Asian American Community Cohort of the New York Metropolitan Area

纽约都会区亚裔美国人社区群体

• 批准号: 10724342
• 负责人: Jiyoung Ahn
• 金额: $ 63.22万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724342
• 关键词: Address; Adult; Age; American; Area; Asian Americans; Atherosclerosis; Behavioral; Biological; Biological Markers; Blood; Blood Vessels; Cardiometabolic Disease; Cardiovascular Diseases; Chinese; Chinese American; Clinical; Collaborations; Collection; Communities; Community Outreach; Community Participation; Data; Development; Disease; Disparity; Endothelium; Enrollment; Environment; Environmental Risk Factor; Epidemiology; Ethnic Population; Event; Extramural Activities; Funding; Genetic; Genomics; Goals; Grant; Health; Home; Institution; Knowledge; Korean American; Koreans; Life Style; Limited English Proficiency; Low income; Measures; Medical Research; Metabolic Diseases; Morbidity - disease rate; Names; Native Hawaiian or Other Pacific Islander; New York; Non-Insulin-Dependent Diabetes Mellitus; Oral; Outcome; Participant; Patient Recruitments; Persons; Population; Questionnaires; Recruitment Activity; Research; Research Infrastructure; Retina; Science; Specialized Program of Research Excellence; Surveys; United States National Institutes of Health; Urine; Work; biobank; cancer health disparity; cardiovascular health; clinical examination; clinically significant; cohort; community based participatory research; data harmonization; data sharing; diet and exercise; epidemiology study; experience; follow-up; health disparity; innovation; marginalization; metropolitan; microbiome; microbiome research; mortality; population health; programs; racial population; recruit; research study; social culture; social disparities; sociocultural determinant; stool sample; urban area

ABSTRACT Asian Americans (AsA) are the fastest growing racial/ethnic group in the US, projected to double to 43 million people by 2050; however, our understanding of the factors that lead to disease or health in AsA is limited because AsA overall and specific AsA subpopulations have been severely under-represented in medical research. To address key population health research gaps, the NIH has called for a new epidemiologic cohort among AsA and Native Hawaiian/Pacific Islanders (NHPI). We propose to serve in this nation-wide initiative as a Clinical/Community Field Center for AsA in the New York Metropolitan Area. The overarching rationale for a national Asian American Community Cohort (here named the AACC) is to examine from a “populomics” perspective, the biological, lifestyle, behavioral/environmental and sociocultural factors that impact the health of AsA, with the ultimate goal of reducing morbidity and mortality. In the NY area, the AACC-NY will enroll Korean American adults—the most understudied AsA group—and Chinese American adults—the largest AsA group. A strong feature of AACC-NY is our capacity to target often-marginalized, low- income, non-English speaking communities in the NY area, who most often experience social and health disparities and who are often under-represented in epidemiologic research. The New York Metropolitan Area is home to the largest and most diverse AsA population of any urban region in the US, comprising 3.2 million residents, of which ~40% are Korean or Chinese American. In the longer term, CVD and other metabolic diseases such as type II diabetes will be our priority; however, the cohort also supports aims related to broad health outcomes, particularly through collaborations within the overall national cohort framework. In this funding period, leveraging our exceptionally strong community outreach, engagement, and community based participatory research programs with AsA communities, in Aim 1 we will enroll a cohort of 3200 AsA (age 25–64 years, including 1600 Korean and 1600 Chinese) and conduct participant follow up and surveillance activities, including ascertainment of events of clinical significance. In Aim 2 we will complete baseline exam, including questionnaire survey, physical exam, subclinical measure of CVD, and biospecimen collection. In Aim 3, we will complete data harmonization and sharing with Other Clinical/Community Field and Coordinating Centers. Aim 4 will focus on short-term research studies to examine the effect of sociocultural, diet/exercise, environment, and biological (genetics, microbiome) factors in relation to subclinical markers for cardiometabolic disease in overall and Korean and Chinese ethnic subgroups. The AACC is a unique urban platform with integrated community participation to address priority knowledge gaps regarding cardiovascular health and its disparities in specific AsA subpopulations. This research will provide the scientific basis for addressing these challenges in AsA communities, including the often marginalized and underserved.

抽象的 亚裔美国人（ASA）是美国增长最快的种族/族裔，预计将翻一番，达到4300万 到2050年的人；但是，我们对导致ASA疾病或健康因素的理解有限，因为 在医学研究中，ASA总体和特定的ASA亚群的代表性严重不足。到 解决主要人口健康研究差距，NIH呼吁在ASA之间建立新的流行病学队列 和夏威夷人/太平洋岛民（NHPI）。我们建议在这项全国性的倡议中担任 纽约大都会地区ASA的临床/社区现场中心。 国民亚裔美国人社区队列的总体原理（这里为AACC）是 从“民众学”的角度检查生物学，生活方式，行为/环境和社会文化 影响ASA健康的因素，其最终目标是降低发病率和死亡率。在纽约地区， AACC-NY将招募韩裔美国成年人（最了解的ASA群体）和华裔美国人 成人 - 最大的ASA组。 AACC-NY的一个强大特征是我们靶向经常划分的，低 - 收入，纽约地区的非英语社区，他们经常体验社会和健康 在流行病学研究中的差异和常常代表性不足。纽约大都市地区是 美国所有城市地区最大，最潜水员的ASA人口的所在地，完成了320万 居民，其中约40％是韩国或华裔美国人。从长远来看，CVD和其他代谢 诸如II型糖尿病之类的疾病将是我们的优先事项；但是，该队列还支持与广泛有关的目标 健康成果，特别是通过在整个国家队列框架内的合作。 在这个资金期间，利用我们非常强大的社区宣传，参与和社区 基于ASA社区的基于参与研究计划，在AIM 1中，我们将注册3200 ASA的队列（年龄 25 - 64年，包括1600韩语和1600个中文），并进行参与者跟进和监视 活动，包括确定临床意义的事件。在AIM 2中，我们将完成基线考试， 包括问卷调查，体格检查，CVD的亚临床测量以及生物循环收集。目标 3，我们将完成数据协调并与其他临床/社区领域共享并协调 中心。 AIM 4将专注于短期研究，以检查社会文化，饮食/运动的影响， 环境和生物学（遗传学，微生物组）与心脏代谢的亚临床标记有关的因素 整体和韩国和中国种族亚组的疾病。 AACC是一个独特的城市平台，具有集成的社区参与，以解决优先知识差距 关于心血管健康及其在特定ASA亚群中的差异。这项研究将提供 在ASA社区中解决这些挑战的科学依据，包括经常被边缘化的和 服务不足。