Reprogramming of tissue structural cells by cutaneous CD4+ T cells

皮肤 CD4 T 细胞对组织结构细胞的重编程

基本信息

项目摘要

Project Summary/Abstract Although long thought to be a unique feature of adaptive cells such as T and B cells, it is now clear that tissue structural cells can also harbor ‘memory’ of prior inflammatory responses in the form of stable epigenetic modifications that alter their transcriptional potential and behavior following subsequent tissue damage, and this is referred to as ‘inflammatory memory’. This highlights key gaps in our knowledge of T cell-tissue cross- talk that this proposal seeks to address. The premise of this proposal is that cutaneous T cells reprogram local keratinocytes and fibroblasts during inflammation, thereby altering their transcriptional and epigenetic landscape, function, and responses to subsequent stimuli, and that this influences the course and resolution of inflammatory skin disease. To fill these key knowledge gaps, we will examine the cross-talk between T cell and structural cells in innovative cell culture systems to monitor changes in cell behavior and function, and mechanistically link them to transcriptional and epigenetic reprogramming by T cell-derived cytokines. We will also leverage an established and highly manipulatable murine model of T cell-dependent skin inflammation to examine the development of inflammatory memory in KCs and Fibs in vivo, to mechanistically identify important cytokines and epigenetic mediators, and to assess the functional consequences on subsequent inflammatory and tissue-repair responses. Finally, we will analyze signatures of inflammatory memory in tissue samples from patients with the common skin inflammatory diseases psoriasis and atopic dermatitis, and assess epigenetic reprogramming in a preclinical model as a new therapeutic modality to reset inflammatory memory and break the inflammatory cycle in the skin of these patients.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Daniel J Campbell其他文献

133 CARDIAC PERFORMANCE, EXERCISE CAPACITY AND PULMONARY FUNCTION AFTER FONTAN SURGERY
Fontan 手术后心脏功能、运动能力和肺功能
  • DOI:
    10.1203/00006450-198504000-00163
  • 发表时间:
    1985-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    David G Ruschhaupt;Daniel J Campbell;Otto G Thilenius;Robert L Replogle;Rene A Arcilla
  • 通讯作者:
    Rene A Arcilla
Evaluating YouTube Videos on Facelift Surgery for Facial Rejuvenation as a Resource for Patients
评估有关面部年轻化整容手术的 YouTube 视频作为患者的资源
  • DOI:
    10.1177/00034894231154410
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zachary T Elliot;Joseph S Lu;Daniel J Campbell;Kevin B Xiao;Vanessa Christopher;Howard Krein;R. Heffelfinger
  • 通讯作者:
    R. Heffelfinger
Differences in Functional and Survival Outcomes Between Patients Receiving Primary Surgery vs Chemoradiation Therapy for Treatment of T1-T2 Oropharyngeal Squamous Cell Carcinoma.
接受初次手术与放化疗治疗 T1-T2 口咽鳞状细胞癌的患者功能和生存结果的差异。
  • DOI:
    10.1001/jamaoto.2023.1944
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Dev R Amin;R. Philips;Dylan G Bertoni;Eric V Mastrolonardo;Daniel J Campbell;A. Agarwal;Sruti Tekumalla;Zachary D Urdang;A. Luginbuhl;D. Cognetti;Joseph M. Curry
  • 通讯作者:
    Joseph M. Curry
Evaluating ChatGPT responses on thyroid nodules for patient education.
评估 ChatGPT 对甲状腺结节的反应以进行患者教育。
Evaluating ChatGPT Responses on Atrial Fibrillation for Patient Education
评估 ChatGPT 对心房颤动的反应以进行患者教育
  • DOI:
    10.7759/cureus.61680
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Thomas J Lee;Daniel J Campbell;Abhinav K Rao;Afif Hossain;Omar Elkattawy;Navid Radfar;Paul Lee;Julius M Gardin
  • 通讯作者:
    Julius M Gardin

Daniel J Campbell的其他文献

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{{ truncateString('Daniel J Campbell', 18)}}的其他基金

Mechanisms of Il-2-mediated immune tolerance
IL-2介导的免疫耐受机制
  • 批准号:
    10608299
  • 财政年份:
    2023
  • 资助金额:
    $ 64.57万
  • 项目类别:
Control of CD8+ T cell migration and activation by Flightless-1
Flightless-1 控制 CD8 T 细胞迁移和激活
  • 批准号:
    10155177
  • 财政年份:
    2021
  • 资助金额:
    $ 64.57万
  • 项目类别:
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance
IL2/IL2RA依赖性免疫耐受中自身免疫性疾病风险的机制
  • 批准号:
    10358624
  • 财政年份:
    2021
  • 资助金额:
    $ 64.57万
  • 项目类别:
Control of CD8+ T cell migration and activation by Flightless-1
Flightless-1 控制 CD8 T 细胞迁移和激活
  • 批准号:
    10366045
  • 财政年份:
    2021
  • 资助金额:
    $ 64.57万
  • 项目类别:
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance
IL2/IL2RA依赖性免疫耐受中自身免疫性疾病风险的机制
  • 批准号:
    10553203
  • 财政年份:
    2021
  • 资助金额:
    $ 64.57万
  • 项目类别:
Regulation of cutaneous immunity and tissue-repair by a specialized population of CD4+ T cells
特殊 CD4 T 细胞群对皮肤免疫和组织修复的调节
  • 批准号:
    9384627
  • 财政年份:
    2017
  • 资助金额:
    $ 64.57万
  • 项目类别:
Regulation of cutaneous immunity and tissue-repair by a specialized population of CD4+ T cells
特殊 CD4 T 细胞群对皮肤免疫和组织修复的调节
  • 批准号:
    9926223
  • 财政年份:
    2017
  • 资助金额:
    $ 64.57万
  • 项目类别:
Targeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal models
靶向 IL-2/调节性 T 细胞轴在真实动物模型中预防自身免疫性疾病
  • 批准号:
    10307124
  • 财政年份:
    2017
  • 资助金额:
    $ 64.57万
  • 项目类别:
Targeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal models
靶向 IL-2/调节性 T 细胞轴在真实动物模型中预防自身免疫性疾病
  • 批准号:
    10062808
  • 财政年份:
    2017
  • 资助金额:
    $ 64.57万
  • 项目类别:
Control of CD8+ T cell activation and differentiation by the signaling adaptor BCAP
信号适配器 BCAP 控制 CD8 T 细胞活化和分化
  • 批准号:
    9177685
  • 财政年份:
    2016
  • 资助金额:
    $ 64.57万
  • 项目类别:

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通过不依赖核酸的单细胞微生物组分析阐明特应性皮炎病理学
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以NC小鼠过敏敏感性为重点的特应性皮炎发病机制的遗传分析。
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阐明特应性皮炎相关脑炎症的发病机制
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特应性皮炎全身免疫调节治疗的活体系统评价和网络荟萃分析
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定义 IL-18 在特应性皮炎中的作用
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