Sleep induction by repetitive mechanosensory stimulation.
通过重复机械感觉刺激诱导睡眠。
基本信息
- 批准号:10608638
- 负责人:
- 金额:$ 42.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer&aposs disease pathologyAlzheimer&aposs disease patientArctic RegionsBiological ModelsBrainCessation of lifeCognitionCognitiveCorticotropin-Releasing HormoneDataDefectDisease ProgressionDiureticsDrosophila genusElderlyExhibitsFatigueFrequenciesGABA-B ReceptorGenesHealthHealth BenefitHomeostasisHomologous GeneHormonesHumanInfantInterventionInvertebratesMechanical StimulationMediatingMemoryMemory impairmentMindMolecularMotorMusNerve DegenerationNeurodegenerative DisordersNeurologicNeuronsNeuropeptidesNeurotoxinsOxidative StressPatientsPatternPersonsPlayPreventionProcessProtocols documentationResearchResistanceRoleSensorySensory ProcessShort-Term MemorySignal PathwaySignal TransductionSleepSleep DeprivationSleep DisordersSleep disturbancesSpecificityStimulusStressSuggestionSymptomsTestingWorkcognitive benefitsexperimental studyfamilial Alzheimer diseaseflygamma-Aminobutyric Acidhabituationimprovedinsightknock-downmemory consolidationneuromechanismnoveloverexpressionprematurereceptorrelating to nervous systemsleep regulationvibration
项目摘要
Project Summary
Sleep is essential for a healthy mind and body and is conserved from invertebrates to humans. Sleep serves
multiple functions, including memory consolidation, clearance of harmful metabolites, and prevention of
oxidative stress and premature death. Accumulating evidence suggests a bidirectional relationship between
sleep and neurodegenerative diseases such as Alzheimer’s disease (AD). AD patients often suffer from sleep
disruptions, while disrupted sleep accelerates AD pathologies. Importantly, improved sleep can ameliorate
memory deficits in a Drosophila model of AD, suggesting that sleep-related interventions could be an effective
strategy for treating AD patients. Sleep is regulated by multiple processes, including sensory processes.
Anecdotal observations suggest that babies sleep better when gently rocked or bounced, and several
experimental studies have confirmed that rocking promotes sleep in humans and mice. However, the
underlying mechanisms for this intriguing phenomenon are not well understood. Fly sleep is similar to human
sleep, and our recent finding that gentle vibration promotes sleep in flies provides an opportunity for
uncovering the mechanisms of sleep induction by mechanical stimulation. We found that flies sleep longer
during vibration and sleep shorter afterward, suggesting vibration-induced sleep (VIS) leads to the
accumulation of sleep credit. Preliminary data suggest VIS can also rescue memory deficits due to sleep loss
and enhance resistance to oxidative stress. Flies with reduced GABA signaling do not sleep more during
vibration, and preliminary data suggest that signaling through a neuropeptide called Diuretic Hormone 44 is
also involved in VIS. Building on these results, the proposed studies will investigate whether VIS confers
cognitive and health benefits of normal sleep in Drosophila models of AD and discover molecular and neural
mechanisms underlying VIS. Our work will provide a novel platform to study the mechanisms of sleep
regulation by repetitive mechanosensory stimulation and may suggest a non-invasive sleep-related
intervention for AD patients.
项目摘要
睡眠对健康的身心至关重要,从无脊椎动物到人类都有。睡眠服务
多种功能,包括记忆巩固,清除有害代谢物,预防
氧化应激和过早死亡越来越多的证据表明,
睡眠和神经退行性疾病如阿尔茨海默病(AD)。AD患者常因睡眠不足
干扰,而睡眠中断加速AD病理。重要的是,改善睡眠可以改善
AD果蝇模型的记忆缺陷,这表明睡眠相关的干预可能是一种有效的方法。
治疗AD患者的策略。睡眠是由多个过程调节的,包括感觉过程。
有趣的观察表明,婴儿在轻轻摇晃或弹跳时睡得更好,
实验研究已经证实,摇摆可以促进人和老鼠的睡眠。但
这一有趣现象的潜在机制尚未得到很好的理解。苍蝇的睡眠与人类相似
睡眠,我们最近发现,温和的振动促进睡眠的苍蝇提供了一个机会,
揭示机械刺激诱导睡眠的机制。我们发现苍蝇睡得更久
在振动和睡眠时间较短之后,这表明振动诱导睡眠(维斯)导致
睡眠积分的累积。初步数据表明,维斯还可以挽救睡眠不足造成的记忆缺陷
并增强对氧化应激的抵抗力。GABA信号减少的苍蝇在睡眠期间不会睡得更多。
振动,初步数据表明,通过一种名为利尿激素44的神经肽信号,
也参与了维斯。基于这些结果,拟议的研究将调查维斯是否赋予
在AD果蝇模型中研究正常睡眠对认知和健康的益处,
维斯的潜在机制。我们的工作将为睡眠机制的研究提供一个新的平台
通过重复的机械感觉刺激调节,并可能提示非侵入性睡眠相关
对AD患者进行干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kyunghee Koh其他文献
Kyunghee Koh的其他文献
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{{ truncateString('Kyunghee Koh', 18)}}的其他基金
Molecular and Neural Mechanisms of Sleep Regulation by TARANIS
TARANIS 睡眠调节的分子和神经机制
- 批准号:
9385776 - 财政年份:2017
- 资助金额:
$ 42.9万 - 项目类别:
Molecular and Neural Mechanisms of Sleep Regulation by TARANIS
TARANIS 睡眠调节的分子和神经机制
- 批准号:
8962253 - 财政年份:2015
- 资助金额:
$ 42.9万 - 项目类别:
Molecular and Neural Mechanisms of Sleep Regulation by TARANIS
TARANIS 睡眠调节的分子和神经机制
- 批准号:
9276800 - 财政年份:2015
- 资助金额:
$ 42.9万 - 项目类别:
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