Knee evaluation under mechanical loading by cones ultrashort echo time MR imaging

通过锥体超短回波时间 MR 成像对机械负荷下的膝关节进行评估

• 批准号: 10602431
• 负责人: saeed jerban
• 金额: $ 12.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602431
• 关键词: 3-Dimensional; Acceleration; Affect; Age; Anatomy; Body Weight; Body mass index; Bone structure; Cadaver; Cartilage; Chemicals; Clinical; Cone; Defect; Degenerative polyarthritis; Development Plans; Devices; Diagnosis; Early Diagnosis; Evaluation; Fiber; Gender; Goals; Human; Image; Imaging Techniques; Joints; Knee; Knee Osteoarthritis; Knee joint; Magic; Magnetic Resonance Imaging; Manuals; Measurement; Measures; Mechanical Stress; Mechanics; Meniscus structure of joint; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Morphology; Pain; Patients; Pattern; Phase; Physiological; Positioning Attribute; Postdoctoral Fellow; Preparation; Process; Property; Radiology Specialty; Research; Research Personnel; Rest; Scanning; Signal Transduction; Specimen; Stretching; Structure; Supine Position; Techniques; Time; Tissues; Training; United States National Institutes of Health; Variant; bone; career development; clinical imaging; design; experience; hamstring; improved; in vivo; mechanical load; mechanical properties; multidisciplinary; novel; quadriceps muscle; reconstruction; research study; substantia spongiosa; ward

ABSTRACT: Dr. Jerban is postdoctoral researcher with a multidisciplinary background who is proposing a research entitled “Knee evaluation under mechanical loading by Cones Ultrashort Echo Time MR imaging” through NIH K01 program under the mentorship of Drs. Christine Chung, Samuel Ward, and Jiang Du to develop into an independent investigator. Improving the osteoarthritis (OA) diagnosis at early stage using Magnetic Resonance Imaging (MRI) techniques are limited by three main barriers. First, the current clinical MRI techniques do not acquire signal from short T2 tissues, such as the meniscus and the deep layer of cartilage. Second, most Ultrashort Echo Time (UTE) MRI techniques that can acquire signal from short T2 tissues are orientation sensitive. Third, knee MRI is routinely performed on joints at rest, which incompletely mimics the actual physiological condition, particularly, the loading aspects. Recently, we have developed new UTE-MRI techniques (UTE-Ad-T1ρ and UTE-MT) that are not orientation-sensitive and that are designed specifically for scanning short T2 tissues of the knee. We have hypothesized that scanning knee joints during mechanical load application using these orientation-insensitive techniques will reveal the mechanical properties of the joint tissues, which in turn will help to distinguish between healthy, early stage and mild OA knee joints. We also hypothesized bone remodels in order to enhance the support to cartilage/menisci regions with defected cartilage, which complementarily confirms the early stage OA diagnosis. A research study is proposed to cover three main specific aims: dissected specimens’ study, whole knee cadaveric study, and in vivo study. First, we will accelerate the UTE-MRI techniques and then will investigate their variation patterns in healthy and moderate OA human cartilage/menisci specimens during the loading/unloading process. We will also assess the supporting bone specimens to compare with UTE variation patterns in cartilages/menisci under loading. Second, we will build and verify a pneumatic loading setup for the cadaver whole knee study, which is meant to assess the temporal variation of knees under a set of loading and unloading steps. Then the UTE-MRI variation patterns in joints from healthy, mild OA, and moderate OA groups during the loading/unloading process will be investigated. Third, we will design and build a separate loading device to perform the in vivo phase of the study. We will determine if in vivo UTE-MRI variation pattern under loading are distinct for early stage OA patients, and if UTE-MRI/CT can detect an improved bone structure and properties for early stage and mild OA knees. The feasibility of accelerating our orientation-insensitive UTE-MRI techniques and the significant sensitivity of our techniques to changes in knee tissues during mechanical load application (using an initial design of loading device) have been demonstrated in our preliminary results. Dr. Jerban and his mentors, Drs. Chung, Ward, and Du, have designed a detailed training plan and assembled a strong team of advisors to guide Dr. Jerban through his career development plan towards becoming an independent investigator.

摘要： 博士Jerban是一位具有多学科背景的博士后研究员，他提出了一项名为 通过NIH进行的“Cones超短回波时间MR成像在机械负荷下的膝关节评价” K 01项目在克莉丝汀·钟、塞缪尔·沃德和杜江博士的指导下发展成为一个 独立调查员磁共振技术在骨关节炎早期诊断中的应用 成像（MRI）技术受到三个主要障碍的限制。首先，目前的临床MRI技术不 从短T2组织获取信号，例如半月板和软骨深层。二是多数 超短回波时间（UTE）MRI技术可以从短T2组织中获取信号， 敏感第三，膝关节MRI通常是在休息时对关节进行的，这不完全模拟实际情况。 生理条件，特别是负荷方面。最近，我们开发了新的UTE-MRI技术， （UTE-Ad-T1ρ和UTE-MT），它们不是方向敏感的，并且专门设计用于扫描短 膝关节的T2组织。我们假设在施加机械载荷期间扫描膝关节 使用这些取向不敏感的技术将揭示关节组织的机械特性， 旋转将有助于区分健康、早期和轻度OA膝关节。我们还假设骨头 重塑，以增强对软骨/软骨缺损区域的支持， 补充证实了早期OA诊断。建议进行一项研究， 具体目的：解剖标本研究、全膝尸体研究和体内研究。一是加快 UTE-MRI技术，然后将研究其在健康和中度OA人群中的变化模式 在加载/卸载过程中的软骨/软骨标本。我们还要评估支撑骨 与载荷下软骨/软骨的UTE变化模式进行比较。第二，我们将建立和 验证尸体全膝关节研究的气动加载设置，这意味着评估颞 在一组加载和卸载步骤下膝盖的变化。然后，从关节中的UTE-MRI变化模式， 将研究加载/卸载过程中的健康、轻度OA和中度OA组。三是 将设计并构建单独的装载装置，以执行研究的体内阶段。我们将决定是否在 早期OA患者在负荷下的体内UTE-MRI变化模式是不同的，如果UTE-MRI/CT可以 检测早期和轻度OA膝关节骨结构和性能的改善。的可行性 加速我们的方向不敏感的UTE-MRI技术和我们的技术的显着敏感性， 在施加机械载荷（使用初始设计的载荷装置）期间膝关节组织的变化已经被 在我们的初步结果中，杰班博士和他的导师钟博士、沃德博士和杜博士设计了 一个详细的培训计划，并组建了一个强大的顾问团队，以指导杰班博士的职业生涯 成为独立调查员的发展计划。