The Role of an Effort-Reward Imbalance in Cognitive Fatigue

努力与回报失衡在认知疲劳中的作用

• 批准号: 10602469
• 负责人: Fareshte Erani
• 金额: $ 4.63万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10602469
• 关键词: Activities of Daily Living; Address; Adult; Affect; Age; Anatomy; Attention; Automobile Driving; Behavior; Behavioral; Brain; Clinical; Cognition; Cognitive; Community Healthcare; Confusion; Costs and Benefits; Data; Development; Diagnosis; Disease; Disease remission; Distress; Education; Fatigue; Functional Magnetic Resonance Imaging; Functional disorder; Goals; High Prevalence; Individual; Innovative Therapy; Intervention; Investigation; Literature; Measures; Mental Health; Methodology; Methods; Modeling; Modernization; Multiple Sclerosis; National Center for Complementary and Integrative Health; Nature; Neuroanatomy; Neurobehavioral Manifestations; Neurologic; Neuropsychology; Neurosciences; Patient Self-Report; Patients; Performance; Personal Satisfaction; Population; Prevalence; Primary Care; Process; Psyche structure; Quality of life; Rehabilitation Outcome; Relapse; Reporting; Research; Research Personnel; Rewards; Role; Scanning; Signal Transduction; Symptoms; Syndrome; Techniques; Testing; Work; aged; cognitive control; cognitive neuroscience; cognitive task; common symptom; computerized; design; disability; disabling symptom; effective therapy; experience; inclusion criteria; meetings; multiple sclerosis patient; negative affect; neuroimaging; neuropathology; novel; psychosocial; recruit; response; reward processing; sex; symptom management; white matter

PROJECT SUMMARY Fatigue is one of the most common symptoms in neurological and psychiatric syndromes. However, its nature has made it one of the most controversial and least understood phenomena despite its prevalence. The primary goal of this proposal is to test a novel theoretical approach to understanding fatigue, beginning with cognitive (mental) fatigue. Specifically, this proposal tests a model based in neuroscience and uses neuroimaging as a means to measure and understand the neurologic circuits underlying cognitive fatigue, which directly aligns with NCCIH’s objectives to advance the understanding of and support the development of novel models and methodologies to understand the neurological aspects of hard-to-manage symptoms. Background: Patients with clinical syndromes generally report the cognitive component of fatigue to be the most distressing aspect of their fatigue, affecting their ability to engage in work and making activities of daily living more difficult. Previous research has examined the influence of reward and effort separately on cognitive fatigue; however, these processes have not been integrated explicitly to test whether the interaction between effort and reward induces cognitive fatigue. To address this gap, this study aims to evaluate whether an effort- reward imbalance, a model based in cognitive neuroscience, could explain cognitive fatigue in a neurological population, namely multiple sclerosis (MS), in which cognitive fatigue is a pervasive symptom. This study will use self-report measures of fatigue, a computerized switching-task, and modern neuroimaging techniques. Notably, the switching-task manipulates both levels of cognitive control (to induce changes in effort) and reward to explain cognitive fatigue. Objectives: We hypothesize that cognitive fatigue results from a mismatch between effort and reward processing. We will test the specific hypotheses that (1) across conditions of an effort-demanding cognitive control task with different levels of reward, the effort-reward interaction will predict cognitive fatigue and (2) fronto-striatal circuit anatomical integrity and recruitment of fronto-striatal regions will be associated with the effort-reward tradeoffs and cognitive fatigue. Methods: The current study will recruit 20 right-handed individuals, 18 to 60 years old with a pre-existing diagnosis of MS (remitting-relapsing subtype) with reported complaints of cognitive fatigue, and 20 age, education, and sex-matched healthy controls meeting all inclusion criteria. In a within-subjects design, subjects will provide responses on psychosocial, neuropsychological, and subjective fatigue measures. A DTI scan and fMRI data will be collected during a computerized switching task with independent effort and reward manipulations. Implications: If cognitive fatigue results from combinations of dysfunctional cognitive control and reward processes, evidenced by both behavior and pathophysiology, we could develop a model to predict cognitive fatigue trajectory and provide a means to guide development of assessment and interventions of cognitive fatigue in MS and other syndromes.

项目摘要 疲劳是神经和精神综合征中最常见的症状之一。然而，其性质 使其成为最有争议和最不了解的现象之一，尽管它的流行。的 这项提案的主要目标是测试一种新的理论方法来理解疲劳，首先是 认知（心理）疲劳。具体来说，这项提案测试了一个基于神经科学的模型， 神经成像作为测量和理解认知疲劳的神经回路的手段， 这与NCCIH的目标直接一致，以促进对 新的模型和方法，以了解难以管理的症状的神经方面。 背景：临床综合征患者通常报告疲劳的认知成分是 最令人痛苦的方面，他们的疲劳，影响他们的能力，从事工作和日常活动， 生活更加困难。先前的研究分别考察了奖励和努力对认知的影响， 疲劳;然而，这些过程还没有被明确地整合，以测试是否之间的相互作用 努力和奖励会导致认知疲劳。为了解决这一差距，这项研究旨在评估是否努力- 奖励不平衡，一个基于认知神经科学的模型，可以解释神经系统中的认知疲劳。 在多发性硬化症（MS）患者中，认知疲劳是一种普遍症状。本研究将 使用自我报告的疲劳措施，计算机转换任务，和现代神经成像技术。 值得注意的是，转换任务操纵两个层次的认知控制（以诱导努力的变化）， 奖励来解释认知疲劳。目的：我们假设认知疲劳是由不匹配引起的， 努力和奖励之间的关系我们将测试具体的假设，（1）在一个 在不同报酬水平下的努力要求认知控制任务中，努力-报酬交互作用会预测 认知疲劳和（2）额-纹状体回路解剖完整性和额-纹状体区域的募集将 与努力-回报权衡和认知疲劳有关。方法：本研究将招募20名 惯用右手的个体，18至60岁，既往诊断为MS（缓解-复发亚型） 有认知疲劳主诉的患者和20名年龄、教育程度和性别匹配的健康对照者 符合所有入选标准。在受试者内设计中，受试者将提供有关心理社会， 神经心理学和主观疲劳测量。DTI扫描和fMRI数据将在一个 独立努力和奖励操纵的计算机化切换任务。影响：如果认知 疲劳是由功能失调的认知控制和奖励过程的组合引起的，这两个过程都证明了这一点。 行为和病理生理学，我们可以开发一个模型来预测认知疲劳轨迹，并提供一个 指导MS和其他综合征中认知疲劳的评估和干预措施的发展。

项目成果

The Relationship between Fatigue and a Clinically Accessible Measure of Switching in Individuals with Multiple Sclerosis.

多发性硬化症患者的疲劳与临床上可进行的转换测量之间的关系。

• DOI: 10.1093/arclin/acac017
• 发表时间: 2022
• 期刊: Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
• 作者: Erani,Fareshte;McKeever,Joshua;Medaglia,JohnD;Schultheis,MariaT
• 通讯作者: Schultheis,MariaT