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New precursors for diverse radical reactions enabled by potent photoreductants

New precursors for diverse radical reactions enabled by potent photoreductants
强效光还原剂实现多种自由基反应的新前体
批准号:
10600016
负责人:
Zachary Kimble Wickens
金额:
$30.51万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-04-05 至 2027-01-31

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英文摘要
PROJECT SUMMARY/ABSTRACT Radical intermediates generated through chemoselective single electron reduction have broad utility in the development of valuable synthetic transformations. As a consequence, photoredox catalysis, which induces single election transfer with exceptional selectivity for radical pathways, has shown great promise as an enabling technology in biomedical research. However, the design underpinning current photoredox catalysts limits the accessible reduction potentials and excludes numerous abundant feedstocks. The selective generation of radical intermediates from substrates inert towards conventional photoredox catalysis is a long- standing challenge with no general solutions. This proposal is based on the discovery that electrochemistry can generate new radical anion photocatalysts that are exceptionally potent excited state reductants but retain the selectivity of typical photoredox catalysts. We will study how these new catalysts can be exploited to develop radical coupling reactions infeasible with modern synthetic tactics. The three specific aims of this research center on exploring distinct but interwoven aspects of this new catalytic platform. Aim 1. We are exploring the ability to generate and exploit the reactivity of aryl radicals from aryl chlorides Aim 2. We are exploring the ability to engage carbonyl compounds in reductive radical coupling reactions Aim 3. We are exploring operationally simple strategies to access radical anion photocatalysts These methods address long-standing challenges in a fundamental class of organic reactions, reductions. These new catalytic systems will offer an expanded and diversified pool of starting materials from which the next generation of drugs and molecular probes will be discovered.
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electrochemical dication pool: a new strategy to couple alkenes and abundant nucleophiles
  • 批准号:
    10635132
  • 项目类别:
  • 资助金额:
    $29.1万
  • 财政年份:
    2023
  • 负责人:
    Zachary Kimble Wickens
  • 依托单位:
Facile Access to Quaternary Stereocenters Through Anion Binding Catalysis
  • 批准号:
    9315838
  • 项目类别:
  • 资助金额:
    $4.9万
  • 财政年份:
    2015
  • 负责人:
    Zachary Kimble Wickens
  • 依托单位:
Facile Access to Quaternary Stereocenters Through Anion Binding Catalysis
  • 批准号:
    9514554
  • 项目类别:
  • 资助金额:
    $0.16万
  • 财政年份:
    2015
  • 负责人:
    Zachary Kimble Wickens
  • 依托单位:
海外基金