Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs
开发用于抗癫痫药物治疗药物监测的口内装置
基本信息
- 批准号:10609919
- 负责人:
- 金额:$ 16.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-14 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAlgorithmsAntiepileptic AgentsAsthmaBedsBiocompatible MaterialsBiological AssayBiological MarkersBloodBlood capillariesCapillarityCarbamazepineCaregiversChronic Obstructive Pulmonary DiseaseClinicClinicalCouplingDataDentalDetectionDevelopmentDevicesDiagnosisDiseaseDoseDrug InteractionsDrug KineticsDrug MonitoringDrug Side EffectsElectrodesElectronicsEmerging TechnologiesEpilepsyFeedbackFutureHealthHealthcareIn VitroIndividualInterventionLabelLaboratoriesMachine LearningMeasurableMeasurementMeasuresMental disordersMicrofluidic MicrochipsMicrofluidicsModelingModificationMonitorNoiseOralOral cavityPatientsPerformancePersonsPharmaceutical PreparationsProcessSalivaSalivarySamplingSecureSeizuresSerumSignal TransductionSymptomsTechnologyTemperatureTherapeuticTherapeutic UsesTimeToxic effectTranslatingValidationVariantViscosityWorkcross reactivitydental resinelectronic sensorhandheld mobile devicehealth applicationimprovedindividual variationinnovationlamotriginemeterpersonalized health carepersonalized managementpharmacologicpoint of careprecision medicineprototypereal time monitoringsalivary assaysensorsignal processingstandard of carewireless communication
项目摘要
PROJECT ABSTRACT
Saliva is the ideal biofluid for therapeutic drug monitoring applications in general, and specifically for
continuous monitoring because it is amenable to measurement noninvasively within the oral cavity. The
development of an intraoral device for the continuous real-time monitoring of anti-epileptic drugs in saliva could
enable the promise of precision medicine and advancing optimal dosing for each individual. In this project, we
will demonstrate feasibility of our proposed intraoral sensor platform by coupling capillarity-based microfluidics
and electrochemical detection to ultra-low-power readout electronics, and to use a machine-learning-based
approach for offline processing of sensor data, to create an intraoral sensor for the real-time quantification of
therapeutic drug levels in saliva in the presence of variation of salivary pH, temperature, and other common
confounders. The intraoral sensor will consist of a reusable, comfortable electronics module that will fit
securely into the patient’s mouth, and that interfaces with a disposable microfluidic chip containing
voltammetry-based detection. The intraoral sensor electronics module will communicate wirelessly with a
mobile device that will process the data and display and relay drug levels semi-continuously and in real time.
项目摘要
唾液是治疗药物监测应用的理想生物流体,特别是
持续监测,因为它可以在口腔内进行非侵入性测量。这个
研制一种口腔内连续实时监测唾液中抗癫痫药物的装置
实现精准医疗的承诺,并推进每个人的最佳剂量。在这个项目中,我们
将展示我们建议的口腔内传感器平台的可行性,通过耦合基于毛细管的微流体
而电化学检测以超低功耗读出电子器件,并采用基于机器学习的方法
用于离线处理传感器数据的方法,以创建用于口腔内传感器的实时量化
治疗药物在唾液中的浓度在唾液pH、温度等常见情况下的变化
混血儿。口腔内传感器将由一个可重复使用的、舒适的电子模块组成,
安全地进入患者的口腔,并与包含以下内容的一次性微流控芯片接口
基于伏安法的检测。口腔内传感器电子模块将与一个
一种移动设备,将处理数据并半连续和实时显示和传递药物水平。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Reconfigurable Tri-Mode Frequency-Locked Loop Readout Circuit for Biosensor Interfaces.
用于生物传感器接口的可重构三模式锁频环读出电路。
- DOI:10.1109/tbcas.2023.3288505
- 发表时间:2023
- 期刊:
- 影响因子:5.1
- 作者:Yu,Siyuan;Chou,Tzu-Hsuan;Bose,Soumya;Cook,Jacob;Park,Jaehyeong;Johnston,MatthewL
- 通讯作者:Johnston,MatthewL
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Elain Fu其他文献
Elain Fu的其他文献
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{{ truncateString('Elain Fu', 18)}}的其他基金
Development of an intraoral device for therapeutic drug monitoring of anti-epileptic drugs
开发用于抗癫痫药物治疗药物监测的口内装置
- 批准号:
10452435 - 财政年份:2022
- 资助金额:
$ 16.71万 - 项目类别:
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