Inclusion of Under-Represented Groups Core

项目摘要-列入代表性不足的群体核心（核心F） 纳入代表性不足的群体（URG）核心目前与临床;外联，招聘， 和参与（ORE）;数据管理和统计;以及生物标志物核心，以识别和解决 阻碍非洲人和美洲原住民参与研究的障碍。在威斯康星州老年痴呆症的第三轮 疾病研究中心（ADRC）的资金，URG核心将继续与该中心完全整合， 协助调查人员与原住民和非裔美国人社区接触，确保充分包容， 回答科学问题，优化研究结果的普遍性。URG核心的工作将包括 招聘中年URG参与者。年龄在45到65岁之间，这一组被称为我们的IMPACT参与者 （研究临床前AD的记忆-原因和治疗）。URG核心还将强调保留 现有的URG参与者和补充已离开临床中心的URG参与者。为此， 我们将实现以下具体目标： 目标1：与ORE和临床核心合作，URG核心将促进招聘，保留， 将URG的参与者补充到临床核心，以便URG成员继续 占临床核心成员总数的20%以上。 次级目标1a：通过与非裔美国人社区合作，城市资源小组核心将促进 招募、保留和补充非裔美国人参与者进入临床核心。 子目标1b：通过与美洲原住民社区的合作，URG核心将促进 招募、保留和补充美洲原住民参与者进入临床核心。 目标2：与生物标志物核心一致，URG核心将促进参与者的招募和保留 从URG到生物标志物研究，包括收集脑脊液、淀粉样蛋白和tau PET 成像和其他新的神经成像和生物标志物研究。 目标3：URG核心将为寻求招募的获批中心附属研究提供咨询和支持 并将URG的研究参与者保留在研究方案和临床试验中。还有尸检 最近的出版物表明，非洲人和美洲原住民的患病率最高， 早发和晚发AD及相关痴呆病例的发病率。因此，必须 制定对美国异质人群有效的AD治疗和预防策略，特别是那些 受AD和相关疾病影响最大的部分。URG核心的作用是确保充分纳入 将URG纳入临床核心研究和威斯康星州ADRC附属研究，以便充分了解与AD相关的健康差异。 处理。我们过去和未来的成功都建立在计划性社区参与的模式之上。

PROJECT SUMMARY - INCLUSION OF UNDERREPRESENTED GROUPS CORE (CORE F) The Inclusion of Underrepresented Groups (URG) Core currently works with the Clinical; Outreach, Recruitment, and Engagement (ORE); Data Management and Statistical; and Biomarker Cores to identify and resolve the barriers to research participation for African and Native Americans. In this third round of Wisconsin Alzheimer's Disease Research Center (ADRC) funding, the URG Core will continue to be fully integrated with the Center, assisting investigators to engage Native and African American communities, ensuring adequate inclusion to answer scientific questions and optimize generalizability of findings. The URG Core's effort will include recruitment of middle-aged URG participants. Ages 45 to 65, this cohort is known as our IMPACT participants (Investigating Memory in Preclinical AD-Causes and Treatment). The URG Core will also emphasize retention of existing URG participants and replenishment of URG participants who have left the Clinical Core. Toward this, we will accomplish the following Specific Aims: Aim 1: Working with the ORE and Clinical Cores, the URG Core will promote recruitment, retention, and replenishment of participants from URG into the Clinical Core so that URG membership continues to represent more than 20% of the overall Clinical Core membership. Sub-Aim 1a: Through collaborations with the African American community, the URG core will promote recruitment, retention and replenishment of African American participants into the Clinical Core. Sub-Aim 1b: Through collaborations with the Native American community, the URG core will promote recruitment, retention and replenishment of Native American participants into the Clinical Core. Aim 2: In concert with the Biomarkers Core, the URG Core will promote recruitment and retention of participants from URG into biomarkers studies, including the collection of cerebrospinal fluid, amyloid and tau PET imaging, and other novel neuroimaging and biomarker studies. Aim 3: URG Core will provide consultation and support for approved Center-affiliated studies seeking to recruit and retain research participants from URGs into research protocols, clinical trials. and autopsy. Recent publications suggest that African and Native Americans demonstrate the highest prevalence and incidence of both early-onset and late-onset cases of AD and related dementias. As a result, it is imperative to develop AD treatment and prevention strategies effective for a heterogeneous US population, especially those segments most affected by AD and related disorders. The URG Core's role is to ensure adequate inclusion of URG into the Clinical Core and Wisconsin ADRC-affiliated studies so that AD-related health disparities are fully addressed. Our past and future successes are founded on a model of programmatic community engagement.