Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults

太极拳对减缓老年人认知衰退的功效

基本信息

  • 批准号:
    10602398
  • 负责人:
  • 金额:
    $ 77.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-06-15 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Background. Exercise is generally considered a non-pharmacological strategy that plays an important protective role in preserving cognitive function or mitigating the progression of cognitive impairment for older adults with mild cognitive impairment (MCI). Most exercise interventions, however, focus exclusively on physical development. Relatively few interventions have either combined physical and cognitive training concomitantly or explicitly integrated cognitive-physical components for cognitive stimulation. Moreover, the evidence that exercise improves cognitive function in older adults with MCI is both limited and inconclusive, making it difficult to recommend best practices. Objective. The primary objective of this application is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health (TJQMMBH). TJQMMBH is built on a comprehensively researched, evidence-based program that has been shown to have multiple health outcomes but now explicitly integrates a cognitive component aimed at increasing multitasking costs and cognitive demands on performing deliberate daily motor tasks. Accordingly, grounded on our promising pilot data, our primary aim in this proposed study is to determine whether the newly developed TJQMMBH intervention will have a positive effect on cognitive function in older adults with amnestic MCI. We also have four secondary aims that will examine whether (1) TJQMMBH can slow the progression of cognitive impairment; (2) improvement in global cognitive function is mediated through gains in movement confidence; (3) the benefits of the TJQMMBH intervention on cognitive outcomes persist over a post-intervention follow-up period; and (4) there is an association between change in executive function and physical performance. Approach. Our core approach to achieving our research aims is to perform a prospective, single-blind, 3-arm, randomized (active control) trial in which the cognitively enhanced TJQMMBH intervention will be evaluated against a standard Tai Ji Quan intervention and a stretching exercise control. Our design will allow us to test the hypothesis regarding the efficacy of a 6-month TJQMMBH intervention, relative to standard Tai Ji Quan and stretching control, in improving the primary outcomes of global cognitive function and motor-cognitive dual- task gait performance and the secondary outcomes of domain-specific cognitive functions in community- dwelling older adults who have been diagnosed with amnestic MCI per established clinical criteria. Significance and impact. This work is significant because it addresses the currently limited options in community and clinical practice for offering the most effective strategies that address cognitive decline in older adults with MCI. Therefore, if the proposed intervention proves to be effective, the scientific impact is likely to be high in terms of providing an alternative, non-pharmacological-based cognitive training intervention to ameliorate cognitive decline in older Americans with MCI and delay or prevent the onset of dementia.
项目总结/摘要 背景运动通常被认为是一种非药物策略, 在保护老年人的认知功能或减缓认知障碍的进展方面具有保护作用 轻度认知障碍(MCI)。然而,大多数运动干预措施只关注 身体发育相对较少的干预措施结合了身体和认知训练 伴随地或明确地整合用于认知刺激的认知-物理组件。而且 运动改善MCI老年人认知功能的证据既有限又不确定, 因此很难推荐最佳做法。 Objective.本申请的主要目的是确定认知增强的 运动干预-太极拳:保持大脑健康(TJQMMBH)。TJQMMBH建立在 一个经过全面研究的循证计划,已被证明具有多种健康结果 但现在明确整合了认知组件,旨在增加多任务成本和认知 需要进行日常运动任务。因此,基于我们有希望的试点数据,我们的 这项拟议研究的主要目的是确定新开发的TJQMMBH干预措施是否会 对患有遗忘型MCI的老年人的认知功能有积极影响。我们还有四个二级的 目的是检查(1)TJQMMBH是否可以减缓认知障碍的进展;(2) 整体认知功能的改善是通过运动信心的增加来介导的;(3) TJQMMBH对认知结果的干预在干预后随访期内持续存在;以及(4) 执行功能的改变和身体表现之间存在关联。 Approach.我们实现研究目标的核心方法是进行一项前瞻性、单盲、3组、 将评价认知增强TJQMMBH干预的随机(活性对照)试验 对一个标准的太极拳干预和一个伸展运动控制。我们的设计可以让我们测试 关于6个月TJQMMBH干预相对于标准太极拳的有效性的假设 和伸展控制,在改善全球认知功能和运动认知双重的主要成果, 任务步态表现和社区特定领域认知功能的次要结果- 根据已建立的临床标准诊断为遗忘型MCI的居住老年人。 意义和影响。这项工作意义重大,因为它解决了目前有限的选择, 社区和临床实践,为解决老年人认知能力下降提供最有效的策略。 成人MCI因此,如果拟议的干预措施被证明是有效的,科学影响可能会 在提供替代的、非药物性的认知训练干预方面, 改善患有MCI的美国老年人的认知能力下降,延迟或预防痴呆症的发作。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial.
认知增强太极拳训练对患有轻度认知障碍或自我报告记忆问题的老年人行走期间的整体认知和双任务表现的临床效果:一项随机对照试验。
  • DOI:
    10.7326/m23-1603
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    39.2
  • 作者:
    Li,Fuzhong;Harmer,Peter;Eckstrom,Elizabeth;Fitzgerald,Kathleen;Winters-Stone,Kerri
  • 通讯作者:
    Winters-Stone,Kerri
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

FUZHONG LI其他文献

FUZHONG LI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('FUZHONG LI', 18)}}的其他基金

Dual-Task Training Exercise to Reduce Falls in Older Adults with Mild Cognitive Impairment
双任务训练可减少患有轻度认知障碍的老年人跌倒的情况
  • 批准号:
    10578178
  • 财政年份:
    2023
  • 资助金额:
    $ 77.99万
  • 项目类别:
A Remotely Delivered Tai Ji Quan Intervention to Reduce Incidence of Falls in High Risk Community-Dwelling Older Adults
远程太极拳干预可降低高危社区老年人跌倒发生率
  • 批准号:
    10628517
  • 财政年份:
    2023
  • 资助金额:
    $ 77.99万
  • 项目类别:
Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults
太极拳对减缓老年人认知衰退的功效
  • 批准号:
    10116243
  • 财政年份:
    2019
  • 资助金额:
    $ 77.99万
  • 项目类别:
Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults
太极拳对减缓老年人认知衰退的功效
  • 批准号:
    10364668
  • 财政年份:
    2019
  • 资助金额:
    $ 77.99万
  • 项目类别:
Developing an Online Tai Ji Program to Improve Health Outcomes in Older Adults
开发在线太极拳项目以改善老年人的健康状况
  • 批准号:
    10173489
  • 财政年份:
    2019
  • 资助金额:
    $ 77.99万
  • 项目类别:
Developing an Efficacious and Cost-Effective Fall Prevention Program
制定有效且具有成本效益的跌倒预防计划
  • 批准号:
    8870267
  • 财政年份:
    2014
  • 资助金额:
    $ 77.99万
  • 项目类别:
Developing an Efficacious and Cost-Effective Fall Prevention Program
制定有效且具有成本效益的跌倒预防计划
  • 批准号:
    9041475
  • 财政年份:
    2014
  • 资助金额:
    $ 77.99万
  • 项目类别:
Developing an Efficacious and Cost-Effective Fall Prevention Program
制定有效且具有成本效益的跌倒预防计划
  • 批准号:
    8696377
  • 财政年份:
    2014
  • 资助金额:
    $ 77.99万
  • 项目类别:
Translating an Effective Fall Prevention Program into a Community-Based Practice
将有效的跌倒预防计划转化为基于社区的实践
  • 批准号:
    8258061
  • 财政年份:
    2011
  • 资助金额:
    $ 77.99万
  • 项目类别:
Translating an Effective Fall Prevention Program into a Community-Based Practice
将有效的跌倒预防计划转化为基于社区的实践
  • 批准号:
    8527657
  • 财政年份:
    2011
  • 资助金额:
    $ 77.99万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 77.99万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了