PILOT STUDY OF ARTIFICIAL GRAVITY AS A MULTI-SYSTEM COUNTERMEASURE TO BED REST

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项研究的目的是测试如何在长时间的太空飞行中，利用旋转航天器产生的力来代替重力。在这项研究中，人造重力？将通过在人体离心机上旋转受试者来创建，太空飞行将通过长时间卧床休息来模拟。卧床休息，头部略低于脚是一个很好的方法，研究人员模仿发生在一个人的身体变化，而在太空旅行时，没有重力。在这项研究中，受试者将被限制在21天的24小时卧床休息，头部略微向下倾斜，以体验宇航员身体在21天失重太空飞行中所经历的一些变化。在这21天内，受试者将不会起床;但是，每天一次，他们将在轮床上被推到离心机设施。在那里，治疗受试者将在离心机上旋转1小时，对照受试者将在离心机上旋转1小时而不旋转。科学家们将在卧床休息之前、期间和之后测量许多身体系统的功能，以了解宇航员的身体在未来的太空飞行中如何在失重状态下发生变化，以及如何利用人工重力来保护宇航员免受身体变化的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test how a force created by spinning the space craft could be used to replace gravity during long space flights. For this study, the ¿artificial gravity¿ will be created by spinning subjects on a human centrifuge and space flight will be simulated by prolonged bed rest. Bed rest with the head tilted down slightly below the feet is a good way for researchers to imitate the changes that occur in a person's body while traveling in space without gravity. In this study, subjects will be confined to 21 days of 24 hours a day bed rest, with the head tilted down slightly to experience some of the changes an astronaut's body goes through during 21 days of weightless space flight. During those 21 days subjects will not get out of bed; however, once a day they will be wheeled on a gurney to the centrifuge facility. There, treatment subjects will spend 1 hr spinning on the centrifuge and control subjects will spend 1 hr on the centrifuge without spinning. Scientists will measure the functioning of many of the body systems before, during, and after bed rest to learn how an astronaut's body will change in weightlessness during space flight in the future, and how artificial gravity might be used to protect astronauts from some of the changes their bodies go through.