Wastewater Sampling: A New Tool to Accelerate Ending the HIV Epidemic
废水采样:加速结束艾滋病毒流行的新工具
基本信息
- 批准号:10762555
- 负责人:
- 金额:$ 77.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAccelerationAreaAuthorization documentationBioethics ConsultantsCOVID-19COVID-19 monitoringCOVID-19 outbreakCOVID-19 pandemicCaringClinical DataCollectionCommunitiesComplexDataData ReportingDetectionDiagnosisDiagnosticDiagnostic testsDisease OutbreaksEpidemicEpidemiologistEpidemiologyEthicsGeographic LocationsGeographyHIVHIV InfectionsHIV diagnosisHealthHumanHuman immunodeficiency virus testIndividualInfectionLaboratoriesLinkMethodsMonitorNeighborhoodsNoseNucleic AcidsPeriodicalsPersonsPhysiciansPlantsPoliomyelitisPopulationPreventionPublic HealthRecommendationReportingReproducibilityResearchResearch PersonnelResolutionResourcesSewageSexual PartnersSignal TransductionSiteTestingTimeViralViral Load resultWorkantiretroviral therapyauthoritycoronavirus diseaseepidemiological modelethical, legal, and social implicationexperiencehealth care availabilityimprovednovelnovel strategiesoutreachpredictive modelingpreferenceprogramspublic health interventionroutine caresewage treatmentsocial stigmasuccesssurveillance datatooltransmission processviral detectionvirologywastewater samplingwastewater testing
项目摘要
PROJECT SUMMARY
Current estimates are that 57% of persons in the U.S. with HIV are suppressed, leaving 43% unsuppressed,
including about 13% who are undiagnosed and 30% who have been diagnosed but are not currently
suppressed. Identifying persons with unsuppressed HIV to link them to care and antiretroviral treatment (ART)
is critical for improving health and reducing new infections. New epidemiologic tools that identify in real time
communities with high amounts of circulating HIV may enhance efforts to reduce HIV transmission and
substantially contribute to ending the HIV epidemic. During the SARS-CoV-2 (SCV2) pandemic, we and others
used “wastewater environmental virology” to monitor and respond to COVID. It uses viral capture and PCR
detection of viral nucleic acid from wastewater collection sites to detect, quantify, and predict total SCV2
activity in time. We built a robust and mature wastewater sampling program for the Houston region that
includes weekly assessment of 39 wastewater collection sites covering about 4 million residents. Our recent
preliminary data demonstrate that HIV is detected in wastewater. Wastewater testing is unbiased,
comprehensive, real-time, quantitative, and not influenced by access to health care, stigma or denial. We
hypothesize that our pioneering wastewater sampling program can be applied as a powerful new tool to
identify geographic areas with a high active burden of HIV, reflecting substantial numbers of people with
undiagnosed or untreated HIV infection. Resources can then be mobilized to these communities to enhance
HIV outreach, testing, prevention and linkage to care. The specifics aims are: 1) To develop a sensitive,
reproducible, and streamlined wastewater HIV detection pipeline; 2) To develop epidemiologic models
incorporating data from wastewater sampling as a novel and informative parameter along with routine
surveillance data on HIV diagnoses and population data; 3) To characterize and incorporate stakeholder
preferences, priorities, and recommendations for engaging key community stakeholders in the HIV wastewater
sampling program with consideration to the ethical, legal, social, and cultural contexts of individuals living in
target neighborhoods; 4) To determine if delivering proven public health interventions to neighborhoods as
directed by wastewater data can reduce the wastewater viral load and increase HIV diagnoses in those
neighborhoods. This research will enhance the Respond pillar of the End the HIV Epidemic (EHE) strategy. It
will leverage and strengthen partnerships between the researchers and the Houston Health Department, the
regional public health authority overseeing many EHE programs in Houston. The work in Houston, a high
priority EHE region, will result in: (i) the US’s only HIV wastewater sampling program, (ii) epidemiologic models
enhanced with wastewater data that identify unmet testing and treatment needs, (iii) community-informed and
ethically appropriate, real-time public health monitoring that reduces the number of people with unsuppressed
HIV, and (iv) tools and expertise that can be disseminated to other areas.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas P Giordano其他文献
The New Era of Long-Acting Antiretroviral Therapy: When and Why to Make the Switch
长效抗逆转录病毒治疗的新时代:何时以及为何进行转变
- DOI:
10.1007/s11904-023-00665-x - 发表时间:
2023 - 期刊:
- 影响因子:4.6
- 作者:
Melanie C Goebel;Emmanuel Guajardo;Thomas P Giordano;Shital M Patel - 通讯作者:
Shital M Patel
Thomas P Giordano的其他文献
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{{ truncateString('Thomas P Giordano', 18)}}的其他基金
VA Video Connect to Improve Access to Multi-disciplinary Specialty Care
VA 视频连接可改善获得多学科专业护理的机会
- 批准号:
10329924 - 财政年份:2020
- 资助金额:
$ 77.68万 - 项目类别:
VA Video Connect to Improve Access to Multi-disciplinary Specialty Care
VA 视频连接可改善获得多学科专业护理的机会
- 批准号:
9721402 - 财政年份:2020
- 资助金额:
$ 77.68万 - 项目类别:
VA Video Connect to Improve Access to Multi-disciplinary Specialty Care
VA 视频连接可改善获得多学科专业护理的机会
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10561628 - 财政年份:2020
- 资助金额:
$ 77.68万 - 项目类别:
Developing an Intervention to Retain HIV-infected Veterans in HIV Care
制定干预措施,让感染艾滋病毒的退伍军人继续接受艾滋病毒护理
- 批准号:
8182121 - 财政年份:2010
- 资助金额:
$ 77.68万 - 项目类别:
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