized emotional stimuli. Our central hypothesis is that neonatal activation to salient stimuli (measured with fMRI) predicts attention to contextualized emotional stimuli during infancy (measured with eye tracking), and this relation is strengthened in infants with negative temperaments. Results will provide important insights to how internalizing symptoms emerge across early development. Through this project, the candidate will develop critical expertise in infant neural and behavioral assessments.

项目总结 抑郁和焦虑与情绪处理的重叠功能障碍有关，但其病因是 不是很清楚。婴儿期负性气质的个体差异--一项衡量 儿童的情绪反应和调节倾向--与患抑郁症和 焦虑。因此，与抑郁和焦虑有关的情绪障碍似乎始于早期 婴儿期，然而相关的发育神经生物学却知之甚少。解锁的一个中心障碍 情绪障碍的发育神经生物学是我们不知道大脑功能在出生时如何变异的 与婴儿后期的情绪处理有关，以及这种关系是否取决于婴儿的气质。 情境化情绪处理-在真实世界中处理情绪，具有相互竞争的刺激和完整的 叙事语境--很复杂，包括：1)对显著刺激的检测和注意；2) 对这一信息的解释和语境化；以及3)做出行为反应。抑郁和抑郁 焦虑在所有三个阶段都与功能障碍有关，而且越来越多的证据表明 其中一些功能障碍在出生时就存在。最近的研究发现，新生儿大脑中的变异 情绪加工的第一个阶段--显著加工过程中的激活--与 焦虑。虽然这将显著加工的早期变化与焦虑和抑郁的风险轨迹联系在一起，但 发育顺序尚不清楚。因此，这项研究旨在确定新生儿的大脑功能 与婴儿期的情境化情绪处理有关。该项目将增加一个额外的 正在进行的焦虑症新生儿预测因素研究的测量(N-PAD；R01MH122389 PI：Sylvester， 赞助商)，一项对母亲和婴儿的纵向研究。目前的这笔赠款将大大增加 家长在24个月的评估中增加了一项视频观看眼球跟踪任务，允许我们 测量对情境化情绪刺激的注意力。我们的中心假设是新生儿激活到 显著刺激(用fMRI测量)预测在 婴儿期(用眼球跟踪测量)，这种关系在阴性婴儿中得到加强 性情。研究结果将为内在化症状如何在早期出现提供重要的见解 发展。通过这个项目，候选人将发展婴儿神经和行为方面的关键专业知识 评估。