2023 Germinal Stem Cell Biology GRC & GRS

生殖干细胞生物学 生殖细胞谱系的诱导和编程 项目总结/摘要 胚胎干细胞是已知的最有效的干细胞群，能够产生所有的胚胎干细胞， 胚外细胞类型生殖系干细胞是第一个被认识到的干细胞群体，从那以后， 一直是研究的重点它们最终产生卵子和精子， 保护基因组并将其传递给下一代的责任。世界各地的研究人员 专注于了解生殖系干细胞是如何产生的，以及它们是如何在遗传和表观遗传方面受到调控的。 诱导和维持效力的水平，同时防止分化为体细胞的潜力 类型或形成肿瘤。从这项研究中吸取的教训对所有干细胞生物学和 对于了解生育能力和管理生殖疾病至关重要。合成生物学的发展速度 近年来，由于单细胞测序、表观遗传学和生物学等技术的进步， 分析和基因编辑。新方法使研究人员能够发现有效诱导细菌的方法， 从体细胞的起始群体，以及最近形成性腺体细胞谱系的细胞系潜能 从iPS细胞，可以潜在地支持小鼠，猴子和人类的生殖细胞发育。这些 这些发现推进了在体外产生配子用于生物医学如不孕症的希望， 以及生物技术的应用，如物种保护和牲畜管理。这次会议 将聚集生殖细胞研究前沿的国际科学家， 社区成员在该领域的发展。这次会议的重点是哺乳动物系统， 然而，经常包括最近取得进展的脊椎动物系统。我们的目标是让这个 会议是一个论坛，供对干细胞基础生物学感兴趣的科学家交流， 从事生殖细胞生物学和生育力临床相关方面的人员。尊重戈登的传统 研究会议，会议将是一个场地，提出未发表的数据和尖端的进步 在实地进行了讨论，随后进行了热烈的讨论。它将突出新兴概念和新的研究方向， 帮助建立跨学科和跨国家的合作。讨论的主题包括：规格 生殖细胞的生态位和信号，生殖细胞的异质性，环境x表观遗传 在生殖细胞系中编程，生殖细胞发育的代谢调节;生殖细胞的体外发育 性染色体和减数分裂;生殖系中的突变和非整倍体; RNA代谢 和生殖细胞发育的转录后控制;以及合成人类胚胎学的生物伦理学。

GRC: GERMINAL STEM CELL BIOLOGY Induction and Programming of the Germ Cell Lineage Project Summary/Abstract Germinal stem cells are the most potent known stem cell population, capable of giving rise to all embryonic and extraembryonic cell types. Germ line stem cells were the first stem cell population recognized and, ever since, have been the subject of intense research. They ultimately give rise to eggs and sperm and have the critical responsibility of guarding the genome and transmitting it to the next generation. Researchers around the world focus on understanding how germ line stem cells arise and how they are regulated at the genetic and epigenetic levels to induce and maintain potency while safeguarding against the potential to differentiate as somatic cell types or to form tumors. Lessons learned from this research have been instructive for all stem cell biology and are crucial for understanding fertility and managing reproductive disorders. The pace of synthetic biology has accelerated in recent years due to the advances in techniques such as single cell sequencing, epigenetic analysis, and gene editing. New methods have allowed researchers to discover ways of efficiently inducing germ line potency from a starting population of somatic cells and, more recently, of forming gonadal somatic lineages from iPS cells that can potentially support germ cell development in mice, monkeys, and humans. These discoveries advance the hope of producing gametes in vitro for applications in biomedicine such as infertility, and applications in biotechnology such as species preservation and livestock management. This conference will gather international scientists at the forefront of germ cell research with the goal of sharing the rapid developments in the field among community members. This conference is focused on mammalian systems, however vertebrate systems where recent advances have occurred are often included. We aim to make this conference a forum for exchange among scientists interested in the basic biology of germinal stem cells and those engaged in clinically relevant aspects of germ cell biology and fertility. Honoring the tradition of Gordon Research Conferences, the meeting will be a venue to present unpublished data and cutting-edge advancements in the field, followed by robust discussions. It will highlight emerging concepts and new research directions and help establish collaborations across disciplines and across nations. Topics to be discussed include: specification of the germ line, germ cell niches and signals, heterogeneity in the germ line, environment x epigenetic programming in the germ line, metabolic regulation of germ cell development; in vitro development of germ cells and fertility recovery; sex chromosomes and meiosis; mutation and aneuploidy in the germ line; RNA metabolism and post-transcriptional control of germ cell development; and the bioethics of synthetic human embryology.