Texas Developmental Center for AIDS Research

项目摘要-德克萨斯州艾滋病研究发展中心 2019年，美国宣布了一项到2030年结束艾滋病毒流行的计划。要想取得成功，改进的战略 需要艾滋病毒预防和艾滋病毒治疗成果。只有56%的艾滋病毒感染者(PWH)是病毒携带者 2018年被抑制，这是健康结果和传播风险的关键决定因素，51%的艾滋病毒 2018年的诊断病例发生在美国南部，尽管只占美国人口的38%。德克萨斯州是 美国人口第二多的州，仅次于加利福尼亚州，约有2900万居民，位于美国 美国疾病控制与预防中心和人口普查局定义的南方。不幸的是，这个庞大的德克萨斯州人口，再加上 美国南部公共卫生和预防政策和资金薄弱，艾滋病毒人口不断增长 这在关键的健康结果方面是滞后的。迫切需要更多的研究和研究基础设施来 在美国南部，特别是德克萨斯州抗击艾滋病毒疫情，为结束美国艾滋病毒做出贡献 并学习如何在美国资源有限的地区最好地做到这一点。因此，我们将建立 德克萨斯州艾滋病研究发展中心(D-CFAR)支持国家艾滋病研究中心的总体使命 CFAR方案，促进高度优先的艾滋病毒研究，并支持#年结束艾滋病毒流行的努力 美国。三个机构合作提出了这个D-CFAR：休斯敦的贝勒医学院， 得克萨斯大学休斯顿健康科学中心和得克萨斯生物医学研究所 圣安东尼奥。基于其调查人员的杰出专业知识，德克萨斯州D-CFAR将专注于其 五年资助期内关于“消除艾滋病毒和优化艾滋病毒健康”研究主题的活动 德克萨斯州。“为了实现其目标，德克萨斯州D-CFAR将：1)提供组织和财务管理 并促进加强和丰富D-CFAR研究和智力的活动和方案 环境；2)支持有针对性的高优先级跨学科试点研究项目，协助应对 与爱滋病病毒有关的新研究计划，并促进有关终止爱滋病病毒和改善威尔斯亲王医院健康的研究 德克萨斯州；以及3)提供最先进的专业知识、建议和服务，以促进与艾滋病毒相关的一系列 为D-CFAR调查人员进行的研究。德克萨斯州D-CFAR将支持一个行政核心，一个发展 核心，基础科学核心和临床与生物统计学核心，以满足研究人员的需求和催化 创新研究。科学核心将建立在病毒学、非人类灵长类动物方面的突出优势之上。 资源、临床试验研究和生物统计学。D-CFAR将聘请社区咨询委员会和 内部和外部咨询委员会提供指导。再加上出色的机构支持，D- CFAR将促进基础、翻译、临床、卫生服务和 公共卫生研究人员。D-CFAR将极大地促进终止艾滋病毒和改善 在德克萨斯州和类似地区的PWH健康，培养下一代科学家，并成长为一个完整的 CFAR，从而为结束德克萨斯州、美国南部和其他地区的艾滋病毒流行做出了贡献。

PROJECT SUMMARY – TEXAS DEVELOPMENTAL CENTER FOR AIDS RESEARCH In 2019, the US announced a plan to End the HIV Epidemic by 2030. To be successful, strategies that improve HIV prevention and HIV treatment outcomes are needed. Only 56% of people with HIV (PWH) were virally suppressed in 2018, a critical determinant of health outcomes and transmission risk, and 51% of HIV diagnoses in 2018 were in the US South, despite constituting only 38% of the population in the US. Texas is the second most populous state in the US, behind California, with about 29 million residents, and is in the US South as defined by CDC and the Census Bureau. Unfortunately, this large Texas population, coupled with weaker public health and prevention policies and funding across the US South, has a growing HIV population that lags in critical health outcomes. There is an urgent need for more research and research infrastructure to combat the HIV epidemic in the US South and specifically in Texas to both contribute to ending the US HIV epidemic and to learn how to best do that in resource constrained areas of the US. We therefore will establish a Texas Developmental Center for AIDS Research (D-CFAR) to support the overall mission of the national CFAR program by facilitating high-priority HIV research and supporting the effort to end the HIV epidemic in the US. Three institutions have collaborated to propose this D-CFAR: Baylor College of Medicine in Houston, The University of Texas Health Science Center at Houston and the Texas Biomedical Research Institute in San Antonio. Based upon the outstanding expertise of its investigators, the Texas D-CFAR will focus its activities in the five-year funding period on the research theme “Ending HIV and Optimizing HIV Health in Texas.” To accomplish its goals, the Texas D-CFAR will: 1) Provide organizational and financial management and facilitate activities and programs that strengthen and enrich the D-CFAR research and intellectual environment; 2) Support targeted high-priority interdisciplinary pilot research projects, assist in responding to new HIV-related research initiatives, and facilitate research on ending HIV and improving health of PWH in Texas; and 3) Provide state-of-the-art expertise, advice, and services to facilitate the range of HIV-related research for D-CFAR investigators. The Texas D-CFAR will support an Administrative Core, a Developmental Core, a Basic Science Core and a Clinical and Biostatistics Core to meet investigator needs and catalyze innovative research. The scientific Cores will build on outstanding strengths in virology, non-human primate resources, clinical trials research and biostatistics. The D-CFAR will engage a Community Advisory Board and Internal and External Advisory Boards for guidance. Coupled with outstanding institutional support, the D- CFAR will stimulate new research and collaborations among basic, translational, clinical, health services and public health researchers. The D-CFAR will significantly advance knowledge needed to end HIV and improve the health of PWH in Texas and similar areas, train the next generation of scientists, and grow into a full CFAR, thereby contributing to ending the HIV epidemic in Texas, the US South, and beyond.