HIPC Data Coordinating Center

项目摘要/摘要 人类免疫学项目联盟(HIPC)成立于2010年，旨在创建一个独立的 专注于用高通量系统免疫学测量人类免疫反应的中心 方法与详细的临床表型相结合。我们建议建立一个重债穷国协调中心 这将更快、更有效地向更广泛的科学界提供数据，并为 通过增加在重债穷国中心进行的研究的价值，实现整个重债穷国的目标。与此同时，肝细胞癌将为 作为通过组织多中心分析项目和 集中式门户网站，提供思想交流的空间。具体来说，肝细胞癌将继续 开发共享数据标准，提供研究结果的中央知识库，建立工具以 可视化和分析数据，领导协同跨中心分析工作，提供门户以制作工具和 可广泛获取的数据，并为重债穷国小组委员会和 基础设施和机会基金(IOF)计划的管理。我们的团队拥有成熟的经验， 运行类似规模和复杂程度的程序。我们还对重债穷国网络有必要的熟悉， 我们的团队包括数据标准IOF项目、签名IOF项目、临床的当前PI 信息捕获和现有的免疫空间数据门户。这项提案综合利用了这一点 经验和基础设施，同时实施各种重大和必要的改进 由更紧密的整合和这笔专门的肝细胞癌赠款的5年时间范围推动。

PROJECT SUMMARY/ABSTRACT The Human Immunology Project Consortium (HIPC) was founded in 2010 to create a network of independent centers focused on measuring human immune responses with high-throughput systems immunology approaches coupled with detailed clinical phenotyping. We propose to develop a HIPC Coordinating Center (HCC) that will provide data more rapidly and effectively to the broader scientific community, and also serve the entire HIPC by increasing the value of the research performed at HIPC Centers. In parallel, the HCC will serve as a promoter of cross-HIPC collaborations through the organization of multi-center analysis projects and a centralized Portal to provide a space for the exchange of ideas. Specifically, the HCC will continue the development of shared data standards, provide a central Knowledgebase of study results, establish tools to visualize and analyze data, lead synergistic cross-center analysis efforts, provide a Portal to make the tools and data broadly accessible, and provide administrative support for the activities of HIPC subcommittees and management of the Infrastructure and Opportunity Fund (IOF) program. Our team has proven experience in running programs of similar scale and complexity. We also have the necessary familiarity with the HIPC network, with our team including current PIs of the Data Standards IOF project, the Signatures IOF project, clinical information capture, and the existing ImmuneSpace data portal. This proposal leverages this combined experience and infrastructure while, in parallel, implementing various significant and necessary improvements facilitated by the tighter integration and the 5-year time horizon of this dedicated HCC grant.