Inclusion of Under-Represented Groups Core

包容代表性不足的群体核心

• 批准号: 10601065
• 负责人: CAREY E GLEASON
• 金额: $ 29.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601065
• 关键词: Address; Adult; Affect; African American; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Amyloid; Autopsy; Biological; Biological Markers; Brain; Cardiovascular Diseases; Censuses; Cerebrospinal Fluid; Clinical; Clinical Trials; Collaborations; Collection; Communities; Consultations; Data; Dementia; Diabetes Mellitus; Diet; Disease; Education; Ensure; Environment; Funding; Future; Goals; Healthcare; High Prevalence; Incidence; Individual; Institution; Insulin Resistance; Label; Left; Link; Memory; Minority Recruitment; Modeling; Native Americans; Not Hispanic or Latino; Obesity; Oneida; Participant; Population; Population Heterogeneity; Positron-Emission Tomography; Prevalence; Prevention strategy; Protocols documentation; Publications; Race; Research; Research Personnel; Risk; Role; Science; Underrepresented Populations; Variant; Weight; Wisconsin; Work; cardiovascular risk factor; clinical center; cognitive change; cohort; community engagement; data management; demographics; early onset; experience; health disparity; healthy aging; middle age; mild cognitive impairment; neural; neuroimaging; novel; outreach; participant retention; pre-clinical; preclinical study; prevent; programs; racial population; racism; recruit; success; tau Proteins; theories; treatment strategy; vascular risk factor

PROJECT SUMMARY - INCLUSION OF UNDERREPRESENTED GROUPS CORE (CORE F) The Inclusion of Underrepresented Groups (URG) Core currently works with the Clinical; Outreach, Recruitment, and Engagement (ORE); Data Management and Statistical; and Biomarker Cores to identify and resolve the barriers to research participation for African and Native Americans. In this third round of Wisconsin Alzheimer's Disease Research Center (ADRC) funding, the URG Core will continue to be fully integrated with the Center, assisting investigators to engage Native and African American communities, ensuring adequate inclusion to answer scientific questions and optimize generalizability of findings. The URG Core's effort will include recruitment of middle-aged URG participants. Ages 45 to 65, this cohort is known as our IMPACT participants (Investigating Memory in Preclinical AD-Causes and Treatment). The URG Core will also emphasize retention of existing URG participants and replenishment of URG participants who have left the Clinical Core. Toward this, we will accomplish the following Specific Aims: Aim 1: Working with the ORE and Clinical Cores, the URG Core will promote recruitment, retention, and replenishment of participants from URG into the Clinical Core so that URG membership continues to represent more than 20% of the overall Clinical Core membership. Sub-Aim 1a: Through collaborations with the African American community, the URG core will promote recruitment, retention and replenishment of African American participants into the Clinical Core. Sub-Aim 1b: Through collaborations with the Native American community, the URG core will promote recruitment, retention and replenishment of Native American participants into the Clinical Core. Aim 2: In concert with the Biomarkers Core, the URG Core will promote recruitment and retention of participants from URG into biomarkers studies, including the collection of cerebrospinal fluid, amyloid and tau PET imaging, and other novel neuroimaging and biomarker studies. Aim 3: URG Core will provide consultation and support for approved Center-affiliated studies seeking to recruit and retain research participants from URGs into research protocols, clinical trials. and autopsy. Recent publications suggest that African and Native Americans demonstrate the highest prevalence and incidence of both early-onset and late-onset cases of AD and related dementias. As a result, it is imperative to develop AD treatment and prevention strategies effective for a heterogeneous US population, especially those segments most affected by AD and related disorders. The URG Core's role is to ensure adequate inclusion of URG into the Clinical Core and Wisconsin ADRC-affiliated studies so that AD-related health disparities are fully addressed. Our past and future successes are founded on a model of programmatic community engagement.

项目摘要 - 包括代表性不足的群体核心（核心F） 当前，包括代表性不足的群体（URG）核心包括临床合作；外展，招聘， 和参与（矿石）；数据管理和统计；和生物标志物核心以识别和解决 非洲和美洲原住民研究参与的障碍。在威斯康星州阿尔茨海默氏症的第三轮中 疾病研究中心（ADRC）资金，URG核心将继续与该中心完全融合 协助调查人员参与原住民和非裔美国人社区，以确保足够的包容性 回答科学问题并优化发现的普遍性。 URG核心的努力将包括 招募中年URG参与者。年龄在45至65岁时，该队列被称为我们的影响参与者 （研究临床前广告原因和治疗中的记忆）。 URG核心还将强调保留 现有的URG参与者以及离开临床核心的URG参与者的补充。对此， 我们将完成以下具体目标： AIM 1：使用矿石和临床核心，URG核心将促进招募，保留和 将参与者从URG补充到临床核心，以使URG成员继续 占整体临床核心成员资格的20％以上。 Sub-aim 1A：通过与非裔美国人社区的合作，URG核心将促进 非裔美国人参与者招募，保留和补充为临床核心。 Sub-aim 1B：通过与美国原住民社区的合作，URG核心将促进 美国原住民参与者招募，保留和补充为临床核心。 AIM 2：与生物标志物核心一致，URG核心将促进参与者的招聘和保留 从URG到生物标志物研究，包括脑脊液的收集，淀粉样蛋白和Tau PET 成像以及其他新型的神经影像学和生物标志物研究。 AIM 3：URG Core将为寻求招募的批准的中心附属研究提供咨询和支持 并将URG的研究参与者保留到研究方案中，临床试验。和尸检。 最近的出版物表明，非洲和美洲原住民的患病率最高， AD和相关痴呆症的早期发病和晚期发病率的发生率。结果，必须 制定广告治疗和预防策略对美国的异质人群有效，尤其是那些人群 受AD和相关疾病影响最大的细分市场。 URG核心的作用是确保足够的包含 将URG进入临床核心和威斯康星州ADRC相关研究，以使广告相关的健康差异完全 解决。我们的过去和未来成功建立在程序化社区参与模型上。