Leadership Administrative Core

领导行政核心

• 批准号: 10599819
• 负责人: SHERRY ANN MCKEE
• 金额: $ 46.78万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-10 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599819
• 关键词: Advanced Development; Alcohol consumption; Award; Biosensor; Clinical Research; Collection; Communities; Consultations; Darkness; Data; Data Collection; Development; Doctor of Philosophy; Education; Education and Outreach; Ensure; Environment; FDA approved; Funding; Goals; Health Personnel; Human Resources; Infrastructure; Institution; Lead; Leadership; Mentorship; Office of Administrative Management; Pharmaceutical Preparations; Pilot Projects; Policies; Principal Investigator; Public Health; Research; Research Personnel; Resources; Role; Sex Differences; Side; Structure; Teacher Professional Development; Therapeutic; Training; Translating; Translations; Woman; Work; addiction; alcohol abuse therapy; alcohol use disorder; career; design; drinking; faculty support; gender difference; improved; meetings; outreach; preclinical study; sex; synergism; translational pipeline; translational potential

The purpose of the Leadership Administrative Core is to provide the overall interdisciplinary and translational scientific planning and coordination for the Yale-SCORE, as it develops sex-appropriate therapeutics for the treatment of alcohol use disorders (AUD) using the ‘dark side of addiction’ as a guiding framework. Specifically the Core, through its structure and resources, will: 1) manage the ongoing conceptual integration of Center personnel to capitalize on the synergies and translational opportunities of the Yale- SCORE, 2) support the development of new collaborative research within the Yale-SCORE and with other Yale Centers and SCOREs at other institutions, 3) organize regular planning meetings to promote dynamic exchange among investigators regarding new scientific findings and their implications for sex-appropriate medications development, 4) facilitate the work of the Projects, Pilots, and Cores through fiscal and administrative oversight, solicit, review and fund meritorious Pilot Projects, oversee the distribution of research- related resources; provide input into the design of a core battery, and the collection of biosensor data to maximize the scientific yield of the Center, and 5) educate and inform our communities and function as an institutional, regional, and national resource to invigorate the study of sex and alcohol use. Our approach is designed to ensure that the Project Leads, investigators, collaborators, and trainees operate in an integrated scientific environment that creates a coordinated interdisciplinary translational team effort, focused on advancing the development of sex-appropriate treatment for AUD. The goals of the Core will be accomplished through the following specific aims. AIM 1: Provide integrated scientific research planning and oversight among the Yale-SCORE’s Principal Investigator, Deputy Director, and Executive Committee, with targeted consultation from the External Scientific Advisory Board. AIM 2: Ensure fiscal and administrative oversight to the Yale-SCORE Projects and Pilot Projects. AIM 3: Be an institutional, regional, and national resource to invigorate and galvanize the study of sex differences in relation to alcohol use across T1 to T4 translation by providing expert consultation, supporting faculty training awards, leveraging national data on sex and alcohol use to inform treatment and policy, and by providing outreach and dissemination to local community, regional, and national audiences.

领导行政核心的目的是提供全面的跨学科和 翻译的科学规划和协调耶鲁评分，因为它制定了性别适当的 使用“成瘾的黑暗面”作为指导治疗酒精使用障碍（AUD）的疗法 框架.具体而言，核心将通过其结构和资源：1）管理正在进行的概念性工作， 整合中心人员，利用耶鲁大学的协同效应和翻译机会- 2）支持在耶鲁-SCORE内部以及与耶鲁其他大学合作开展新的合作研究。 中心和SCORE在其他机构，3）组织定期规划会议，以促进动态 研究人员之间就新的科学发现及其对性别适当性的影响进行交流 药物开发，4）通过财政和 行政监督，征求，审查和资助有价值的试点项目，监督研究的分配- 相关资源;为核心电池的设计提供输入，并收集生物传感器数据， 最大限度地提高中心的科学产量，5）教育和告知我们的社区，并作为一个 机构，区域和国家资源，以振兴性和酒精使用的研究。我们的做法是 旨在确保项目负责人、调查人员、合作者和受训人员在一个综合的环境中运作， 科学的环境，创造一个协调的跨学科翻译团队的努力，重点是 促进开发适合性别的AUD治疗方法。核心的目标将会实现 通过以下具体目标。目标1：提供综合科学研究规划和监督 在耶鲁-SCORE的首席研究员，副主任和执行委员会，有针对性的 外部科学咨询委员会的咨询。目标2：确保财政和行政监督， Yale-SCORE项目和试点项目目标3：成为机构、区域和国家资源， 通过以下方式激励和激励跨T1到T4翻译的酒精使用性别差异研究： 提供专家咨询，支持教师培训奖，利用国家性和酒精数据 用于为治疗和政策提供信息，并向当地社区、区域 和全国观众。