Tuskegee University Health Disparities Biomedical Research Center

塔斯基吉大学健康差异生物医学研究中心

• 批准号: 10606891
• 负责人: Channapatna S. Prakash
• 金额: $ 793.18万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606891
• 关键词: Address; African American population; Aging; Agriculture; Alabama; Area; Award; Basic Science; Behavior; Bioinformatics; Biological Sciences; Biomedical Research; Black race; COVID-19 pandemic; Chronic; Chronic Disease; Cities; Collaborations; Communicable Diseases; Complex; Computational Biology; Diabetes Mellitus; Diet and Nutrition; Disease; Diverse Workforce; Domestic Fowls; Drug Delivery Systems; Drug Targeting; Engineering; Environmental Risk Factor; Faculty; First Independent Research Support and Transition Awards; Foundations; Genetic Predisposition to Disease; Genomics; Graduate Education; Grant; Health Disparities Research; Individual; Infrastructure; Institution; Journals; Laboratories; Location; Malignant Neoplasms; Meat; Microscopy; Minority-Serving Institution; Modernization; Molecular Biology; Morbidity - disease rate; Morehouse School of Medicine; Natural Products; Obesity; Physical activity; Proteomics; Publications; Reduce health disparities; Research; Research Personnel; Research Training; Safety; Schools; Talents; Translations; Underserved Population; United States; United States National Institutes of Health; Universities; Veterinary Medicine; Veterinary Schools; Work; anticancer research; cancer genomics; digital pathology; genomic profiles; graduate student; health disparity; health equity; innovation; lifestyle factors; member; mortality; nano; novel strategies; novel therapeutics; prevent; programs; rural setting; symposium; tenure track; transcriptomics

OVER VIEW - Carver Research Foundation Annex – Center for Genomics and Health Disparity Research (CGHDR) We seek NIH support to build an annex to the existing historic Carver Research Building to locate our cutting-edge cancer genomics research, focusing on translational computation biology research. The new addition will accommodate the growing needs of the many biomedical researchers at Tuskegee University pursuing computational and wet-lab genomics research and the many researchers that we will hire soon. This addition will thus provide a modern infrastructure consistent with the sophisticated requirements of current biomedical research and the training of a diverse workforce. Health disparities are a focus and point of distinction in biomedical research at Tuskegee University, an Institution of Emerging Excellence. Health disparities-related diseases are the leading causes of morbidity and mortality in the United States and are very poignantly exemplified during the current COVID-19 pandemic. African Americans continue to suffer disproportionately from these and other chronic diseases, including obesity and diabetes – all influenced by individual genetic predisposition and environmental and lifestyle factors, including diet, nutrition, and physical activity. Tuskegee University is located in Alabama’s Black Belt (a term initially referring to the area’s black topsoil and now more often its predominantly African American population). The city of Tuskegee and the Black Belt are among the poorest regions in the U.S. We seek to become a globally renowned center of emerging excellence in cancer genomics with a focus on health disparities. In the last few years, our cancer research efforts have been increasingly focused on genomics, transcriptomics, computational biology, and digital pathology, resulting in numerous grants and publications in high-impact journals. However, our existing laboratory infrastructure in an aging building has become drastically inadequate to support such modern research endeavors. Additionally, we have recently been awarded the prestigious NIH FIRST award in collaboration with UAB, which will require us to hire 12 new tenure track faculty members, with three housed at Tuskegee. These new faculty will put additional demands for sophisticated laboratory infrastructure that are not available in our current facilities. The Biomedical Research Center at Tuskegee University is currently housed in the historic Carver Research Foundation. It supports multiple complementary research programs, including the Research Centers at Minority Institutions (RCMI) and the Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham (UAB) Comprehensive Partnerships to Address Cancer Health Equity (CPACHE). The Integrative Biosciences Doctoral Program (IBS) is uniquely poised to explore the genomic profile of underserved populations within Alabama's Black Belt. Collectively, these programs promote biomedical research that facilitates the translation of basic research to innovative new therapeutics and behaviors to reduce health disparities within Alabama's Black Belt region and the southeast region. The new annex to the Carver Research Building will be the first facility on Tuskegee University's campus devoted solely to biomedical research and graduate education. The CGHDR will consist of approximately 8,000 ft2 of green/sustainable newly constructed space that will house wet lab benches; bioinformatics/genomic core research work areas; offices for faculty, trainees, graduate students, and administrative staff supporting these researchers; and conference rooms. The complex will include an open lab format that will support five new laboratories and three core laboratories (Microscopy, Bioinformatics, and Genomics/Proteomics/Molecular Biology). The Research Building will be the first LEED-certified building on the Tuskegee University campus and one of few in the Black Belt region. The proposed center will provide a location to identify novel strategies for preventing and treating disease and advance the capabilities of all biomedical researchers at Tuskegee University. The new center will undoubtedly contribute to research on reducing health disparities in Alabama's Black Belt region and beyond. The center will also provide a valuable infrastructure to several other research groups on the campus, including agricultural genomics and natural products research, nano-targeted drug delivery in the School of Engineering, and infectious diseases, meat and poultry safety, and pathobiology within the School of Veterinary Medicine. Furthermore, the new building will also help us attract and retain high-quality scientific talent, a chronic challenge in Tuskegee’s rural setting.

卡弗研究基金会附件-基因组学和健康差异研究中心 （CGHDR） 我们寻求国家卫生研究院的支持，在现有的历史性卡弗研究大楼的附件，以定位我们的尖端癌症 基因组学研究，侧重于翻译计算生物学研究。新增加的设施将容纳 塔斯基吉大学追求计算和湿实验室基因组学的许多生物医学研究人员日益增长的需求 研究和我们即将聘请的许多研究人员。因此，这一增加将提供一个现代化的基础设施， 随着当前生物医学研究的复杂要求和多样化劳动力的培训。 健康差异是塔斯基吉大学生物医学研究的一个焦点和区别点，塔斯基吉大学是一个研究机构， 新兴的卓越。在美国，与卫生保健有关的疾病是发病率和死亡率的主要原因。 在当前的COVID-19大流行期间，这些国家和地区都是非常尖锐的例子。非洲裔美国人继续遭受 不成比例地从这些和其他慢性疾病，包括肥胖和糖尿病-所有受个人影响 遗传易感性和环境及生活方式因素，包括饮食、营养和体力活动。Tuskegee 大学位于亚拉巴马的黑带（一个术语最初指的是该地区的黑色表土，现在更经常是它的 主要是非洲裔美国人）。塔斯基吉市和黑带是美国最贫穷的地区之一。 美国 我们致力于成为全球知名的癌症基因组学新兴卓越中心，专注于健康差异。 在过去的几年里，我们的癌症研究工作越来越多地集中在基因组学，转录组学， 计算生物学和数字病理学，导致许多赠款和高影响力期刊上的出版物。 然而，我们现有的实验室基础设施在一个老化的建筑物已成为严重不足，以支持这种 现代研究的努力。此外，我们最近还获得了著名的NIH FIRST合作奖， 与UAB合作，这将要求我们雇用12名新的终身教职员工，其中三人住在塔斯基吉。这些新 教师将对我们现有设施所不具备的先进实验室基础设施提出额外的要求。 塔斯基吉大学的生物医学研究中心目前位于历史悠久的卡弗研究基金会。它 支持多个互补的研究计划，包括少数民族机构研究中心（RCMI）， 莫尔豪斯医学院/塔斯基吉大学/亚拉巴马大学伯明翰分校（UAB）综合 癌症健康公平伙伴关系（CPACHE）。综合生物科学博士课程（IBS）是独一无二的 准备探索亚拉巴马黑带地区缺乏服务人群的基因组图谱。总的来说，这些方案 促进生物医学研究，促进基础研究转化为创新的新疗法和行为 以减少亚拉巴马黑带地区和东南部地区的健康差距。 卡弗研究大楼的新附属建筑将成为塔斯基吉大学校园内第一个专门用于 生物医学研究和研究生教育。CGHDR将包括约8，000平方英尺的绿色/可持续的新 建造空间，将容纳湿实验室工作台;生物信息学/基因组核心研究工作区;教师办公室， 实习生、研究生和支持这些研究人员的行政人员;以及会议室。该综合体将 包括一个开放实验室形式，将支持五个新实验室和三个核心实验室（显微镜，生物信息学， 和基因组学/蛋白质组学/分子生物学）。研究大楼将是第一个LEED认证的建筑， 塔斯基吉大学校园和少数在黑带地区之一。拟议的中心将提供一个地点，以确定 预防和治疗疾病的新策略，并提高塔斯基吉所有生物医学研究人员的能力 大学新中心无疑将有助于减少亚拉巴马黑带地区健康差距的研究 区域及以外。该中心还将为校园内的其他几个研究小组提供有价值的基础设施， 包括农业基因组学和天然产物研究，工程学院的纳米靶向药物输送， 动物医学院内的传染病、肉类和家禽安全以及病理生物学。此外，委员会认为， 新大楼还将帮助我们吸引和留住高素质的科学人才，这是塔斯基吉农村地区的一个长期挑战 设置.