Improving treatment of cardiovascular risk factors in childhood cancer survivors

改善儿童癌症幸存者心血管危险因素的治疗

基本信息

  • 批准号:
    10603027
  • 负责人:
  • 金额:
    $ 48.79万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-03-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

ABSTRACT Children and adolescents diagnosed with cancer now have on average >80% 5-year survival. However, premature cardiovascular (CV) disease has become the leading non-cancer cause of late mortality among childhood cancer survivors. Our existing work has shown that traditional CV risk factors such as hypertension, dyslipidemia, insulin resistance/diabetes remain very important, by increasing (in synergistic fashion) the risk of major CV events such as ischemic heart disease and heart failure. However, the existing research has been limited by misclassification of CV risk factor status (i.e., when defined by self-report or medication usage alone), including issues with both underdiagnosis (i.e., people with these risk factors present but who are unaware) and uncertainty of disease control (i.e., potential undertreatment). This proposal will utilize the largest, best characterized childhood cancer survivor cohort in the world, the Childhood Cancer Survivor Study (CCSS; n=24,466), a NCI-funded resource. We will use CCSS-derived validated risk prediction algorithms to select survivors at high risk of serious heart disease (n=800) based on past cancer treatment exposures. Among these 800 survivors, we propose to determine the magnitude of underdiagnosis and undertreatment of hypertension, dyslipidemia, and diabetes via in-person (home-based) measurements supplemented by medical record review. We predict that around 60% of survivors (n~480) will be underdiagnosed or undertreated with respect to one of these three CV risk factors. Survivors who are underdiagnosed or undertreated will then be eligible to participate in a 1-year long randomized controlled trial, where we will measure the efficacy of an Institute of Medicine (IOM) recommended personalized survivorship care plan (SCP) emphasizing CV risk, supplemented by a remotely delivered clinician-led self-management counseling intervention, to improve control of these three CV risk factors (i.e., reduce rates of undertreated hypertension, dyslipidemia, and diabetes). Survivors randomized to the control arm can receive the intervention on a delayed basis. Finally, our proposal seeks to better understand barriers among survivors and their primary healthcare providers that contribute to CV risk factor undertreatment. Knowledge derived from this study will improve the assessment and treatment of important CV risk factors in this high risk population. The proposed intervention, if successful, will be disseminable and low cost, and will have the potential to improve health and reduce mortality in these younger adults who live the majority of their lives as cancer survivors at increased risk of serious CV disease.
摘要

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Eric Jessen Chow其他文献

Eric Jessen Chow的其他文献

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{{ truncateString('Eric Jessen Chow', 18)}}的其他基金

SALSA - Study of Active Lifestyle Activation
SALSA - 积极生活方式激活研究
  • 批准号:
    10910785
  • 财政年份:
    2021
  • 资助金额:
    $ 48.79万
  • 项目类别:
SALSA - Study of Active Lifestyle Activation
SALSA - 积极生活方式激活研究
  • 批准号:
    10285925
  • 财政年份:
    2021
  • 资助金额:
    $ 48.79万
  • 项目类别:
SALSA - Study of Active Lifestyle Activation
SALSA - 积极生活方式激活研究
  • 批准号:
    10601394
  • 财政年份:
    2021
  • 资助金额:
    $ 48.79万
  • 项目类别:
Improving cancer survivorship care delivery in Latino survivors: telehealth & lay health educators
改善拉丁裔幸存者的癌症生存护理服务:远程医疗
  • 批准号:
    10603034
  • 财政年份:
    2021
  • 资助金额:
    $ 48.79万
  • 项目类别:
Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
右雷佐生与蒽环类药物相关心肌病的预防
  • 批准号:
    9220377
  • 财政年份:
    2017
  • 资助金额:
    $ 48.79万
  • 项目类别:
Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
右雷佐生与蒽环类药物相关心肌病的预防
  • 批准号:
    9891037
  • 财政年份:
    2017
  • 资助金额:
    $ 48.79万
  • 项目类别:
Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy
右雷佐生与蒽环类药物相关心肌病的预防
  • 批准号:
    10656913
  • 财政年份:
    2017
  • 资助金额:
    $ 48.79万
  • 项目类别:
Analysis of Morbidity and Mortality Among Hematopoietic Cell Transplantation Surv
造血细胞移植存活率及死亡率分析
  • 批准号:
    8641672
  • 财政年份:
    2013
  • 资助金额:
    $ 48.79万
  • 项目类别:
Analysis of Morbidity and Mortality Among Hematopoietic Cell Transplantation Surv
造血细胞移植存活率及死亡率分析
  • 批准号:
    8513119
  • 财政年份:
    2013
  • 资助金额:
    $ 48.79万
  • 项目类别:
Determinants of late cardiovascular morbidity among survivors of hematopoietic ce
造血细胞癌幸存者晚期心血管发病的决定因素
  • 批准号:
    8893907
  • 财政年份:
    2011
  • 资助金额:
    $ 48.79万
  • 项目类别:

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