2023 Neuroimmune Communication in Health and Disease Gordon Research Conference and Gordon Research Seminar

项目摘要/摘要 该提案要求为研究生、博士后研究员和初级教员提供部分支持 参加戈登研究研讨会和会议(GRS和GRC)，题为“神经免疫” 健康与疾病中的沟通：组织功能中的神经免疫学：共享机制和 互惠互动“，将于2023年1月21-27日在加利福尼亚州文图拉举行。这个项目的总体目标是 国际会议是为了增加我们对调节神经免疫相互作用的机制的理解 在动态平衡和神经紊乱期间。神经免疫学领域已经有了相当大的发展。 在过去的二十年里，它已经成为生物医学研究中发展最快的学科之一。 神经免疫学GRC是专门为通过尖端会议捕捉该领域的广度而设计的 侧重于神经免疫系统如何调节健康的中枢神经系统和外周神经系统(PNS)和 疾病过程中的病理过程。因此，2021年方案将以以下主题会议开始 神经系统和免疫系统的共同进化，这是一个范式转换领域，提供了证据 这些系统最初是一个单独的系统，每个系统都是单独进化的，以应对微生物的暴露。 这次会议将聚集在这两个学科结合部工作的顶尖科学家，包括 教师和实习生是这一领域的新手。关于神经免疫复杂性的新概念 界面将在专题演讲和每日海报会议中进行探索和讨论。这是一种预期的力量 来自世界各地的科学家和神经免疫学领袖将出席会议 会议主席将邀请该领域的年轻科学家，特别是受训人员领导讨论。 健康和疾病中的神经免疫交流的主要会议主题GRC将介绍一些 当代该领域最令人兴奋的前沿研究领域，例如 在动态平衡和神经系统疾病中的小胶质细胞和胶质细胞，免疫对大脑功能的影响， 免疫和神经退行性疾病、血脑屏障和其他屏障的功能和 功能障碍、微生物群-中枢神经系统通讯、感染是慢性神经退行性变的触发因素 疾病和周围神经系统的神经免疫学。从这个过程中获得的信息 会议将通过数据驱动的讨论向神经免疫学领域提供信息和推动 突出该领域的广度和深度，以及需要解决的重要问题。神经免疫 机制涉及神经系统健康和功能的方方面面，并伴有扰动 导致神经细胞功能和病理过程中断，从而导致严重疾病。这 GRC将探索关于神经免疫相互作用作为基础的重要问题 神经系统的功能。

Project Summary / Abstract This proposal is requesting partial support for graduate students, post-doctoral fellows, and junior faculty to participate in the Gordon Research Seminar and Conference (GRS and GRC) entitled “Neuroimmune Communication in Health and Disease: Neuroimmunology in Organismic Function: Shared Mechanisms and Reciprocal Interactions”, which will be held in Ventura, CA on January 21-27, 2023. The overall goal of this international conference is to increase our understanding of mechanisms that regulate neuroimmune interactions during homeostasis and neurological disorders. The field of neuroimmunology has evolved considerably over the past two decades and emerged as one of the fastest moving disciplines in biomedical research. Neuroimmunology GRC is specifically designed to capture the breadth of the field through cutting-edge sessions focused on how the neuroimmune system regulates the healthy CNS and peripheral nervous system (PNS) and underlies pathologic processes during disease. As such, the 2021 program will begin with a keynote session on the co-evolution of the nervous and immune systems, a paradigm-shifting field that is providing evidence that these systems began as a single system that each evolved separately in response to exposures to microbes. The conference will congregate top tier scientists operating at the nexus between these two disciplines, including faculty and trainee newcomers to this field. Novel concepts pertaining to the complexities of the neuroimmune interface will be explored and discussed in featured talks and daily poster sessions. An intended strength of this meeting will be diverse representation of scientists from all over the world and neuroimmunology leaders as session chairs who will engage young scientists in the field, especially the trainees, to lead the discussions. The major session themes of Neuroimmune communication in health and disease GRC will capture some of the most exciting areas of contemporary cutting-edge research in the field, such as the role of microglia and glia during homeostasis and in neurological diseases, immune effects on brain function, immunity and neurodegenerative diseases, blood-brain barrier and other barriers' function and dysfunction, microbiome-CNS communication, infections as triggers of chronic neurodegenerative disease, and neuroimmunology of the peripheral nervous system. The information gained from this meeting will inform and advance the field of neuroimmunology through data-driven discussions that highlight the breadth and depth of the field, and important questions to be addressed. Neuroimmune mechanisms are involved in all aspects of nervous system health and function, with perturbations leading to disruption in neural cell function and pathologic processes that cause severe disease. This GRC will explore important questions regarding the role of neuroimmune interactions as fundamental to nervous system functions.