The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
基本信息
- 批准号:10609886
- 负责人:
- 金额:$ 40.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-15 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalArchitectureAreaArousalAttentionBasal GangliaBehaviorBehavior monitoringBehavioralBehavioral AssayBypassCalciumCell NucleusCellsClinicalCorpus striatum structureDevelopmentDiseaseDissectionDopamineElectrophysiology (science)GangliaGenerationsImageImpairmentIndividualIntralaminar Nuclear GroupLearningLesionMediatingMental disordersMidbrain structureModernizationMotionMovementNeuronsOperant ConditioningOutputParafascicular NucleusPathway interactionsPhotonsPlayPopulationPopulation ProjectionPositioning AttributePrimatesProcessResolutionRoleSensory NeglectsStructureStructure of subthalamic nucleusSymptomsSystemThalamic structureWorkattentional controlcell typeenvironmental changeexperimental studyflexibilityin vivonervous system disorderneuralneural circuitnoveloptogeneticssuperior colliculus Corpora quadrigeminatooltreatment strategywireless
项目摘要
Project Summary
The parafascicular nucleus is a major nucleus in the so-called intralaminar group. Although it is
traditionally considered part of the reticular activating system and thought to play a role in
arousal and attention, its contributions to behavior are still poorly understood. Much of the work
on the Pf was done in primates before the development of modern intersectional strategies for
selective cell type targeting and neural circuit dissection. This proposal aims to elucidate the
computational functions of specific components of the Pf circuit, and to determine how this
circuit can be used for the control of attention and action selection. Preliminary results indicate
that the Pf plays a key role in rapid action generation, which appears to be mediated by direct
excitatory inputs from the deep/intermediate layers of the superior colliculus. Two populations
of Pf projection neurons target different downstream structures and have distinct behavioral
functions. We hypothesize that Pf projections to the subthalamic nucleus are especially
important for fast action initiation that bypasses the canonical basal ganglia circuitry, where as
the well-known Pf projections to the striatum is not needed for action initiation, suggesting that
the Pf-basal ganglia pathway has a distinct function. A highly integrative approach will be
employed, combining 1) Motion capture for continuous behavioral quantification in 3D; 2)
wireless in vivo recording from single neurons; 3) optogenetic manipulation of defined neuronal
populations; 4) 1-photon calcium imaging of genetically defined individual neurons; and 5)
quantitative operant behavioral assays. These tools will be used to determine how the Pf
processes inputs from the midbrain and uses this information to guide action selection via
distinct output projections to the STN and striatum.
项目摘要
束旁核是所谓板内核群中的主要核团。虽然
传统上被认为是网状激活系统的一部分,
唤醒和注意,它对行为的贡献仍然知之甚少。大部分工作
在现代交叉策略发展之前,
选择性细胞类型靶向和神经回路解剖。本建议旨在阐明
Pf电路的特定组件的计算功能,并确定这是如何
电路可用于控制注意力和动作选择。初步结果表明
Pf在快速作用的产生中起关键作用,这似乎是由直接介导的。
来自上级丘的深层/中层的兴奋性输入。两个群体
的Pf投射神经元靶向不同的下游结构,并具有不同的行为
功能协调发展的我们推测,Pf的投射到丘脑底核,特别是
重要的是快速行动启动,绕过典型的基底神经节电路,
众所周知的Pf向纹状体的投射并不需要动作启动,这表明,
Pf-基底神经节通路具有独特功能。高度综合的方法将是
采用,结合1)用于3D中的连续行为量化的运动捕捉; 2)
来自单个神经元的无线体内记录; 3)限定的神经元的光遗传学操纵
群体; 4)遗传定义的个体神经元的1光子钙成像;以及5)
定量操作行为分析。这些工具将用于确定Pf如何
处理来自中脑的输入,并使用这些信息来指导行动选择,
向纹状体和纹状体的不同输出投射。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Henry Yin其他文献
Henry Yin的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Henry Yin', 18)}}的其他基金
The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
- 批准号:
10181420 - 财政年份:2021
- 资助金额:
$ 40.11万 - 项目类别:
The Role of Parafascicular Thalamic Circuits in Action Generation
束旁丘脑回路在动作生成中的作用
- 批准号:
10401927 - 财政年份:2021
- 资助金额:
$ 40.11万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10063566 - 财政年份:2017
- 资助金额:
$ 40.11万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10531242 - 财政年份:2017
- 资助金额:
$ 40.11万 - 项目类别:
The Role of Opponent Basal Ganglia Outputs in Behavior
对手基底神经节输出在行为中的作用
- 批准号:
10367065 - 财政年份:2017
- 资助金额:
$ 40.11万 - 项目类别:
Dissecting basal ganglia circuit mechanisms underlying instrumental learning
剖析仪器学习背后的基底神经节回路机制
- 批准号:
10609934 - 财政年份:2016
- 资助金额:
$ 40.11万 - 项目类别:
Dissecting basal ganglia circuit mechanisms underlying instrumental learning
剖析工具学习背后的基底神经节回路机制
- 批准号:
10444477 - 财政年份:2016
- 资助金额:
$ 40.11万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10192835 - 财政年份:2014
- 资助金额:
$ 40.11万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10386923 - 财政年份:2014
- 资助金额:
$ 40.11万 - 项目类别:
Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation
产后静态神经干细胞激活的神经回路控制
- 批准号:
10609460 - 财政年份:2014
- 资助金额:
$ 40.11万 - 项目类别:
相似海外基金
Practical Study on Disaster Countermeasure Architecture Model by Sustainable Design in Asian Flood Area
亚洲洪泛区可持续设计防灾建筑模型实践研究
- 批准号:
17K00727 - 财政年份:2017
- 资助金额:
$ 40.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional architecture of a face processing area in the common marmoset
普通狨猴面部处理区域的功能架构
- 批准号:
9764503 - 财政年份:2016
- 资助金额:
$ 40.11万 - 项目类别:
Heating and airconditioning by hypocausts in residential and representative architecture in Rome and Latium studies of a phenomenon of luxury in a favoured climatic area of the Roman Empire on the basis of selected examples.
罗马和拉齐奥的住宅和代表性建筑中的火烧供暖和空调根据选定的例子,研究了罗马帝国有利的气候地区的奢华现象。
- 批准号:
317469425 - 财政年份:2016
- 资助金额:
$ 40.11万 - 项目类别:
Research Grants
SBIR Phase II: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第二阶段:用于基于闪存的存储的面积和能源效率高、无错误层的低密度奇偶校验码解码器架构
- 批准号:
1632562 - 财政年份:2016
- 资助金额:
$ 40.11万 - 项目类别:
Standard Grant
SBIR Phase I: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第一阶段:用于基于闪存的存储的面积和能源效率高、无错误层低密度奇偶校验码解码器架构
- 批准号:
1520137 - 财政年份:2015
- 资助金额:
$ 40.11万 - 项目类别:
Standard Grant
A Study on The Spatial Setting and The Inhavitant's of The Flood Prevention Architecture in The Flood Area
洪泛区防洪建筑空间设置及居民生活研究
- 批准号:
26420620 - 财政年份:2014
- 资助金额:
$ 40.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
- 批准号:
327691-2007 - 财政年份:2011
- 资助金额:
$ 40.11万 - 项目类别:
Discovery Grants Program - Individual
A FUNDAMENTAL STUDY ON UTILIZATION OF THE POST-WAR ARCHITECTURE AS URBAN REGENERATION METHOD, A case of the central area of Osaka city
战后建筑作为城市更新方法的基础研究——以大阪市中心区为例
- 批准号:
22760469 - 财政年份:2010
- 资助金额:
$ 40.11万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
- 批准号:
327691-2007 - 财政年份:2010
- 资助金额:
$ 40.11万 - 项目类别:
Discovery Grants Program - Individual
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
- 批准号:
327691-2007 - 财政年份:2009
- 资助金额:
$ 40.11万 - 项目类别:
Discovery Grants Program - Individual