Novel insights into the molecular mechanisms of manganese recognition and acquisition by pathogenic bacteria.

肺炎链球菌是世界上最重要的细菌病原体。在澳大利亚，细菌感染每年造成9000多人死亡，与治疗肺炎球菌感染引起的疾病相关的经济负担每年超过40亿美元。本提案旨在确定细菌如何从宿主环境中清除锰的分子基础。这一知识将为下一代抗菌疗法提供基础。

Streptococcus pneumoniae is the world’s foremost bacterial pathogen. In Australia, bacterial infections are responsible for more than 9000 deaths every year, and the economic burden associated with treating diseases arising from pneumococcal infections is more than $4 billion annually. This proposal aims to define the molecular basis of how bacteria scavenge manganese from the host environment. This knowledge will provide the foundation for next generation antimicrobial therapeutics.