Tuskegee University Health Disparities Biomedical Research Center

塔斯基吉大学健康差异生物医学研究中心

• 批准号: 10606891
• 负责人: Channapatna S. Prakash
• 金额: $ 793.18万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606891
• 关键词: Address; African American population; Aging; Agriculture; Alabama; Area; Award; Basic Science; Behavior; Bioinformatics; Biological Sciences; Biomedical Research; Black race; COVID-19 pandemic; Chronic; Chronic Disease; Cities; Collaborations; Communicable Diseases; Complex; Computational Biology; Diabetes Mellitus; Diet and Nutrition; Disease; Diverse Workforce; Domestic Fowls; Drug Delivery Systems; Drug Targeting; Engineering; Environmental Risk Factor; Faculty; First Independent Research Support and Transition Awards; Foundations; Genetic Predisposition to Disease; Genomics; Graduate Education; Grant; Health Disparities Research; Individual; Infrastructure; Institution; Journals; Laboratories; Location; Malignant Neoplasms; Meat; Microscopy; Minority-Serving Institution; Modernization; Molecular Biology; Morbidity - disease rate; Morehouse School of Medicine; Natural Products; Obesity; Physical activity; Proteomics; Publications; Reduce health disparities; Research; Research Personnel; Research Training; Safety; Schools; Talents; Translations; Underserved Population; United States; United States National Institutes of Health; Universities; Veterinary Medicine; Veterinary Schools; Work; anticancer research; cancer genomics; digital pathology; genomic profiles; graduate student; health disparity; health equity; innovation; lifestyle factors; member; mortality; nano; novel strategies; novel therapeutics; prevent; programs; rural setting; symposium; tenure track; transcriptomics

OVER VIEW - Carver Research Foundation Annex – Center for Genomics and Health Disparity Research (CGHDR) We seek NIH support to build an annex to the existing historic Carver Research Building to locate our cutting-edge cancer genomics research, focusing on translational computation biology research. The new addition will accommodate the growing needs of the many biomedical researchers at Tuskegee University pursuing computational and wet-lab genomics research and the many researchers that we will hire soon. This addition will thus provide a modern infrastructure consistent with the sophisticated requirements of current biomedical research and the training of a diverse workforce. Health disparities are a focus and point of distinction in biomedical research at Tuskegee University, an Institution of Emerging Excellence. Health disparities-related diseases are the leading causes of morbidity and mortality in the United States and are very poignantly exemplified during the current COVID-19 pandemic. African Americans continue to suffer disproportionately from these and other chronic diseases, including obesity and diabetes – all influenced by individual genetic predisposition and environmental and lifestyle factors, including diet, nutrition, and physical activity. Tuskegee University is located in Alabama’s Black Belt (a term initially referring to the area’s black topsoil and now more often its predominantly African American population). The city of Tuskegee and the Black Belt are among the poorest regions in the U.S. We seek to become a globally renowned center of emerging excellence in cancer genomics with a focus on health disparities. In the last few years, our cancer research efforts have been increasingly focused on genomics, transcriptomics, computational biology, and digital pathology, resulting in numerous grants and publications in high-impact journals. However, our existing laboratory infrastructure in an aging building has become drastically inadequate to support such modern research endeavors. Additionally, we have recently been awarded the prestigious NIH FIRST award in collaboration with UAB, which will require us to hire 12 new tenure track faculty members, with three housed at Tuskegee. These new faculty will put additional demands for sophisticated laboratory infrastructure that are not available in our current facilities. The Biomedical Research Center at Tuskegee University is currently housed in the historic Carver Research Foundation. It supports multiple complementary research programs, including the Research Centers at Minority Institutions (RCMI) and the Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham (UAB) Comprehensive Partnerships to Address Cancer Health Equity (CPACHE). The Integrative Biosciences Doctoral Program (IBS) is uniquely poised to explore the genomic profile of underserved populations within Alabama's Black Belt. Collectively, these programs promote biomedical research that facilitates the translation of basic research to innovative new therapeutics and behaviors to reduce health disparities within Alabama's Black Belt region and the southeast region. The new annex to the Carver Research Building will be the first facility on Tuskegee University's campus devoted solely to biomedical research and graduate education. The CGHDR will consist of approximately 8,000 ft2 of green/sustainable newly constructed space that will house wet lab benches; bioinformatics/genomic core research work areas; offices for faculty, trainees, graduate students, and administrative staff supporting these researchers; and conference rooms. The complex will include an open lab format that will support five new laboratories and three core laboratories (Microscopy, Bioinformatics, and Genomics/Proteomics/Molecular Biology). The Research Building will be the first LEED-certified building on the Tuskegee University campus and one of few in the Black Belt region. The proposed center will provide a location to identify novel strategies for preventing and treating disease and advance the capabilities of all biomedical researchers at Tuskegee University. The new center will undoubtedly contribute to research on reducing health disparities in Alabama's Black Belt region and beyond. The center will also provide a valuable infrastructure to several other research groups on the campus, including agricultural genomics and natural products research, nano-targeted drug delivery in the School of Engineering, and infectious diseases, meat and poultry safety, and pathobiology within the School of Veterinary Medicine. Furthermore, the new building will also help us attract and retain high-quality scientific talent, a chronic challenge in Tuskegee’s rural setting.

观看 - Carver Research Foundation Annex - 基因组学与健康差异研究中心 （CGHDR） 我们寻求NIH支持，以建造现有历史悠久的Carver研究大楼的附件，以找到我们的尖端癌症 基因组学研究，重点是转化计算生物学研究。新添加将适应 杜斯基吉大学许多生物医学研究人员的需求不断增长 研究和许多我们将尽快聘请的研究人员。因此，此增加将提供现代基础设施一致 有了当前生物医学研究和潜水员劳动力的培训的复杂要求。 健康差异是杜斯基吉大学生物医学研究的重点和区别，这是一个 新兴的卓越。与健康分配相关的疾病是联合国发病和死亡率的主要原因 在当前的19日大流行期间，状态非常刺激。非裔美国人继续受苦 与这些慢性疾病（包括肥胖和糖尿病）相比，不成比例地 遗传易感性以及环境和生活方式因素，包括饮食，营养和体育锻炼。 Tuskegee 大学位于阿拉巴马州的黑带（最初指的是该地区的黑色表土，现在更常见 主要是非裔美国人人口）。塔斯基吉市和黑带是最贫穷的地区之一 美国 我们寻求成为全球著名的癌症基因组学卓越卓越中心，重点是健康分布。 在过去的几年中，我们的癌症研究工作已越来越集中于基因组学，转录组学， 计算生物学和数字病理学，在高影响期期刊中获得了许多赠款和出版物。 但是，我们在老化建筑物中现有的实验室基础设施已经变得非常不足以支持这种 现代研究努力。此外，我们最近获得了合作享有声望的NIH第一奖 与UAB一起，我们将要求我们聘请12名新的任期教职员工，其中3名位于Tuskegee。这些新 教师将对我们当前设施中无法提供的复杂实验室基础设施提出更多要求。 杜斯基吉大学的生物医学研究中心目前位于历史悠久的Carver研究基金会中。它 支持多个完整的研究计划，包括少数族裔机构（RCMI）和 莫尔豪斯医学院/托斯基吉大学/阿拉巴马大学伯明翰（UAB）综合 解决癌症健康平等（CPACHE）的合作伙伴关系。综合生物科学博士课程（IBS）是独特的 准备探索阿拉巴马州黑带中服务不足人群的基因组概况。这些程序共同 促进生物医学研究，以促进将基础研究转化为创新的新疗法和行为 减少阿拉巴马州黑带地区和东南地区内的健康差异。 Carver研究大楼的新附件将是Tuskegee University校园的第一个设施 生物医学研究和研究生教育。 CGHDR将由大约8,000 ft2组成的绿色/可持续性新近 建造的空间将容纳湿实验室长凳；生物信息学/基因组核心研究工作领域；教师办公室， 学员，研究生和行政人员支持这些研究人员；和会议室。综合大楼 包括一个开放式实验室格式，该格式将支持五个新实验室和三个核心实验室（显微镜，生物信息学，， 以及基因组学/蛋白质组学/分子生物学）。研究大楼将是LEED认证的第一座建筑 塔斯基吉大学校园，是黑带地区少数人之一。拟议的中心将提供一个位置来识别 预防和治疗疾病并提高塔斯基吉所有生物医学研究人员的能力的新型策略 大学。新中心无疑将有助于研究减少阿拉巴马州黑带健康差异的研究 地区及以后。该中心还将为校园其他几个研究小组提供宝贵的基础设施， 包括农业基因组学和天然产品研究，在工程学院以纳米为目标的药物输送， 以及兽医学院内的传染病，肉类和家禽安全以及病理学。此外， 这座新建筑还将帮助我们吸引和保留高质量的科学人才，这是塔斯基吉（Tuskegee）常规的长期挑战 环境。