2023 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

摘要 这项提议寻求对戈登研究会议(GRC)关于肌肉兴奋的部分支持- 收缩偶联(ECC)。这是关于这一重要议题的唯一一次重大国家/国际会议。为 我们将深入研究心脏、骨骼和平滑肌的正常生理功能、疾病中的功能障碍和 从分子生物物理学、电和钙依赖信号到 集成功能。GRC将于2023年6月4日至9日在新罕布夏州的科比-索耶学院举行会议。这个 该计划是在与ECC研究领域的广泛咨询小组协商后制定的。本集团和 GRC由Donald M Bers博士(美国)和Ana Gómez博士(法国)担任主席。还寻求支持，以 联合戈登研究研讨会(GRS)，由早期调查人员(ESIS； 学生、博士后和新教师)。GRS紧接GRC之前，由两个ESIS担任主席 (米歇尔·门罗在新西兰，弗朗西斯科·阿尔瓦拉多在美国)。的两个首要目标 GRC和GRS将：1)聚集顶尖科学家演讲者和参与者，分享新的突破， 激发和参与从分子机制到集成的深入和广泛的讨论 心肌、骨骼肌和平滑肌的生理学和病理生理学；2)增加能见度和 通过提供互动的非正式会议，领导初级ECC专家并激励/激励他们的研究事业 在论坛上展示他们的工作和网络。2023年ECC GRC将有~37名演讲者，~6场较短的演讲 突出精选的海报摘要和~18个主题讨论领袖。科学会议将详细说明 ECC的结构-功能在多个尺度上，从分子水平到翻译成新的治疗方法 与ECC相关的战略。包括：1)L型钙通道；2)Ryanodine受体；3)IP3受体 和核信号，4)恶性高热和CPVT-心律失常，5)储存操作的钙内流，Trp 和伸展激活的通道，6)肌营养不良和糖尿病，8)心力衰竭和骨骼肌 疲惫。心肌、骨骼肌和平滑肌将一起讨论，以突出相似和不同 在分子和肌肉水平上加强对健康和疾病中每种肌肉类型的了解。《全球资源报告》 将帮助Esis培养自信和社区意识，这将鼓励他们充分参与 在GRC期间与高级同事进行正式和非正式讨论。GRC将重点介绍ESI演示文稿 以几种方式(简短的演讲、海报闪电演讲和讨论联合领导人)增加对这些 初级调查人员和他们的新研究。我们预计将吸引约175名基础和临床研究人员 职业阶段、性别、种族、遗产、研究学科、机构和地理位置。我们的目标是 促进：1)开放的对话和沟通，2)EIS的知名度和职业发展，3)实质性 关于肌肉如何正常运作、疾病中出了什么问题以及什么是新奇的新知识 治疗策略可能会使那些受到多种疾病困扰的人受益。

ABSTRACT This proposal seeks partial support for the Gordon Research Conference (GRC) on Muscle Excitation- Contraction coupling (ECC). This is the only major national/international meeting on this important topic. For cardiac, skeletal and smooth muscle we will delve into normal physiological function, dysfunction in disease and potential therapeutics at levels from molecular biophysics, electrical and calcium-dependent signaling to integrated function. This GRC will meet June 4-9, 2023 at Colby-Sawyer College in New Hampshire. The program was developed in consultation with a broad advisory group of leaders in ECC research. This Group and the GRC are chaired by Drs. Donald M Bers (USA) and Ana Gómez (France). Support is also sought for an associated Gordon Research Seminar (GRS) that is led by and focused upon early stage investigators (ESIs; students, postdocs and new faculty). This GRS immediately precedes the GRC and is chaired by two ESIs (Michelle Munro in New Zealand, and Francisco Alvarado in the USA). The two overarching objectives of the GRC and GRS are to: 1) Assemble top-notch scientist-speakers and participants to share new breakthroughs, stimulate and participate in deep and broad discussions that span from molecular mechanisms to integrated physiology and pathophysiology in cardiac, skeletal and smooth muscle, and 2) Increase the visibility and leadership of junior ECC ESIs and inspire/motivate their research careers by providing an interactive informal forum in which to present their work and network. The 2023 ECC GRC will have ~37 speakers, ~6 shorter talks to highlight selected poster abstracts and ~18 topic discussion leaders. Scientific sessions will detail the structure-function of ECC at multiple scales ranging, from molecular level to the translation into new therapeutic strategies for ECC-related. Sessions include, 1) L-type Ca Channels, 2) Ryanodine Receptors, 3) IP3 Receptors and Nuclear Signaling, 4) Malignant Hyperthermia and CPVT-Arrhythmias, 5) Store-Operated Ca entry, TRP and stretch-activated channels, 6) Muscular Dystrophy and Diabetes, and 8) Heart Failure and Skeletal Muscle Fatigue. Cardiac, skeletal and smooth muscle will be discussed together to highlight similarities and differences to enhance understanding of each muscle type at molecular and muscle levels in health and disease. The GRS will help ESIs develop self-confidence and sense of community that will encourage their full engagement in formal and informal discussion with senior colleagues during the GRC. The GRC will highlight ESI presentations in several ways (short talks, Poster Flash talks and discussion co-leaders) that heighten the exposure of these junior investigators and their novel research. We expect to attract ~175 basic and clinical researchers across career stages, genders, races, heritages, research disciplines, institutions, and geographical locations. We aim to promote: 1) open dialogue and communication, 2) visibility and career development for ESIs, 3) substantial new and deep knowledge about how muscle functions normally, what goes wrong in disease and what novel therapeutic strategies may benefit those afflicted by numerous diseases.