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Using the Multiphase Optimization Strategy to Optimize a Culturally Tailored Online Behavioral Weight Loss Intervention for Sexual Minority Women

使用多阶段优化策略优化针对性少数女性的文化定制在线行为减肥干预

基本信息

批准号：
10609850
负责人：
Emily Panza
金额：
$ 16.55万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10609850
关键词：
Address Affect Behavior Behavior Therapy Behavioral Bisexual Body Image Body Weight decreased Clinical Data Diabetes Mellitus Diet Disparity Eating Evaluation Exercise Feedback Focus Groups Future Goals Grant Health Heterosexuals Institute of Medicine (U.S.)Intervention Interview K-Series Research Career Programs LGBT Health Learning Lesbian Mediation Mental Depression Mentors Mentorship Methods Obesity Outcome Overweight Persons Phase Physical activity Population Preparation Public Health Qualifying Quality of life Randomized Randomized, Controlled Trials Reporting Research Research Priority Risk Same-sex Sexual Health Sexual and Gender Minorities Shapes Social support Stress Stress and Coping Structure Technology Testing Training Underserved Population United States National Institutes of Health Weight Weight Gain Wing Woman Work cardiometabolism cardiovascular disorder risk career clinically significant cost design evidence base experience experimental study gender minority health health disparity improved individualized medicine innovation interest intervention refinement minority stress moderate obesity multiphase optimization strategy novel obesity treatment phase 3 study pilot test programs sexual minority sexual minority women skill acquisition skills standard care substance use theories therapy development treatment optimization weight loss intervention weight loss program

项目摘要

PROJECT ABSTRACT Obesity disproportionately impacts sexual minority women. The goal of this K23 is to improve obesity treatments for sexual minority women by tailoring and optimizing an evidence-based online behavioral weight loss program to enhance weight loss in this group. This objective aligns with the research priorities outlined in NIH’s Notice of Special Interest in Research on the Health of Sexual and Gender Minorities (NOT-MD-19-001). Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity. Rx Weight Loss is an online behavioral weight loss program (co-developed by mentors on this K23) that is effective, low-cost, and highly scalable. However, existing research and the Candidate’s pilot work suggest that tailoring treatment to address 3 well-established weight loss barriers in sexual minority women will be critical for maximizing the relevance and efficacy of behavioral weight loss for this group. This K23 will tailor Rx Weight Loss to address sexual minority women’s weight loss barriers (i.e., minority stress, low social support, negative body image) and conduct an optimization trial to identify whether and how tailored components enhance weight loss outcomes in sexual minority women using the Multiphase Optimization Strategy (MOST). The Preparation Phase (Aim 1) will involve developing 3 novel treatment components targeting sexual minority women’s weight loss barriers and refining the intervention based on pilot testing and feedback from qualitative interviews with 20 sexual minority women. The Optimization Phase (Aim 2) will involve conducting a factorial experiment. 88 sexual minority women will receive 12 weeks of Rx Weight Loss and randomization to receive 0-3 tailored components. This data will be used to determine whether novel components - alone and in combination - impact mean weight loss and the proportion of women achieving clinically significant weight loss at 6 months (Aim 2A) and to clarify how tailored components affect weight loss by testing hypothesized mechanisms of action (Aim 2B). Novel components that increase mean weight loss by ≥2% or the proportion achieving 5+% weight loss by ≥10% will be retained in a final obesity treatment package to evaluate in a future RCT. This project builds on the Candidate’s prior work in sexual minority women and will be completed with guidance from a highly qualified and experienced mentorship team. The Candidate’s overarching goal in this K23 is to establish skills in applying cultural tailoring and innovative methods (e.g., technology- based treatment, MOST) to improve the relevance, efficacy, and impact of behavioral weight loss programs for sexual minority women. The mentorship, training, and experience provided by the K23 will allow the Candidate to acquire these skills and to launch an independent research career leveraging these skills to address obesity disparities in sexual minority women and other underserved groups.

项目摘要肥胖对性少数群体妇女的影响不成比例。这个K23的目标是改善肥胖通过定制和优化基于证据的在线行为权重来治疗性少数女性减肥计划，以加强减肥在这一组。这一目标与《生物多样性公约》中概述的研究优先事项一致，美国国立卫生研究院对性和性别少数群体健康研究特别感兴趣的通知（NOT-MD-19-001）。行为减肥计划是治疗轻度至中度肥胖的金标准。Rx减肥是一个在线行为减肥计划（由K23导师共同开发），有效，低成本，并且高度可扩展。然而，现有的研究和候选人的试点工作表明，解决性少数女性中3个公认的减肥障碍对于最大限度地提高女性的健康至关重要。行为减肥的相关性和有效性。此K23将定制Rx减肥，以解决性少数女性的减肥障碍（即，少数民族压力，低社会支持，负面的身体形象）并进行优化试验，以确定定制组件是否以及如何增强减肥效果使用多阶段优化策略（MOST）的性少数女性的结果。制备阶段（目标1）将涉及开发3种针对性少数女性体重的新型治疗成分根据试点测试和定性访谈的反馈， 20性少数女性优化阶段（目标2）将涉及进行析因实验。88 性少数女性将接受12周的Rx减肥，并随机接受0-3个量身定制的件.这些数据将用于确定新组分-单独和组合- 影响平均体重减轻和6个月时达到临床显著体重减轻的女性比例 (Aim 2A），并通过测试以下假设的机制来阐明定制的组分如何影响体重减轻：行动（目标2B）。使平均重量损失增加≥2%或比例达到5+%的新型成分体重减轻≥10%将保留在最终的肥胖治疗包中，以在未来的RCT中进行评价。该项目建立在候选人先前在性少数群体妇女方面的工作基础上，将于来自高素质和经验丰富的导师团队的指导。候选人的首要目标是该K23旨在培养应用文化定制和创新方法的技能（例如，技术- 基于治疗，MOST），以提高行为减肥的相关性，有效性和影响性少数群体妇女的项目。K23提供的指导、培训和经验将允许候选人获得这些技能并利用这些技能开始独立的研究生涯解决性少数群体妇女和其他得不到充分服务的群体中肥胖问题的技能。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Internalized weight stigma in women with class III obesity: A randomized controlled trial of a virtual lifestyle modification intervention followed by a mindful self-compassion intervention.

DOI：
10.1002/osp4.616
发表时间：
2022-12
期刊：
OBESITY SCIENCE & PRACTICE
影响因子：
2.2
作者：
Braun, Tosca D.;Olson, Kayloni;Panza, Emily;Lillis, Jason;Schumacher, Leah;Abrantes, Ana M.;Kunicki, Zachary;Unick, Jessica L.
通讯作者：
Unick, Jessica L.

Association of COVID-19 Stay-at-Home Orders With 1-Year Weight Changes.

DOI：
10.1001/jamanetworkopen.2022.17313
发表时间：
2022-06-01
期刊：
JAMA NETWORK OPEN
影响因子：
13.8
作者：
Wing, Rena R.;Venkatakrishnan, Kripa;Panza, Emily;Marroquin, Oscar C.;Kip, Kevin E.
通讯作者：
Kip, Kevin E.

Affective responses to overeating episodes in women participating in a behavioral weight loss program.

对参加行为减肥计划的女性暴饮暴食的情感反应。