Restoring Northeast Cape for the Health and Well-Being of the Yupik Communities of St. Lawrence Island, Alaska

恢复东北角，以促进阿拉斯加圣劳伦斯岛尤皮克社区的健康和福祉

• 批准号: 10600044
• 负责人: Charles Loren Buck
• 金额: $ 55.48万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-20 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600044
• 关键词: Address; Advocate; Affect; Alaska; Arctic Regions; Biological; Biota; Blood; Body Burden; Collaborations; Communities; Computerized Medical Record; Consultations; Consumption; DNA Methylation; DNA Repair; DNA biosynthesis; Data; Decision Making; Endocrine; Engineering; Ensure; Equity; Exhibits; Exposure to; Fishes; Food; Gasterosteidae; Glean; Goals; Guidelines; Hair; Hazardous Waste; Health; Health protection; Histopathology; Hormones; Human; Hypothyroidism; Indigenous; Ingestion; Inhalation; International; Intervention; Investigation; Knowledge; Left; Measurement; Mercury; Metabolic; Military Personnel; Modeling; Monitor; Names; Nature; Organ; Outcome; Participant; Personal Satisfaction; Persons; Pesticides; Physiological; Policies; Polychlorinated Biphenyls; Public Health; Recording of previous events; Research; Sampling; Scientific Advances and Accomplishments; Sentinel; Serum; Signal Transduction; Site; Soil; Source; St. Lawrence Island; Tissue-Specific Gene Expression; Vitellogenins; War; Water; Work; Yup' ik; air sampling; cancer risk; community based participatory research; estrogenic; exposure pathway; health assessment; improved; indigenous community; male; member; organochlorine pesticide; persistent organic pollutants; pollutant transport; remediation

Our previous community-based participatory research at Northeast Cape (NEC) on St. Lawrence Island (SLI) found elevated levels of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and mercury (Hg) in sediments and biota within the watershed at the formerly used defense (FUD) site. We found elevated OCPs and PCBs in serum of the SLI people due to both long-range transport and military-derived sources, with the highest levels of PCBs in people who have traditional and familial connections with NEC, including subsistence. Concentrations of persistent organic pollutants (POPs) in our resident fish model, the stickleback, closely mirror concentrations in the blood serum of SLI residents, indicating their efficacy as sentinel species on SLI. Despite extensive remediation at NEC, short-lived lower trophic level fish in the Suqitughneq (Suqi) River remain contaminated with PCBs, OCPs, and Hg originating from the FUD site, at levels that exceed EPA fish consumption guidelines for cancer risk. Elevated contaminant levels and disrupted health in Suqi River fish indicate potential health threats for residents and that site remediation is incomplete. Our overarching goal is to advance scientific understanding of the exposure pathways and long-term human health consequences associated with contaminant exposure from FUD sites and inform interventions necessary to protect the health and long-term well-being of the people of SLI as they re-establish their traditional community at NEC. In Aim 1, we propose to build on our prior discoveries and continue our collaboration with the communities of SLI to investigate potential exposure pathways and biological impacts of persistent contamination associated with the FUD site at NEC on SLI. We will analyze PCBs, OCPs, and Hg in the water of the Suqi and Tapisaggak rivers, as well as in traditional foods and air samples to assess ingestion and inhalation as potential exposure pathways. We will build on work with stickleback as a sentinel species to determine biological effects of contaminants on endocrine function and organ-specific histopathology. In Aim 2, we will characterize and quantify body burden of contaminants, and linkages to health outcomes, in people associated with NEC. In Aim 3, we will inform decisions and interventions to protect the health of the people of SLI and enable re- establishment of the traditional community at NEC. We will provide information that will lead to improved remediation, provide data and traditional knowledge to inform public health consultations and assessments, and develop a community-based public health action plan and interventions to protect health, ensure equity in decision-making, and restore the NEC community. This study will have local and circumpolar arctic implications for Indigenous communities. Locally, we will provide data and implement actions necessary for re- establishing the community at NEC. Given that thousands of such Cold War military sites exist throughout the Arctic, often in close proximity to Indigenous communities, our project may serve as a model for environmental and health monitoring and policy action by other Arctic Indigenous Peoples.

我们以前在圣劳伦斯岛（SLI）的东北角（NEC）进行的基于社区的参与式研究 发现多氯联苯（PCBs）、有机氯农药（OCPs）和汞的含量升高 (Hg)在沉积物和生物群内的分水岭在以前使用的防御（FUD）网站。我们发现 由于长距离运输和军事来源，SLI人血清中的OCPs和PCBs， 与NEC有传统和家族联系的人体内多氯联苯含量最高，包括 维持生计。在我们的常驻鱼类模型，棘鱼， 密切反映了SLI居民血清中的浓度，表明其作为哨兵物种的功效 关于SLI尽管NEC采取了广泛的补救措施，但Suqitughneq（Suqi） 河流仍然受到来自FUD场地的多氯联苯、有机氯农药和汞的污染，污染水平超过EPA 鱼类消费指南的癌症风险。污染物水平升高，破坏了苏奇河鱼类的健康 表明对居民健康有潜在威胁，而且现场补救工作尚未完成。我们的首要目标是 促进对接触途径和长期人类健康后果的科学认识 与FUD场所的污染物暴露相关，并告知保护健康所需的干预措施 这将有助于SLI人民在NEC重建其传统社区时的长期福祉。在目标1中， 我们建议以我们先前的发现为基础，继续与SLI社区合作， 调查与化学品相关的持久性污染的潜在接触途径和生物影响， FUD网站在NEC上SLI。我们将分析苏旗河和塔皮萨加克河水中的多氯联苯、有机氯农药和汞， 以及在传统食品和空气样本中，以评估摄入和吸入的潜在接触 途径。我们将以棘鱼为哨兵物种， 污染物对内分泌功能和器官特异性组织病理学的影响。在目标2中，我们将描述和 量化污染物的身体负担，以及与NEC相关人群的健康结果的联系。在Aim中 3、我们将为决策和干预提供信息，以保护SLI人民的健康，并使他们能够重新 在全国选举委员会建立传统社区。我们将提供信息，将导致改善 提供数据和传统知识，为公共卫生咨询和评估提供信息， 制定以社区为基础的公共卫生行动计划和干预措施，以保护健康，确保公平， 恢复决策，并恢复NEC社区。这项研究将有本地和环极北极 对土著社区的影响。在当地，我们将提供数据并采取必要行动， 在NEC建立社区。考虑到冷战时期的数千个军事基地， 北极，往往在靠近土著社区，我们的项目可以作为一个模式，为环境 以及其他北极土著人民的健康监测和政策行动。