Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs

项目摘要 唾液通常是用于治疗药物监测应用的理想生物流体，特别是用于 连续监测，因为它可以在口腔内进行非侵入性测量。的 开发一种用于连续实时监测唾液中抗癫痫药物的口内装置， 实现精准医疗的承诺，并为每个人提供最佳剂量。本课题 将证明我们提出的口内传感器平台的可行性， 和电化学检测到超低功耗读出电子，并使用基于机器学习的 用于离线处理传感器数据的方法，以创建用于实时量化 唾液中的治疗药物水平在唾液pH值，温度和其他常见的变化的存在下， 混杂因素。口内传感器将包括一个可重复使用的，舒适的电子模块， 安全地进入患者的口腔，并与一次性微流控芯片连接， 伏安法检测口内传感器电子模块将与通信设备无线通信。 移动终端将处理数据并半连续地和真实的地显示和中继药物水平。

PROJECT ABSTRACT Saliva is the ideal biofluid for therapeutic drug monitoring applications in general, and specifically for continuous monitoring because it is amenable to measurement noninvasively within the oral cavity. The development of an intraoral device for the continuous real-time monitoring of anti-epileptic drugs in saliva could enable the promise of precision medicine and advancing optimal dosing for each individual. In this project, we will demonstrate feasibility of our proposed intraoral sensor platform by coupling capillarity-based microfluidics and electrochemical detection to ultra-low-power readout electronics, and to use a machine-learning-based approach for offline processing of sensor data, to create an intraoral sensor for the real-time quantification of therapeutic drug levels in saliva in the presence of variation of salivary pH, temperature, and other common confounders. The intraoral sensor will consist of a reusable, comfortable electronics module that will fit securely into the patient’s mouth, and that interfaces with a disposable microfluidic chip containing voltammetry-based detection. The intraoral sensor electronics module will communicate wirelessly with a mobile device that will process the data and display and relay drug levels semi-continuously and in real time.