Novel Sample Introduction Methodologies for Molecular Rotational Resonance (MRR) Spectroscopy

分子旋转共振 (MRR) 光谱的新样品引入方法

• 批准号: 10603098
• 负责人: Voislav Blagojevic
• 金额: $ 100.63万
• 依托单位: BRIGHTSPEC, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-15 至 2025-03-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10603098
• 关键词: Acceleration; Achievement; Acoustics; Adoption; Affect; Alanine; Amino Acids; Amino Sugars; Applications Grants; Area; Award; Basic Science; Biological; Biological Monitoring; Collaborations; Collection; Complex Mixtures; Coupling; Cysteine; Detection; Development; Dipeptides; Environmental Monitoring; Environmental Pollutants; Evaluation; Feedback; Generations; Grant; Heart; Histidine; Hour; Individual; Isomerism; Laboratory Research; Laser vaporization; Lasers; Learning; Legal patent; Letters; Marketing; Mass Spectrum Analysis; Measurement; Measures; Methodology; Methods; Molecular; Molecular Structure; Natural Products; Nebulizer; Nuclear Magnetic Resonance; Paper; Peer Review; Peptides; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Preparation; Process; Proline; Research; Research Personnel; Risk; Sampling; Small Business Innovation Research Grant; Solid; Solvents; Specificity; Spectrum Analysis; Speed; Structure; System; Techniques; Technology; Temperature; Testing; Thick; Time; Toxin; Ultrasonics; United States National Institutes of Health; Universities; Validation; Vial device; Volatilization; Work; biological systems; commercial launch; commercialization; cost; design; drug discovery; improved; innovation; insight; instrument; manufacture; metabolomics; method development; novel; operation; prospective; prototype; research and development; screening; small molecule; software development; software systems; sugar; vaporization

BrightSpec Inc. NIH SBIR Application Project Summary Novel Sample Introduction Methodologies for Molecular Rotational Resonance (MRR) Spectroscopy NIH SBIR Direct to Phase II BrightSpec, Inc. Project Summary This project proposes to develop a new analyte sampling technique for Molecular Rotational Resonance (MRR) spectrometers for the volatilization of solid phase analytes. The proposed system, Laser Induced Acoustic Desorption (LIAD), will enable a large number of important compounds to be accessible by MRR, enhancing our understanding in several important areas of research and accelerating pharmaceutical development. The resulting expansion of sampling range and corresponding utility of this valuable technique will greatly accelerate the adoption of MRR in important areas of research and development. MRR is a spectroscopic technique for unambiguous structure determination and quantitation of small molecules, which has been used for decades in academic research laboratories, but only recently commercialized after the recent achievement of several groundbreaking innovations. MRR excels in structural and isomeric analysis, providing a detail of information like nuclear magnetic resonance (NMR), but at a much lower cost and faster speed, with reduced method development. Through working on a final piece of the puzzle, the development of new sampling techniques, BrightSpec seeks to unlock the full analytical potential of this powerful analytical technique to broaden its use throughout a range of applications, including metabolomics, drug discovery, natural product analysis, and the monitoring of environmental pollutants. BrightSpec has evaluated several sampling techniques for volatilization of solid samples and Laser Induced Acoustic Desorption (LIAD) was determined to be uniquely suitable for incorporation with MRR, as the sensitivity of results with these instruments can be adversely affected by the presence of solvents. BrightSpec has evaluated several sampling techniques for volatilization of solid samples and Laser Induced Acoustic Desorption (LIAD was determined to be uniquely suitable for combination with MRR, as the sensitivity of results with these instruments can be adversely affected by the presence of solvents. The project would be conducted by BrightSpec in collaboration with Kenttämaa Labs at Purdue University, which has been developing the LIAD technique for use with mass spectrometry for over 20 years and holds several LIAD-related patents. A proof-of-concept prototype LIAD-MRR instrument has been used to demonstrate the viability of coupling the two techniques. This preliminary work has de-risked this proposed Phase II project, which involves refinement of the prototype to develop a product with the necessary sensitivity, speed, and ease-of-use to facilitate commercial adoption. The resulting product will then be tested thoroughly on relevant samples in market areas where LIAD-MRR is expected to have the greatest impact. Several prospective customer use cases and samples have already been identified. Following this extensive evaluation, the product design will be refined for commercial launch at or before the end of the grant period.

Jiangsu Inc. NIH SBIR应用程序 项目摘要 分子旋转共振（MRR）光谱的新进样方法 NIH SBIR直接进入II期 Jersey，Inc. 项目摘要 本项目旨在开发一种新的分子旋转分析物采样技术， 用于固相分析物挥发的共振（MRR）光谱仪。拟议 系统，激光诱导声解吸（LIAD），将使大量的重要 化合物可以通过MRR获得，增强了我们在几个重要领域的理解， 研究和加速药物开发。由此产生的采样扩展 这种有价值的技术的范围和相应的效用将大大加快采用 重要研发领域的MRR。 MRR是一种用于明确结构测定和定量的光谱技术， 小分子，它已经在学术研究实验室使用了几十年，但只有 在最近取得了几项突破性创新之后，最近已经商业化。 MRR擅长结构和异构体分析，提供详细的信息，如核 磁共振（NMR），但在更低的成本和更快的速度，减少方法 发展通过对最后一块拼图的研究， 技术，ESPECIAL旨在释放这种强大的分析功能的全部分析潜力。 技术，以扩大其在一系列应用中使用，包括代谢组学、药物 发现、天然产物分析和环境污染物监测。 CNOSPECK评估了几种用于固体样品挥发的取样技术， 诱导声解吸（LIAD）被确定为是唯一适合于掺入 与MRR，因为这些仪器的结果的灵敏度可能会受到不利影响， 溶剂的存在。CNOSPECK评估了几种用于挥发的取样技术， 固体样品和激光诱导声解吸（LIAD）被确定为是唯一的 适合与MRR结合使用，因为这些仪器的结果灵敏度可以 受到溶剂存在的不利影响。该项目将在2010年由联合国环境规划署执行。 与普渡大学的Littämaa实验室合作，后者一直在开发LIAD 技术与质谱使用超过20年，并持有几个LIAD相关 专利 一个概念验证原型LIAD-MRR仪器已被用来证明的可行性 结合这两种技术。这项初步工作降低了拟议的第二阶段项目的风险， 这涉及改进原型以开发具有必要灵敏度的产品， 速度和易用性，以促进商业应用。然后将对最终产品进行测试 在LIAD-MRR预计最大的市场领域， 冲击已经确定了几个潜在客户使用案例和样本。 经过广泛的评估后，产品设计将在2015年12月15日进行商业发布。 或在资助期结束前。