Inclusion of Under-Represented Groups Core

包容代表性不足的群体核心

• 批准号: 10601065
• 负责人: CAREY E GLEASON
• 金额: $ 29.57万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601065
• 关键词: Address; Adult; Affect; African American; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Amyloid; Autopsy; Biological; Biological Markers; Brain; Cardiovascular Diseases; Censuses; Cerebrospinal Fluid; Clinical; Clinical Trials; Collaborations; Collection; Communities; Consultations; Data; Dementia; Diabetes Mellitus; Diet; Disease; Education; Ensure; Environment; Funding; Future; Goals; Healthcare; High Prevalence; Incidence; Individual; Institution; Insulin Resistance; Label; Left; Link; Memory; Minority Recruitment; Modeling; Native Americans; Not Hispanic or Latino; Obesity; Oneida; Participant; Population; Population Heterogeneity; Positron-Emission Tomography; Prevalence; Prevention strategy; Protocols documentation; Publications; Race; Research; Research Personnel; Risk; Role; Science; Underrepresented Populations; Variant; Weight; Wisconsin; Work; cardiovascular risk factor; clinical center; cognitive change; cohort; community engagement; data management; demographics; early onset; experience; health disparity; healthy aging; middle age; mild cognitive impairment; neural; neuroimaging; novel; outreach; participant retention; pre-clinical; preclinical study; prevent; programs; racial population; racism; recruit; success; tau Proteins; theories; treatment strategy; vascular risk factor

PROJECT SUMMARY - INCLUSION OF UNDERREPRESENTED GROUPS CORE (CORE F) The Inclusion of Underrepresented Groups (URG) Core currently works with the Clinical; Outreach, Recruitment, and Engagement (ORE); Data Management and Statistical; and Biomarker Cores to identify and resolve the barriers to research participation for African and Native Americans. In this third round of Wisconsin Alzheimer's Disease Research Center (ADRC) funding, the URG Core will continue to be fully integrated with the Center, assisting investigators to engage Native and African American communities, ensuring adequate inclusion to answer scientific questions and optimize generalizability of findings. The URG Core's effort will include recruitment of middle-aged URG participants. Ages 45 to 65, this cohort is known as our IMPACT participants (Investigating Memory in Preclinical AD-Causes and Treatment). The URG Core will also emphasize retention of existing URG participants and replenishment of URG participants who have left the Clinical Core. Toward this, we will accomplish the following Specific Aims: Aim 1: Working with the ORE and Clinical Cores, the URG Core will promote recruitment, retention, and replenishment of participants from URG into the Clinical Core so that URG membership continues to represent more than 20% of the overall Clinical Core membership. Sub-Aim 1a: Through collaborations with the African American community, the URG core will promote recruitment, retention and replenishment of African American participants into the Clinical Core. Sub-Aim 1b: Through collaborations with the Native American community, the URG core will promote recruitment, retention and replenishment of Native American participants into the Clinical Core. Aim 2: In concert with the Biomarkers Core, the URG Core will promote recruitment and retention of participants from URG into biomarkers studies, including the collection of cerebrospinal fluid, amyloid and tau PET imaging, and other novel neuroimaging and biomarker studies. Aim 3: URG Core will provide consultation and support for approved Center-affiliated studies seeking to recruit and retain research participants from URGs into research protocols, clinical trials. and autopsy. Recent publications suggest that African and Native Americans demonstrate the highest prevalence and incidence of both early-onset and late-onset cases of AD and related dementias. As a result, it is imperative to develop AD treatment and prevention strategies effective for a heterogeneous US population, especially those segments most affected by AD and related disorders. The URG Core's role is to ensure adequate inclusion of URG into the Clinical Core and Wisconsin ADRC-affiliated studies so that AD-related health disparities are fully addressed. Our past and future successes are founded on a model of programmatic community engagement.

项目摘要 - 纳入弱势群体核心（核心 F） 纳入代表性不足群体 (URG) 核心目前与临床合作；外展、招聘、 和参与度（ORE）；数据管理与统计；和生物标记核心来识别和解决 非洲人和美洲原住民参与研究的障碍。在威斯康星州阿尔茨海默病第三轮中 在疾病研究中心 (ADRC) 的资助下，URG 核心将继续与该中心完全整合， 协助调查人员与原住民和非裔美国人社区接触，确保充分包容 回答科学问题并优化研究结果的普遍性。 URG 核心的努力将包括 招募中年URG参与者。该群体年龄在 45 至 65 岁之间，被称为我们的 IMPACT 参与者 （研究临床前 AD 原因和治疗中的记忆）。 URG 核心还将强调保留 现有 URG 参与者以及补充已离开临床核心的 URG 参与者。对此， 我们将实现以下具体目标： 目标 1：URG 核心与 ORE 和临床核心合作，促进招募、保留和 将参与者从 URG 补充到临床核心，以便 URG 会员资格继续 占临床核心会员总数的 20% 以上。 子目标 1a：通过与非裔美国人社区的合作，URG 核心将促进 招募、保留和补充非裔美国参与者进入临床核心。 子目标 1b：通过与美洲原住民社区合作，URG 核心将促进 招募、保留和补充美国原住民参与者进入临床核心。 目标 2：URG 核心与 Biomarkers Core 合作，促进参与者的招募和保留 从 URG 进入生物标志物研究，包括收集脑脊液、淀粉样蛋白和 tau PET 成像，以及其他新颖的神经影像和生物标志物研究。 目标 3：URG 核心将为已批准的寻求招募的中心附属研究提供咨询和支持 并保留来自 URG 的研究参与者进入研究方案、临床试验。和尸检。 最近的出版物表明，非洲人和美洲原住民的患病率最高， 早发性和迟发性 AD 及相关痴呆病例的发病率。因此，当务之急是 制定对美国不同人群有效的 AD 治疗和预防策略，尤其是那些 受 AD 和相关疾病影响最严重的部分。 URG 核心的作用是确保充分包容 URG 纳入临床核心和威斯康星州 ADRC 附属研究，以便充分消除 AD 相关的健康差异 已解决。我们过去和未来的成功都建立在程序化社区参与的模型之上。