Alcohol use, physical activity, and neurophysiological indicators of behavioral adaptability

饮酒、体力活动和行为适应性的神经生理学指标

• 批准号: 10609697
• 负责人: Andrew Antonio Ude
• 金额: $ 4.77万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609697
• 关键词: Acute; Address; Adult; Affect; Age; Alcohol abuse; Alcohol consumption; Alcohols; Back; Baroreflex; Behavior; Behavior Control; Behavior assessment; Behavioral; Biological; Blood Pressure; Brain; Cardiovascular system; Chronic; Communication; Cross-Sectional Studies; Development; Electrocardiogram; Electroencephalography; Event-Related Potentials; Exercise; Exhibits; Foundations; Future; Goals; Health; Health behavior; Heart; Heart Rate; Incentives; Individual; Individual Differences; Informal Social Control; Intervention; Interview; Intoxication; Knowledge; Longevity; Measures; Methodology; Monitor; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neural Pathways; Neurosciences; Parents; Patient Self-Report; Pattern; Periodicity; Persons; Physical activity; Process; Regulation; Research; Resources; Rest; Science; Stimulus; Strategic Planning; Testing; Training; United States National Institutes of Health; Withdrawal; actigraphy; addiction; alcohol cue; alcohol effect; alcohol measurement; alcohol research; alcohol use disorder; binge drinker; binge drinking; chronic alcohol ingestion; college; critical period; cue reactivity; design; drinking; emerging adult; emerging adulthood; experimental study; hazardous drinking; heart rate variability; high risk; high risk drinking; improved; incentive salience; neural; neuromechanism; neurophysiology; population health; programs; recruit; skills; social determinants; timeline; young adult

Project Summary and Abstract Health behaviors established during emerging adulthood often portend life-long behavior patterns. During this developmental stage, high-risk alcohol use behavior (binge-drinking) increases, while levels of physical activity begin to decrease. When considered individually, alcohol use and physical activity have marked and opposing influences on neurophysiological indicators of health and self-regulation. Acute and chronic alcohol negatively impact the cardiovascular system, resulting in decreased heart rate variability (HRV) and baroreflex sensitivity. High-risk drinking is also associated with greater incentive salience of alcohol cues, resulting in an enhanced P3 event-related potential to alcohol related stimuli (ACR-P3). Increased physical activity improves HRV, baroreflex sensitivity, and neural processes central to P3 amplitude reduction, although ACR-P3 has not been examined. Paradoxically, greater alcohol consumption consistently has been associated with more frequent physical activity across the adult lifespan. This raises the question of how the effects of this antagonistic clustering of co-occurring health-related behaviors accrue on the cardiovascular and neural processes that underlie their regulation. Further, a few recent studies suggest that this between-person association observed between alcohol use and physical activity may not reflect within-person drinking-activity relations, and most studies have relied on self-reports of physical activity. The goal of this study is to measure covariation in alcohol use and physical activity, assessed retrospectively, as well as objectively over a 7-10 day period to test the cumulative effects of drinking and activity behaviors on HRV, baroreflex sensitivity, and ACR-P3. The proposed research and training plan leverages the resources of a NIAAA-supported experiment (R21AA029604) examining whether a brief behavioral manipulation of the baroreflex loop can alter neural reactivity to alcohol cues in emerging adult binge drinkers. The proposed study will use simultaneously collected cardiovascular (ECG) and neural (EEG) measures recorded at rest and during an alcohol-cue reactivity paradigm from two sessions of the parent study, separated by 7-10 days. It will add on objective monitoring of physical activity during the intersession interval, combined with a time-line follow back interview of alcohol use and physical activity during the interval. Aim 1 is to examine covariation of alcohol use and physical activity behaviors assessed by self-report and actigraphy. Aim 2 is to examine the total effects of alcohol use and physical activity behaviors between sessions on HRV and baroreflex sensitivity (0.1Hz HRV). Aim 3 is to examine the cumulative effects of alcohol use and physical activity between sessions on incentive motivation towards alcohol cues, indicated by the ACR-P3. The proposed research and training plan are designed to address current gaps in understanding between drinking and activity behaviors to neurophysiological indicators of self-regulation, while providing the applicant with deeper knowledge and skills in alcohol research to support a developing research program on integrated cardiovascular and neural mechanisms in alcohol and co-occurring health behaviors.

项目摘要和摘要 在成年初期形成的健康行为往往预示着终生行为模式。在此期间 在发育阶段，高危饮酒行为(酗酒)增加，而体力活动水平 开始减少。当单独考虑时，饮酒和体力活动是显著的和相反的 对健康和自我调节的神经生理指标的影响。急、慢性酒精负性 影响心血管系统，导致心率变异性(HRV)和压力反射敏感性降低。 高风险饮酒还与酒精暗示的更大诱因显著相关，从而导致P3增强 酒精相关刺激事件相关电位(ACR-P3)。增加体力活动可改善HRV、压力感受器反射 敏感性，以及P3波幅降低的中枢神经过程，尽管ACR-P3尚未被检测到。 矛盾的是，更多的饮酒一直与更频繁的体力活动相关 在成年后的整个寿命里。这就提出了这样一个问题，即这种相互对立的共生集群的影响是如何 与健康相关的行为在心血管和神经过程中积累，这些过程是调节行为的基础。此外， 最近的一些研究表明，在饮酒和身体状况之间观察到的这种人与人之间的联系 活动可能不反映人与人之间的饮酒-活动关系，而且大多数研究都依赖于 体力活动。这项研究的目标是测量酒精使用和体力活动的协变性，评估 回顾和客观地在7-10天内测试饮酒和活动的累积影响 心率变异性、压力反射敏感性和ACR-P3的行为。拟议的研究和培训计划利用 NIAAA支持的一项实验(R21AA029604)的资源，该实验考察了一种简短的行为操纵 压力感受器反射回路的改变可以改变新兴的成年酗酒者对酒精暗示的神经反应。建议数 这项研究将使用同时收集的心血管(ECG)和神经(EEG)测量记录在休息和 在酒精线索反应范式期间，来自父母研究的两次会议，相隔7-10天。会的 在会话间歇期间增加对体力活动的客观监测，并结合时间线跟踪 回访休息期间的饮酒和体力活动情况。目标1是检验酒精的协变性。 通过自我报告和活动记录法评估使用和体力活动行为。目标2是检查总的影响 饮酒和运动行为对心率变异性和压力反射敏感性(0.1赫兹心率变异性)的影响。 目标3是检验饮酒和课间体育锻炼对激励的累积影响 对酒精暗示的动机，由ACR-P3所示。设计了拟议的研究和培训计划 解决目前饮酒和活动行为之间对神经生理学指标的理解差距 自律，同时为申请者提供更深入的酒精研究知识和技能，以支持 制定酒精和共生疾病中心血管和神经综合机制的研究计划 健康行为。