The molecular basis for manganese uptake by pathogenic bacteria.

细菌耐药性对人类健康的威胁越来越大。在这个时间点上，迫切需要制定新的抗微生物战略。细菌感染涉及病原体和人类宿主之间持续不断的拉锯战，争夺生命的基本营养素，包括微量金属营养素，如锰。本项目旨在了解病原菌吸收锰的机制，以此作为新的抗菌设计的目标。

Bacterial antimicrobial resistance is an increasing threat to human health. At this point in time, there is an urgent, fundamental need for the development of new antimicrobial strategies. Bacterial infection involves a constant tug-of-war between the pathogen and the human host for the essential nutrients of life, including trace metal nutrients such as Mn. This project seeks to understand the machinery for Mn uptake by pathogenic bacteria as a target for novel antibacterial design.