Developing Methodology to examine causal mediation of Time-Varying Effects in Smoking Cessation Treatments
开发方法来检查戒烟治疗中时变效应的因果调节
基本信息
- 批准号:10738681
- 负责人:
- 金额:$ 14.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project will examine new methods for understanding time-varying causal mediation effects in smoking
cessation interventions. Mediation occurs when an independent variable (e.g., smoking cessation intervention)
has an effect on an outcome (e.g., smoking abstinence) through a third variable (e.g., reduction in craving). In
other words, we will develop new ways to understand the mechanisms by which smoking cessation
interventions cause changes in people's smoking behavior, and how these effects vary over time.
Understanding how interventions have their effect is key to designing more powerful, efficient interventions. To
improve smoking cessation interventions, this proposal focuses on improving methods for the understanding of
how people stop smoking and continue to abstain from smoking following a smoking cessation intervention.
More broadly, the methods that we propose to develop will help us understand what causes behavioral
interventions to affect people's engagement in and maintenance of healthy behaviors.
We will develop and extend methods for analyzing intensive longitudinal data and conducting mediation
analysis to better study time-varying effects, which refer to effects of one variable on another that change (i.e.,
strengthen or diminish) over time. We will extend methods, based on the potential outcomes framework for
causal inference, to draw more valid causal inferences about time-varying effects in mediation and then apply
these methods to two smoking cessation intervention studies. First, we will use ecological momentary
assessment (EMA) data that asked people about their craving, mood, and smoking abstinence while they were
enrolled in a randomized controlled trial of combination nicotine replacement therapy, the nicotine patch alone,
and varenicline to develop mediation models in which the effect of the various study drugs on smoking
abstinence is mediated by cravings or mood. These effects may vary over time. For example, a study drug
may be very effective at reducing cravings shortly after the quit day, but the effect may weaken over time.
Second, using data from pedometers, we will assess the effect of a physical activity/ smoking cessation
intervention on daily step count and whether increases in daily step counts in turn have an effect on smoking
cessation. We will disseminate the methods we develop in user-friendly software (e.g., R packages), journal
articles, and conference presentations and workshops that are accessible to behavioral intervention
researchers. Methods and findings will ultimately allow researchers to understand how their interventions work.
With this knowledge, they will be able to design more efficacious and cost-effective interventions for smoking
cessation by targeting the most relevant mediator(s) at the most relevant time.
该项目将研究了解吸烟随时间变化的因果中介效应的新方法
戒烟干预措施。当自变量(例如戒烟干预)出现时,就会发生中介
通过第三个变量(例如,烟瘾的减少)对结果(例如,戒烟)产生影响。在
换句话说,我们将开发新的方法来了解戒烟的机制
干预措施会导致人们的吸烟行为发生变化,以及这些影响如何随时间变化。
了解干预措施如何发挥作用是设计更强大、更有效的干预措施的关键。到
改善戒烟干预措施,该提案的重点是改进了解吸烟的方法
人们如何在戒烟干预后戒烟并继续戒烟。
更广泛地说,我们建议开发的方法将帮助我们了解导致行为的原因
影响人们参与和维持健康行为的干预措施。
我们将开发和扩展分析密集纵向数据和进行调解的方法
分析以更好地研究时变效应,这是指一个变量对另一个变化的变量的影响(即,
随着时间的推移,增强或减弱。我们将根据潜在结果框架扩展方法
因果推断,对调解中的时变效应得出更有效的因果推断,然后应用
这些方法适用于两项戒烟干预研究。首先,我们将使用生态瞬间
评估 (EMA) 数据,询问人们吸烟时的烟瘾、情绪和戒烟情况
参加了一项联合尼古丁替代疗法(单独使用尼古丁贴片)的随机对照试验,
和伐尼克兰开发中介模型,其中各种研究药物对吸烟的影响
禁欲是由渴望或情绪调节的。这些影响可能会随着时间的推移而变化。例如,研究药物
戒烟日后不久可能会非常有效地减少烟瘾,但效果可能会随着时间的推移而减弱。
其次,使用计步器的数据,我们将评估体力活动/戒烟的效果
对每日步数的干预以及每日步数的增加是否会对吸烟产生影响
停止。我们将在用户友好的软件(例如 R 包)、期刊中传播我们开发的方法
可以进行行为干预的文章、会议演示和研讨会
研究人员。方法和研究结果最终将使研究人员了解他们的干预措施是如何发挥作用的。
有了这些知识,他们将能够设计出更有效且更具成本效益的吸烟干预措施
通过在最相关的时间针对最相关的调解者来停止。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Varying Coefficient Mediation Model and Application to Analysis of Behavioral Economics Data.
变系数中介模型及其在行为经济学数据分析中的应用
- DOI:10.1080/07350015.2021.1971089
- 发表时间:2022
- 期刊:
- 影响因子:3
- 作者:Liao, Yujie;Liu, Jingyuan;Coffman, Donna L.;Li, Runze
- 通讯作者:Li, Runze
Time-Varying Mediation of Pharmacological Smoking Cessation Treatments on Smoking Lapse via Craving, Cessation Fatigue, and Negative Mood.
药物戒烟治疗通过渴望、戒烟疲劳和消极情绪对戒烟的时变调节。
- DOI:10.1093/ntr/ntac068
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Chakraborti,Yajnaseni;Coffman,DonnaL;Piper,MeganE
- 通讯作者:Piper,MeganE
Variable selection for causal mediation analysis using LASSO-based methods.
- DOI:10.1177/0962280221997505
- 发表时间:2021-06
- 期刊:
- 影响因子:2.3
- 作者:Ye Z;Zhu Y;Coffman DL
- 通讯作者:Coffman DL
Variable selection for partially linear models via Bayesian subset modeling with diffusing prior
- DOI:10.1016/j.jmva.2021.104733
- 发表时间:2021-02-24
- 期刊:
- 影响因子:1.6
- 作者:Wang,Jia;Cai,Xizhen;Li,Runze
- 通讯作者:Li,Runze
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Donna Lynn Coffman其他文献
Donna Lynn Coffman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Donna Lynn Coffman', 18)}}的其他基金
Developing Methodology to examine causal mediation of Time-Varying Effects in Smoking Cessation Treatments
开发方法来检查戒烟治疗中时变效应的因果调节
- 批准号:
9754035 - 财政年份:2018
- 资助金额:
$ 14.46万 - 项目类别:
Developing Methodology to examine causal mediation of Time-Varying Effects in Smoking Cessation Treatments
开发方法来检查戒烟治疗中时变效应的因果调节
- 批准号:
9982240 - 财政年份:2018
- 资助金额:
$ 14.46万 - 项目类别:
Developing Methodology to examine causal mediation of Time-Varying Effects in Smoking Cessation Treatments
开发方法来检查戒烟治疗中时变效应的因果调节
- 批准号:
10223232 - 财政年份:2018
- 资助金额:
$ 14.46万 - 项目类别:
Novel Methods to Identify Momentary Risk States for Stress & Physical Inactivity
识别瞬时压力风险状态的新方法
- 批准号:
8828888 - 财政年份:2014
- 资助金额:
$ 14.46万 - 项目类别:
Causal Inference for Mediation Models in Substance Abuse Prevention Research
药物滥用预防研究中中介模型的因果推断
- 批准号:
7638074 - 财政年份:2009
- 资助金额:
$ 14.46万 - 项目类别:
Causal Inference for Mediation Models in Substance Abuse Prevention Research
药物滥用预防研究中中介模型的因果推断
- 批准号:
7779398 - 财政年份:2009
- 资助金额:
$ 14.46万 - 项目类别:
Casual Mediation in Non-Randomized and Multilevel Intervention Research
非随机和多层次干预研究中的随意调解
- 批准号:
8525368 - 财政年份:
- 资助金额:
$ 14.46万 - 项目类别:
Casual Mediation in Non-Randomized and Multilevel Intervention Research
非随机和多层次干预研究中的随意调解
- 批准号:
8706109 - 财政年份:
- 资助金额:
$ 14.46万 - 项目类别:
Casual Mediation in Non-Randomized and Multilevel Intervention Research
非随机和多层次干预研究中的随意调解
- 批准号:
8002610 - 财政年份:
- 资助金额:
$ 14.46万 - 项目类别:
Casual Mediation in Non-Randomized and Multilevel Intervention Research
非随机和多层次干预研究中的随意调解
- 批准号:
8379092 - 财政年份:
- 资助金额:
$ 14.46万 - 项目类别:
相似海外基金
SaTC: CORE: Small: An evaluation framework and methodology to streamline Hardware Performance Counters as the next-generation malware detection system
SaTC:核心:小型:简化硬件性能计数器作为下一代恶意软件检测系统的评估框架和方法
- 批准号:
2327427 - 财政年份:2024
- 资助金额:
$ 14.46万 - 项目类别:
Continuing Grant
A methodology to connect functionalized gonadal constructs to a chick embryo through mechanically induced blood vessels from an egg
一种通过鸡蛋机械诱导血管将功能化性腺结构连接到鸡胚胎的方法
- 批准号:
24K15741 - 财政年份:2024
- 资助金额:
$ 14.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CAS: Developing Data-Driven, Automated Methodology to Understand and Control Light-Driven Catalytic Processes
CAS:开发数据驱动的自动化方法来理解和控制光驱动的催化过程
- 批准号:
2350257 - 财政年份:2024
- 资助金额:
$ 14.46万 - 项目类别:
Continuing Grant
スマートシティのエコシステム構築メソドロジー(methodology)
智慧城市生态系统构建方法论
- 批准号:
24K05098 - 财政年份:2024
- 资助金额:
$ 14.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mindset Dynamics: Using the Perception Clarity Methodology (PCM) to shift perceptions
心态动态:使用感知清晰度方法 (PCM) 来转变认知
- 批准号:
ES/Y011015/1 - 财政年份:2024
- 资助金额:
$ 14.46万 - 项目类别:
Research Grant
Supporting Mental Health in Young People: Integrated Methodology for cLinical dEcisions and evidence-based interventions
支持年轻人的心理健康:临床决策和循证干预的综合方法
- 批准号:
10072391 - 财政年份:2023
- 资助金额:
$ 14.46万 - 项目类别:
EU-Funded
MEGASKILLS [MEthodology of Psycho-pedagogical, Big Data and Commercial Video GAmes procedures for the European SKILLS Agenda Implementation]
MEGASKILLS [欧洲技能议程实施的心理教育学、大数据和商业视频游戏程序的方法]
- 批准号:
10069843 - 财政年份:2023
- 资助金额:
$ 14.46万 - 项目类别:
EU-Funded
Development and Implementation of Participatory Urban Design Methodology for Introducing Climate Change Mitigation and Adaptation Measures
制定和实施参与式城市设计方法,引入气候变化减缓和适应措施
- 批准号:
23H01578 - 财政年份:2023
- 资助金额:
$ 14.46万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Curriculum Development Methodology for Inclusive Physical Education that Respects Diversity
尊重多样性的包容性体育课程开发方法
- 批准号:
23K02486 - 财政年份:2023
- 资助金额:
$ 14.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Agile development methodology of matched synthetic control for Bayesian trials in the era of genomic medicine
基因组医学时代贝叶斯试验匹配合成控制的敏捷开发方法
- 批准号:
2890403 - 财政年份:2023
- 资助金额:
$ 14.46万 - 项目类别:
Studentship