2023 Nitric Oxide GRC and GRS

2023 一氧化氮 GRC 和 GRS

• 批准号: 10608028
• 负责人: Andrew J Gow
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608028
• 关键词: Address; Air Pollutants; Alzheimer' s Disease; Asthma; Athletic; Award; Bacteria; Basic Science; Biochemistry; Blood Vessels; Budgets; COVID-19 pandemic; COVID-19 patient; COVID-19 pneumonia; California; Carcinogens; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Chemistry; Collaborations; Communities; Complex; Consumption; Data; Detection; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Disease Resistance; Dose; Endothelium-Dependent Relaxing Factors; Environment; Enzymes; Explosion; Failure; Fostering; Functional disorder; Funding; Gender; Generations; Goals; Health; Health Status; Hemoglobin; Human; Human Biology; Human body; Hypertension; Inflammation; International; Life; Lung; Lung diseases; Mission; Molecular; Nature; Nitric Oxide; Nitric Oxide Synthase; Nitrous Oxide; Nobel Prize; Oral; Organism; Oxides; Participant; Pathology; Patients; Performance; Pharmacology and Toxicology; Physicians; Physiological; Physiology; Play; Postdoctoral Fellow; Preparation; Production; Reaction; Recording of previous events; Relaxation; Request for Proposals; Research; Research Personnel; Role; Running; Science; Scientist; Signal Pathway; Signal Transduction; Signaling Molecule; Source; Structure; System; Therapeutic; Therapeutic Intervention; Time; Training; Translational Research; United States National Institutes of Health; Universities; Vascular System; Work; body system; design; ethnic minority; experience; graduate student; human disease; improved; inhaled nitric oxide; insight; interest; meetings; member; neonatal pulmonary hypertension; next generation; novel; novel therapeutics; parity; posters; prevent; professor; programs; racial minority; respiratory health; skills; supportive environment; symposium; synergism

PROJECT SUMMARY This proposal requests partial support for a meeting on the “Molecular Mechanisms of Nitric Oxide Signaling in Health and Disease” as a Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) to be held in Ventura California from February 12th -17th 2023. The broad and long-term goal of this conference is to bring together the world's leading researchers in this field to foster cross-disciplinary discussions and collaborations. The meeting is designed to enhance our understanding of Nitric Oxide as a regulator of physiological function and as such an important target for control in both health and disease. In particular, we are interested in emphasizing how restoring appropriate Nitric Oxide signaling can alleviate diseases as varied as diabetes, hypertension, asthma, and COVID-19 related pneumonia. The 2023 conference will include a GRS for trainees held immediately prior to and in conjunction with the GRC. The specific aims of this meeting will be to convene over 35 leading experts who will present unpublished data and insights within the field of Nitric Oxide research. The GRC program will be structured into 9 sessions that comprehensively cover the field with sessions focused on cardiovascular performance, molecular mechanisms of signaling, Nitric Oxide generation and detection, and the role of Nitric Oxide in respiratory health. Both basic and translational research will be highlighted, with a major emphasis on physiological signaling and disruptions of this system that can be targeted to improve human health. Afternoon poster sessions will permit all participants to contribute to these topics with the most meritorious abstracts chosen by the conference Chair and Vice-Chair for oral presentations. Every effort will be made to encourage participation by graduate students and postdoctoral fellows in the GRC. In addition, the GRS will be specifically aimed at trainees, allowing them to present their research and interact in a relaxing and extra supportive environment. Every effort will be made to promote gender parity and include racial/ethnic minorities and persons with disabilities. The significance of this application lies in the much needed forum provided by the GRC and GRS to bring together and synergize the members of an international research community working on Nitric Oxide. Nitric Oxide research is unique in that it brings together chemists, environmental scientists, pulmonary and cardiovascular physicians. The Gordon conference on NO which has run since 1995 provides one of the only venues that brings together this diverse group and promotes transformational research ideas. The GRS will have the added value of helping to train and energize the next generation of researchers in the field. The need for greater understanding of how Nitric Oxide is critical to normal human function has only been made more apparent in the recent COVID pandemic. Nitric Oxide based detection and delivery systems are currently in use to not only treat patients, but to improve general health levels and improve resistant to disease. The investigators brought together by this conference have the potential to bring about true transformational change in human health.

项目摘要 该提案要求部分支持关于“一氧化氮信号传导的分子机制， 健康与疾病”作为戈登研究会议（GRC）和戈登研究研讨会（GRS）将 2023年2月12日至17日在加州文图拉举行。这次会议的广泛和长期目标是 汇集世界领先的研究人员在这一领域，以促进跨学科的讨论， 合作。会议旨在提高我们对一氧化氮作为一种调节剂的理解， 生理功能，并作为健康和疾病控制的重要目标。我们尤其 有兴趣强调如何恢复适当的一氧化氮信号可以减轻疾病， 如糖尿病、高血压、哮喘和COVID-19相关肺炎。2023年会议将包括一个 GRS为学员举行之前，并与GRC一起。本次会议的具体目标 将召集超过35位领先的专家，他们将在以下领域提供未发表的数据和见解： 一氧化氮研究GRC计划将分为9个会议，全面涵盖该领域 会议集中在心血管性能，信号传导的分子机制，一氧化氮 产生和检测，以及一氧化氮在呼吸系统健康中的作用。基础和翻译 研究将突出，主要强调生理信号和中断这一系统 可以用来改善人类健康下午的海报会议将允许所有与会者 通过会议主席和副主席选择的最有价值的摘要为这些主题做出贡献 口头报告。将尽一切努力鼓励研究生的参与， 研究生院的博士后研究员此外，GRS将专门针对学员，让他们 展示他们的研究，并在一个放松和额外的支持环境中互动。将尽一切努力 促进性别平等，并将少数种族/族裔和残疾人包括在内。其意义 应用在于GRC和GRS提供的急需的论坛，以汇集和协同 一氧化氮的国际研究团体的成员。一氧化氮的研究是独一无二的， 它汇集了化学家，环境科学家，肺和心血管医生。的 自1995年以来，戈登关于NO的会议提供了唯一一个将这一点聚集在一起的场所。 多样化的群体，促进变革性的研究思路。GRS的附加价值在于帮助 培养和激励该领域的下一代研究人员。需要更好地了解 一氧化氮对正常人体功能至关重要，这一点在最近的COVID中更加明显 流行病基于一氧化氮的检测和递送系统目前不仅用于治疗患者， 以改善总体健康水平和提高对疾病的抵抗力。调查人员聚集在一起， 会议有可能为人类健康带来真正的变革性变化。