Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence Island

保护子孙后代的健康：评估和预防接触内分泌干扰性阻燃化学品

• 批准号: 9384662
• 负责人: Charles Loren Buck
• 金额: $ 56.17万
• 依托单位: ALASKA COMMUNITY ACTION ON TOXICS (ACAT)
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9384662
• 关键词: Address; Adult; Alaska; Alaska Native; Animal Model; Animals; Arctic Regions; Biological; Blood; Body Burden; Chemicals; Child; Child Development; Child health care; Collaborations; Communities; DNA Methylation; DNA Repair; DNA biosynthesis; Deposition; Development; Diet; Down-Regulation; Early Diagnosis; Early Intervention; Educational process of instructing; Educational workshop; Endocrine; Endocrine Disruptors; Endocrine disruption; Endocrinology; Environmental Health; Environmental Risk Factor; Esters; Exposure to; Female; Fishes; Flame Retardants; Food Contamination; Future; Future Generations; Gasterosteidae; Gene Expression; Gene Expression Profile; Genes; Health; Health Fairs; Histologic; Histology; Histopathology; House Dust; Household; Household Products; Human; Hypothyroidism; Incidence; Indigenous; Institutes; International; Intervention; Island; Knowledge; Lead; Level of Evidence; Link; Malignant Neoplasms; Measures; Methods; Military Personnel; Modeling; Monitor; Nail plate; Native-Born; Organ; Organophosphates; Outcome; Parents; Pathology; Physicians; Planet Earth; Poison; Policies; Polychlorinated Biphenyls; Population; Production; Public Health; Recommendation; Reporting; Research Institute; Research Project Grants; Risk; Scientist; Sentinel; Serum; Sexual Development; Site; Techniques; Thyroid Diseases; Time; Tissue-Specific Gene Expression; Tissues; Training; Work; Yup' ik; college; community based participatory research; estrogenic activity; experience; exposure pathway; exposure route; geographic difference; hazard; health disparity; human data; improved; innovation; male; member; minimally invasive; outreach; persistent organic pollutants; pollutant transport; polybrominated diphenyl ether; prevent; public health intervention; reproductive; sex development disorder; stable isotope; symposium; teacher; tool; transcriptome; transcriptomics; webinar

Project Summary/Abstract The objectives of this community-based participatory research (CBPR) project are to investigate exposures, endocrine effects, and mechanisms of developmental disruption associated with legacy contaminants and emerging flame retardant chemicals in two Yupik communities on St. Lawrence Island (SLI) in arctic Alaska. The Arctic is subject to atmospheric deposition of globally-distilled persistent organic pollutants (POPs), acting as a hemispheric sink for POPs that are transported from lower latitudes. Thus, the Arctic is significant as an indicator region and contains some of the most highly contaminated animals and people in the world. This study addresses a primary public health concern of the people of SLI by focusing on the levels and effects of legacy and emerging contaminants on the development of children in an arctic indigenous population that is vulnerable, underserved, and experiences significant health disparities. Other studies have shown that young children are more highly exposed than adults. Using innovative and minimally invasive techniques, we will assess exposures of children to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and emerging halogenated and non-halogenated organophosphate flame retardants. We will quantify PCBs and flame retardant chemicals in household dust, known to be an important exposure route. We will assess relationships among contaminant levels and evidence of health disruption via transcriptomics and endocrinology. We will use chemical concentrations in household dust and utilization of a subsistence diet as determined by stable isotope analysis to assess exposure pathways of these compounds. In order to understand the mechanistic basis of developmental disruption, and to have a reference for interpretation of human data, we will monitor patterns of gene expression, endocrinology, and histology of our resident fish model, the stickleback, from both contaminated and reference sites. Collectively, we will increase our understanding of routes of exposure, endocrine disruption, and effects on the transcriptome of Yupik children exposed to high levels of PCBs and flame retardant chemicals. This study provides an opportunity to investigate the levels of PBDEs and emerging flame retardants in nails and blood in relation to health outcomes of arctic indigenous children for the first time. Our CBPR project will also empower SLI communities with the knowledge and tools they need to address important health disparities in their communities. Our results will inform public health interventions and improve health outcomes of arctic children broadly. Furthermore, discovery of bioindicators relevant to early detection of developmental disruption will enable early intervention and improve health outcomes. Importantly, we will build capacity through our CBPR approach, public health interventions, and policy outreach, which will mitigate future exposure of SLI children to toxic chemicals.

项目概要/摘要 这个基于社区的参与性研究 (CBPR) 项目的目标是调查暴露情况、 内分泌影响以及与遗留污染物和相关的发育破坏机制 北极阿拉斯加圣劳伦斯岛 (SLI) 两个尤皮克社区的新兴阻燃化学品。 北极地区受到全球蒸馏的持久性有机污染物（POP）的大气沉积影响， 作为从低纬度地区输送的持久性有机污染物的半球汇。因此，北极作为一个重要的 指标区域，包含世界上一些污染最严重的动物和人类。这 研究通过关注 SLI 人群的水平和影响来解决 SLI 人群的主要公共卫生问题 遗留污染物和新出现的污染物对北极土著居民儿童发育的影响 弱势群体、服务不足、健康状况存在显着差异。其他研究表明，年轻人 儿童比成人接触的程度更高。使用创新和微创技术，我们将 评估儿童接触多氯联苯 (PCB)、多溴二苯醚 (PBDE)、 以及新兴的卤化和非卤化有机磷酸酯阻燃剂。我们将量化 PCB 家庭灰尘中的阻燃化学物质，已知是重要的暴露途径。我们将评估 通过转录组学和 内分泌学。我们将利用家庭灰尘中的化学浓度和自给饮食作为 通过稳定同位素分析确定，以评估这些化合物的暴露途径。为了 了解发育障碍的机制基础，并为解释提供参考 人类数据，我们将监测常驻鱼类的基因表达、内分泌和组织学模式 来自污染地点和参考地点的刺鱼模型。我们将共同提高我们的 了解暴露途径、内分泌干扰以及对尤皮克儿童转录组的影响 暴露于高含量的多氯联苯和阻燃化学品。这项研究提供了一个机会 调查指甲和血液中多溴联苯醚和新兴阻燃剂的含量与健康的关系 北极土著儿童的成果首次。我们的 CBPR 项目还将为 SLI 社区提供支持 拥有解决社区中重要健康差异所需的知识和工具。我们的 结果将为公共卫生干预措施提供信息，并广泛改善北极儿童的健康状况。 此外，发现与早期检测发育障碍相关的生物指示剂将使早期发现成为可能。 干预和改善健康结果。重要的是，我们将通过 CBPR 方法建设能力， 公共卫生干预措施和政策推广，这将减少 SLI 儿童未来接触有毒物质的风险 化学品。