Dissecting basal ganglia circuit mechanisms underlying instrumental learning
剖析仪器学习背后的基底神经节回路机制
基本信息
- 批准号:10609934
- 负责人:
- 金额:$ 36.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-30 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAnatomyBasal GangliaBehaviorBehavioralBehavioral AssayBilateralBrain StemBrain regionCell NucleusCellsCerebral cortexCollectionConsensusCorpus striatum structureDevelopmentDiseaseDopamine ReceptorExpectancyFeedbackFunctional disorderGoalsHabitsImpairmentLearningLesionMedialMental disordersMonitorMotionMotor CortexMovementMusNeuronsObsessive-Compulsive DisorderOperant ConditioningOutcomePathway interactionsPatternPerformancePlayPopulationPrefrontal CortexProcessPsychological reinforcementPyramidal TractsResearchRewardsRoleSchizophreniaShapesSignal PathwaySignal TransductionSpinal CordSymptomsTestingTransgenic MiceWorkaddictionassociation cortexexperimental studyflexibilitygenetic manipulationhippocampal pyramidal neuronin vivo calcium imaginglearning outcomemotor controlnervous system disorderneuralneural circuitneuromechanismoptogeneticsreceptorrecruit
项目摘要
SUMMARY
The basal ganglia (BG) are critical for motor control and instrumental learning. In particular, classic lesion
studies have demonstrated that different regions of the striatum, the major BG input nucleus, are
associated with distinct aspects of action selection and learning: the dorsomedial striatum is responsible
for action-outcome learning and action selection based on outcome expectancy, whereas the dorsolateral
striatum is responsible for the development of habits and behavioral automaticity. There is also growing
consensus that maladaptive instrumental learning and performance contribute to numerous disorders
such as addiction and schizophrenia that also implicate the BG. Although recent studies have begun to
show a key role for corticostriatal plasticity in instrumental learning and habit formation, the detailed circuit
mechanisms remain unclear. The overall aim of this proposal is to determine the circuit mechanisms in
the BG underlying instrumental learning and performance. We will use a integrative approach, combining
intersectional strategies to target defined neuronal populations and pathways and precise behavioral
assays to quantify learning and behavior. To monitor and manipulate neural activity of defined cell
populations, we will use in vivo calcium imaging, optogenetics, and transgenic mouse lines that make it
possible to target the key neuronal populations and pathways in the BG. To assess the content of
learning and quantify behavior continuously, we will use established behavioral assays from instrumental
conditioning combined with 3D motion capture. Four aims are proposed. Aims 1 and 2 will determine the
contribution of the direct (striatonigral) pathway and indirect (striatopallidal) pathways in different striatal
regions to instrumental learning and performance. Aims 3-4 will determine the contributions of distinct
corticostriatal pathways (intratelencephalic and pyramidal tract) to instrumental learning and
performance. Results from proposed research can shed light on the neural mechanisms underlying goal-
directed actions and habit formation, and how dysfunctions in the BG circuit mechanisms can result in
key symptoms of multiple psychiatric and neurological disorders.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Henry Yin其他文献
Henry Yin的其他文献
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{{ truncateString('Henry Yin', 18)}}的其他基金
The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
- 批准号:
10181420 - 财政年份:2021
- 资助金额:
$ 36.23万 - 项目类别:
The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
- 批准号:
10401927 - 财政年份:2021
- 资助金额:
$ 36.23万 - 项目类别:
The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
- 批准号:
10609886 - 财政年份:2021
- 资助金额:
$ 36.23万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10063566 - 财政年份:2017
- 资助金额:
$ 36.23万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10531242 - 财政年份:2017
- 资助金额:
$ 36.23万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10367065 - 财政年份:2017
- 资助金额:
$ 36.23万 - 项目类别:
Dissecting basal ganglia circuit mechanisms underlying instrumental learning
剖析工具学习背后的基底神经节回路机制
- 批准号:
10444477 - 财政年份:2016
- 资助金额:
$ 36.23万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10192835 - 财政年份:2014
- 资助金额:
$ 36.23万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10386923 - 财政年份:2014
- 资助金额:
$ 36.23万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10609460 - 财政年份:2014
- 资助金额:
$ 36.23万 - 项目类别:
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