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Malaria Evolution in South Asia

南亚的疟疾演变

基本信息

批准号：
10606608
负责人：
PRADIPSINH K. RATHOD
金额：
$ 134.56万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10606608
关键词：
Africa Architecture Artemisinins Asia Back Basic Science Cells Cessation of life Characteristics Chloroquine Choking Clinical Markers Clinical Research Collection Communities Community Surveys Complex Country Culicidae Disease Disease model Dissection Drug resistance Drug usage Evolution Failure Family Far East Funding Genomics Government Grant Health Hospitals Human Immunity India Indigenous Infection Infrastructure Invaded Investments Laboratory Research Laboratory Study Latin America Learning Link Malaria Medical Research Modernization Molecular Morbidity - disease rate Mutagenesis Nature Parasites Pathogenesis Pathology Pathway interactions Pattern Persons Pharmaceutical Preparations Pharmacoepidemiology Phenotype Plasmodium falciparum Plasmodium vivax Positioning Attribute Poverty Public Health Research Resistance Resources Rest Role Running Scientist Severity of illness Shapes Site Southeastern Asia Training Travel United States National Institutes of Health Urban Community Variant Visit Work empowerment experimental study feeding human disease implementation science interest international center malaria transmission medical schools molecular marker molecular phenotype mortality novel parasite genome programs response success trait transmission process urban area vector vector mosquito welfare

项目摘要

Malaria is a devastating human disease, especially amongst the most vulnerable sub-populations of the world. It is important to understand how malaria parasites will respond to global elimination efforts. The emergence of drug resistance, dissemination of these traits to broader localities, and evolution of parasites into forms that may lead to greater pathology are of particular interest. The dominant human malaria parasite, P. falciparum, has been studied in Africa and SE Asia, but much remains to be learned about its patterns in South Asia. The other major human malaria parasite, P. vivax, continues to cause morbidity and mortality. However, phenotypic dissection of P. vivax traits and formal demonstration of variations between P. vivax isolates is restricted by our limited ability to culture them. In this renewal application, we will study: (1) the extent to which drug use and drug resistance shape the evolution of malaria parasites in India, (2) the extent to which vector distribution and characteristics effect transmission of drug resistance traits, and (3) how parasites’ response to immunity triggers novel interactions with host cells and leads to severe disease. India has both P. falciparum and P. vivax, has ecological conditions that are different and relevant, and may act as a bridge between SE Asia and eastern coast of E Africa. The MESA team partners will study malaria parasites in human hosts, mosquito vectors, and controlled laboratory studies after adaptation. Over the last five years, the team has successfully developed new clinical study sites in urban areas and community survey capabilities in remote, isolated parts of India. Our ability to work closely and collaboratively with government and non-governmental entities in India and provide professional opportunities for young, local scientists greatly facilitate our work. Key findings on evolution of drug resistance in malaria parasites, their interactions with mosquitoes, and ability to cause severe disease will be further pursed in this competitive renewal.

疟疾是一种毁灭性的人类疾病，特别是在最脆弱的亚群体中

项目成果

期刊论文数量（57）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Severe malaria is associated with parasite binding to endothelial protein C receptor.

DOI：
10.1038/nature12216
发表时间：
2013-06-27
期刊：
Nature
影响因子：
64.8
作者：
通讯作者：

Indispensable malaria genes.

不可或缺的疟疾基因。

DOI：
10.1126/science.aat5092
发表时间：
2018
期刊：
Science (New York, N.Y.)
影响因子：
0
作者：
White,John;Rathod,PradipsinhK
通讯作者：
Rathod,PradipsinhK

Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum.

Tartrolon E 是一种海洋共生细菌的次级代谢产物，是无性和有性恶性疟原虫的有效抑制剂。

DOI：
10.1128/aac.00684-23
发表时间：
2024
期刊：
Antimicrobial agents and chemotherapy
影响因子：
4.9
作者：
Chery-Karschney,Laura;Patrapuvich,Rapatbhorn;Mudeppa,DevarajaGouda;Kokkonda,Sreekanth;Chakrabarti,Rimi;Sriwichai,Patchara;O'Connor,RobertaM;Rathod,PradipsinhK;White,John
通讯作者：
White,John

International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.

DOI：
10.4269/ajtmh.22-0005
发表时间：
2022-10-11
期刊：
The American journal of tropical medicine and hygiene
影响因子：
0
作者：
Mascarenhas A;Chakrabarti R;Chery-Karschney L;White J;Skillman KM;Kanjee U;Babar PH;Patrapuvich R;Mohanty AK;Duraisingh MT;Rathod PK
通讯作者：
Rathod PK

Microfluidic approaches to malaria pathogenesis.