Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs

开发用于抗癫痫药物治疗药物监测的口内装置

• 批准号: 10609919
• 负责人: Elain Fu
• 金额: $ 16.71万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-14 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609919
• 关键词: Acceleration; Address; Algorithms; Antiepileptic Agents; Asthma; Beds; Biocompatible Materials; Biological Assay; Biological Markers; Blood; Blood capillaries; Capillarity; Carbamazepine; Caregivers; Chronic Obstructive Pulmonary Disease; Clinic; Clinical; Coupling; Data; Dental; Detection; Development; Devices; Diagnosis; Disease; Dose; Drug Interactions; Drug Kinetics; Drug Monitoring; Drug Side Effects; Electrodes; Electronics; Emerging Technologies; Epilepsy; Feedback; Future; Health; Healthcare; In Vitro; Individual; Intervention; Label; Laboratories; Machine Learning; Measurable; Measurement; Measures; Mental disorders; Microfluidic Microchips; Microfluidics; Modeling; Modification; Monitor; Noise; Oral; Oral cavity; Patients; Performance; Persons; Pharmaceutical Preparations; Process; Saliva; Salivary; Sampling; Secure; Seizures; Serum; Signal Transduction; Symptoms; Technology; Temperature; Therapeutic; Therapeutic Uses; Time; Toxic effect; Translating; Validation; Variant; Viscosity; Work; cross reactivity; dental resin; electronic sensor; handheld mobile device; health application; improved; individual variation; innovation; lamotrigine; meter; personalized health care; personalized management; pharmacologic; point of care; precision medicine; prototype; real time monitoring; salivary assay; sensor; signal processing; standard of care; wireless communication

PROJECT ABSTRACT Saliva is the ideal biofluid for therapeutic drug monitoring applications in general, and specifically for continuous monitoring because it is amenable to measurement noninvasively within the oral cavity. The development of an intraoral device for the continuous real-time monitoring of anti-epileptic drugs in saliva could enable the promise of precision medicine and advancing optimal dosing for each individual. In this project, we will demonstrate feasibility of our proposed intraoral sensor platform by coupling capillarity-based microfluidics and electrochemical detection to ultra-low-power readout electronics, and to use a machine-learning-based approach for offline processing of sensor data, to create an intraoral sensor for the real-time quantification of therapeutic drug levels in saliva in the presence of variation of salivary pH, temperature, and other common confounders. The intraoral sensor will consist of a reusable, comfortable electronics module that will fit securely into the patient’s mouth, and that interfaces with a disposable microfluidic chip containing voltammetry-based detection. The intraoral sensor electronics module will communicate wirelessly with a mobile device that will process the data and display and relay drug levels semi-continuously and in real time.

项目摘要

项目成果

A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces.

用于生物传感器接口的可重构三模式锁频环读出电路。

• DOI: 10.1109/tbcas.2023.3288505
• 发表时间: 2023
• 期刊: IEEE transactions on biomedical circuits and systems
• 影响因子: 5.1
• 作者: Yu,Siyuan;Chou,Tzu-Hsuan;Bose,Soumya;Cook,Jacob;Park,Jaehyeong;Johnston,MatthewL
• 通讯作者: Johnston,MatthewL