2023 Mechanisms of Membrane Transport GRC & GRS

2023 GRC膜传输机制

• 批准号: 10609187
• 负责人: Janice L Robertson
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609187
• 关键词: Academia; Affect; Allosteric Regulation; Atomic Force Microscopy; Awareness; Brain; Cell membrane; Cells; Cellular Membrane; Communication; Country; Cryoelectron Microscopy; Data; Disease; Ensure; Environment; Epilepsy; Equity; Europe; Financial Support; Fluorescence Microscopy; Functional disorder; Future; Goals; Hour; Human body; International; Ion Channel; Lead; Lipid Bilayers; Location; Mass Spectrum Analysis; Mediating; Membrane; Membrane Proteins; Membrane Transport Proteins; Mental disorders; Mission; Mutation; National Institute of Neurological Disorders and Stroke; Nerve; Nerve Degeneration; Pain; Participant; Pathologic; Pathway interactions; Physiological; Physiology; Postdoctoral Fellow; Proteins; Pump; Regulation; Research; Research Personnel; Role; Running; Science; Scientist; Senior Scientist; Sex Bias; Spottings; Structure; Students; Techniques; Time; Training; Transmembrane Transport; Travel; Underrepresented Populations; United States National Institutes of Health; Universities; Woman; Work; addiction; body system; career; cohort; equity, diversity, and inclusion; graduate student; human disease; insight; macromolecular assembly; meetings; neurotransmission; novel therapeutic intervention; peer; pharmacologic; posters; programs; protein structure; recruit; sensory stimulus; single molecule; symposium

Abstract: The Mechanisms of Membrane Transport GRC has been running since 1966. The mission of this GRC is to advance the understanding of ion channels, transporters and ATP driven pumps at the structural, mechanistic and physiological levels. Membrane transport is fundamental to the physiology of all cells. The dysfunction of membrane transport proteins, including ion channels, transporters and pumps, is associated with numerous diseases affecting every organ system in the human body. In particular, these proteins are of critical importance in the brain where they mediate all aspects of neurotransmission, and in nerves where they propagate sensory stimuli such as pain. Even subtle dysfunction of these proteins due to mutations, regulatory changes or pathological conditions leads to devastating human diseases such as epilepsy, neurodegeneration, and addiction and mental disorders. A fundamental understanding of the mechanisms of membrane transporters paves pathways towards developing novel therapeutic strategies and increasing their utility as pharmacological targets. The 2023 GRC, subtitled “Unraveling the Mechanisms of Membrane Transport: Structure, Dynamics and Allosteric Regulation” aims to generate vigorous discussions with a specific emphasis on exploring rigorous mechanistic studies of membrane transport proteins within the context of their physiologic environments and in view of their specific roles in cells. The GRC also aims to provide an effective forum for promoting early-career and under-represented scientists, facilitating them in achieving their career goals in science. A Gordon Research Seminar, organized by graduate students and post-doctoral fellows, will run together with the GRC during the preceding two days. The 2023 GRS will serve to promote scientific research by junior attendees and to further NIH training priorities through discussions of career options and strategies, and of gender biases in academia.

摘要： 膜转运机制GRC自1966年以来一直在运行。本研究中心的使命是在结构、机制和生理水平上促进对离子通道、转运蛋白和ATP驱动泵的理解。膜转运是所有细胞生理学的基础。包括离子通道、转运蛋白和泵在内的膜转运蛋白的功能障碍与影响人体每个器官系统的许多疾病有关。特别是，这些蛋白质在大脑中至关重要，它们介导神经传递的所有方面，并且在神经中传播感觉刺激，如疼痛。由于突变、调节变化或病理条件导致的这些蛋白质的甚至细微的功能障碍都会导致毁灭性的人类疾病，如癫痫、神经变性、成瘾和精神障碍。对膜转运蛋白机制的基本理解为开发新的治疗策略和增加其作为药理学靶点的效用铺平了道路。2023年的GRC，副标题为“解开膜转运机制：结构，动力学和变构调节”，旨在产生积极的讨论，特别强调在其生理环境的背景下探索膜转运蛋白的严格机制研究，并考虑到它们在细胞中的特定作用。GRC还旨在为促进早期职业和代表性不足的科学家提供一个有效的论坛，促进他们在科学领域实现职业目标。由研究生和博士后研究员组织的戈登研究研讨会将在前两天与GRC一起举行。2023年的GRS将有助于促进初级参与者的科学研究，并通过讨论职业选择和战略以及学术界的性别偏见来进一步推动NIH的培训重点。