Latent profiles of prenatal exposure to toxic metals and psychosocial risk and protective factors: testing associations with child developmental outcomes and moderations by caregiving experience

产前接触有毒金属和心理社会风险和保护因素的潜在特征：测试与儿童发育结果的关联以及护理经验的调节

• 批准号: 10606183
• 负责人: Amanda C. Wylie
• 金额: $ 4.17万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606183
• 关键词: Achievement; Address; Age; Age Months; Arsenic; Behavior; Brain; Buffers; Cadmium; Categories; Chemicals; Child; Child Development; Cognitive; Data; Decision Making; Dedications; Development; Diet; Discipline; Disparity; Emotional; Ensure; Environmental Exposure; Environmental Science; Equilibrium; Exposure to; Fetal Development; Foundations; Future; Goals; Health Sciences; Individual; Infant Development; Intervention; Joints; Language; Lead; Life; Longitudinal Studies; Measures; Mentorship; Modeling; Mothers; National Institute of Environmental Health Sciences; Outcome; Perinatal; Physical environment; Population; Predictive Factor; Psychological Stress; Psychology; Public Health; Research; Risk; Risk Factors; Science; Social Environment; Social support; Testing; Toxic effect; Training; career development; caregiving; early childhood; early experience; executive function; experience; falls; indexing; interdisciplinary collaboration; multidimensional data; neurodevelopment; person centered; prenatal; prenatal exposure; programs; protective factors; psychologic; psychological stressor; psychosocial; skill acquisition; skills; social; social factors; social stress; social stressor; stressor; toxic metal; toxicant

PROJECT SUMMARY Exposures to toxic metals and psychological and social stressors during sensitive periods of fetal and infant development are associated with poorer child cognitive and socioemotional development. There is also evidence for moderating effects between toxic metals and psychological and social stressors, such that the effects of toxic metals on development may be conditional upon exposures to psychological and social stress and vice versa. Because physical, psychological, and social risk factors tend to cluster, the study of combined exposures may be more ecologically valid. Though prior studies have utilized two-way statistical interactions to examine these combined effects, these models still fall short in recognizing that individuals are concurrently exposed to multiple risk and protective factors across the physical and social environments. Previous studies have also failed to rigorously test the extent to which caregiving experience may mitigate or exacerbate the effects of prenatal exposure to toxic metals on child outcomes. Using longitudinal data from the Brain and Early Experiences Study and a finite mixture modeling approach, this study will: 1) categorize prenatal exposures to toxic metals, psychological and social risk factors, and protective factors into latent profiles of prenatal risk; 2) test associations between latent profiles of prenatal risk and indices of child cognitive and socioemotional development at 36 months old; and 3) examine indices of caregiving experience as moderators for the effects of latent profiles of prenatal risk on child cognitive and socioemotional development. Throughout these analyses, inferences between the latent profile approach and more traditional statistical approaches (i.e., two-way interactions) will be compared. This study will examine prenatal toxic metal and psychological and social risk holistically and has the potential to identify strategies to offset the effects of prenatal toxic metals and psychological and social risk on child development. The accompanying training plan will provide Ms. Wylie with the foundation to build her program of research which will combine developmental and public health sciences to study the joint influences of the physical and social environments on child development, and how positive social experience may be used to mitigate the effects of physical and chemical stressors. Specifically, Ms. Wylie will a) build her substantive expertise in early life environmental exposures relevant to child neurodevelopment and their mechanisms of action; b) expand her quantitative skillset towards the application of finite mixture models and moderation analyses; c) expand her expertise in the study of protective social environments in early life; and d) develop her interdisciplinary collaborations and career development skills. Ms. Wylie has assembled a stellar and cohesive mentorship team from the disciplines of developmental science, environmental science, and quantitative psychology. This mentorship team carries the expertise, experience, and dedication to Ms. Wylie’s professional development that will ensure the successful completion of her training goals and research plan.

项目概要 胎儿和婴儿敏感期接触有毒金属以及心理和社会压力源 发展与儿童认知和社会情感发展较差有关。还有证据 用于调节有毒金属与心理和社会压力源之间的影响，从而使有毒金属的影响 金属对发育的影响可能取决于心理和社会压力，反之亦然。 由于身体、心理和社会风险因素往往会聚集，因此对组合暴露的研究可能会 更具生态有效性。尽管之前的研究已经利用双向统计交互来检验这些 综合影响，这些模型仍然未能认识到个体同时暴露于多种 物理和社会环境中的风险和保护因素。之前的研究也未能 严格测试护理经验可能减轻或加剧产前影响的程度 接触有毒金属对儿童结局的影响。使用大脑和早期经历研究的纵向数据 和有限混合建模方法，本研究将：1）对有毒金属的产前暴露进行分类， 心理和社会风险因素以及潜在产前风险的保护因素； 2) 测试关联 产前风险的潜在特征与 36 岁时儿童认知和社会情感发展指数之间的关系 几个月大； 3）检查护理经验指数作为潜在特征影响的调节因素 儿童认知和社会情感发展的产前风险。通过这些分析、推论 潜在轮廓方法和更传统的统计方法（即双向交互）之间的差异将 进行比较。这项研究将全面检查产前有毒金属以及心理和社会风险，并已 确定抵消产前有毒金属影响以及心理和社会风险的策略的潜力 关于儿童发展。随附的培训计划将为 Wylie 女士提供建立她的基础 研究计划将结合发展科学和公共卫生科学来研究共同影响 物理和社会环境对儿童发展的影响，以及如何利用积极的社会经验 减轻物理和化学压力源的影响。具体来说，怀利女士将 a) 建立她的实质性 与儿童神经发育及其机制相关的早期生命环境暴露方面的专业知识 行动; b) 将她的定量技能扩展到有限混合模型和调节的应用 分析； c) 扩大她在早期生活保护性社会环境研究方面的专业知识； d) 培养她 跨学科合作和职业发展技能。 Wylie 女士组建了一支出色且有凝聚力的团队 来自发展科学、环境科学和定量学科的导师团队 心理学。这个导师团队拥有 Wylie 女士专业知识、经验和奉献精神 的发展将确保她的培训目标和研究计划的成功完成。