An experimental study of the effects of alcohol intake on subsequent binge eating among adults with clinically-significant binge eating.

一项关于酒精摄入对有临床意义的暴食的成年人随后暴食影响的实验研究。

• 批准号: 10606227
• 负责人: Megan Wilkinson
• 金额: $ 4.68万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10606227
• 关键词: Acute; Adult; Alcohol consumption; Alcohols; Behavior; Beverages; Binge Eating; Binge eating disorder; Biological Markers; Blood alcohol level measurement; Bulimia; Calories; Clinical; Confounding Factors (Epidemiology); Consumption; Data; Data Analyses; Data Collection; Development; Diagnostic; Disinhibition; Dose; Eating; Eating Behavior; Eating Disorders; Emotions; Evidence based treatment; Experimental Designs; Frequencies; Future; Goals; High Prevalence; Hyperphagia; Individual; Individual Differences; Informal Social Control; Intervention; Interview; Knowledge; Laboratories; Literature; Maintenance; Measures; Medical; Mental Depression; Obesity; Overweight; Participant; Pattern; Physiological; Placebos; Recommendation; Reporting; Research; Research Design; Research Support; Risk; Role; Sampling; Standardization; Subgroup; Symptoms; Testing; Training; Woman; alcohol effect; alcohol research; anxiety symptoms; base; career; clinically significant; depressive symptoms; drinking; eating pathology; experience; experimental study; food consumption; heart rate variability; high risk; increased appetite; individualized medicine; loss of control over eating; non-alcoholic; psychiatric comorbidity

An experimental study of the effects of alcohol intake on subsequent binge eating among adults with clinically significant binge eating One potential maintenance factor of binge eating (i.e., the subjective experience of loss of control over eating) noted in the literature is alcohol consumption. Alcohol use, even at moderate levels, may increase likelihood for subsequent binge eating episodes due to its impact on stimulating appetite and increasing disinhibition. While cross-sectional retrospective research supports that individuals who drink more generally also engage in more frequent binge eating, no study to date has experimentally tested whether consuming a moderate amount of alcohol increases risk for a subsequent binge eating episode. Current treatment recommendations regarding alcohol use in individuals with binge eating do not give guidance on whether alcohol use should be modified and for whom these recommendations should be provided. In particular, there is reason to hypothesize that individuals with low self-regulation, more severe eating disorder symptoms, or less frequent/heavy alcohol consumption are at a higher risk for binge eating after drinking a moderate amount of alcohol. Given the high prevalence of alcohol use among individuals with binge eating, determining whether moderate alcohol consumption increases risk for subsequent binge eating is crucial for providing tailored evidence-based treatment recommendations regarding alcohol use. The current study will use a repeated measures experimental design to test the acute effect of alcohol on binge eating features (i.e., urges to binge eat, loss of control, calorie consumption) among adults with clinically significant binge eating (N = 60). Participants will complete physiological measures of self-regulation (i.e., heart rate variability) and clinical interviews of eating disorder symptoms and alcohol use patterns. In two counterbalanced study sessions, participants will receive a moderate dose of alcohol (blood alcohol concentration of 0.08%) or a non-alcoholic placebo before being provided an ad-libitum test meal. Ratings of urges to binge eat and loss of control, as well as calorie consumption, will be measured following the test meal. The aims of the study are to test if: (1) alcohol intake will be a stronger predictor of binge eating features than the placebo, and (2) individuals with low self- regulation (i.e., low heart rate variability) will endorse more binge eating features than those with high self- regulation. Secondary aims are to test the moderating effects of eating disorder symptoms and alcohol use patterns. This study will contribute significantly to the eating disorder field’s knowledge about the role of alcohol in the maintenance of binge eating. Additionally, completion of the current project will facilitate the applicant’s training in (1) experimental study designs in alcohol research, (2) lab-based measures of binge eating, (3) data collection and analysis of heart rate variability data, and (4) professional development. As such, the current project is an important and necessary step for the applicant to achieve their professional goals of an independent academic research career studying the effect of alcohol and substances on eating disorder maintenance and treatment.

一项关于酒精摄入对成年人随后暴饮暴食影响的实验研究