Correlates of protective immunity to HCV and rational vaccine design: Admin Core

HCV 保护性免疫与合理疫苗设计的相关性：Admin Core

• 批准号: 10608106
• 负责人: Arash Grakoui
• 金额: $ 9.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608106
• 关键词: Address; Annual Reports; B-Lymphocytes; Biometry; Budgets; Clinical; Collaborations; Communities; Complex; Consultations; Databases; Dedications; Development; Ensure; Goals; Hepatitis C; Hepatitis C virus; Human; Immune response; Immunity; Individual; Infection; Infrastructure; Institution; Intellectual Property; Leadership; Methodology; Modification; Outcome; Patients; Postdoctoral Fellow; Productivity; Publications; Publishing; Research; Research Personnel; Research Project Grants; Resolution; Resource Allocation; Resources; Role; Scientist; Services; Technology Transfer; United States National Institutes of Health; Universities; Vaccine Design; Work; antigen-specific T cells; data management; data sharing; design; graduate student; meetings; nonhuman primate; novel vaccines; programs; response; symposium; vaccination strategy

Abstract In this program, we propose to determine the correlates of protection in individuals that spontaneously clear multiple HCV infection episodes. This will give highly valuable information for the design of next generation of vaccines. Our goal to assess the role of antigen-specific T and B cell responses in infection outcome and to generate an efficacious immune response by vaccination strategies in non-human primates based on emulating successful resolution of natural re-exposure and re-infection in human patients. This U19 proposal consists of 3 Projects and two Cores consisting of an Administrative Core A and a Clinical Core B. The Administrative Core A will provide two functions: (i) provide overall administrative oversight and support for the Program and (ii) provide biostatistical analyses and data management support for the individual projects and Cores. This Administrative Core will be led by Dr. Grakoui at Emory University and will provide the coordination necessary to make effective and efficient use of resources and intermediate results from this collaborative effort. The primary function will be to facilitate scientific interactions between the Project leaders as well as Core leaders. The administrative component will provide the leadership to ensure milestones are met, assessment of the Core functions, modification of scientific goals, incorporation of any new collaborators, decisions of ongoing prioritization and reallocation of resources. Critical decisions will be made in consultation with the Project leaders and program official at NIH. The Administrative Core will file annual reports to the NIH. The Administrative Core will maintain budgets and oversee any re-budgeting that is needed to meet program goals. The biostatistics portion of the Administrative Core will provide data management and statistical support for the three projects. In addition, the Biostatics portion will establish and maintain appropriate database, management and analysis in response to investigators' requests. In order to provide services to meet the analytical challenges the Core will include facilitating methodologies necessary for addressing complex statistical issues encountered in various research projects. In addition, provide essential metrics between the clinicians, scientists and biostatisticians. Having resources dedicated to the biostatistics and data management needs for the research proposed here, will add enormous value to the quality and productivity of the research conducted by the Investigators and to disseminate this information correctly to the scientific community.

摘要 在这个项目中，我们建议确定个人自发清除的保护相关因素， 多次HCV感染发作。这将为下一代的设计提供非常有价值的信息 疫苗。我们的目标是评估抗原特异性T和B细胞应答在感染结果中的作用， 在非人灵长类动物中通过疫苗接种策略产生有效的免疫应答 成功解决了人类患者的自然再暴露和再感染。 本U19提案包括3个项目和两个核心，包括行政核心A和临床核心B。 核心B。行政核心A将提供两项职能：㈠提供全面行政监督， 支持该计划;（ii）为个人提供生物统计分析和数据管理支持 项目和核心。该行政核心将由埃默里大学的Grakoui博士领导，并将提供 进行必要的协调，以有效和高效地利用资源和由此产生的中间成果 合作的努力。主要职能是促进项目负责人之间的科学互动， 作为核心领导者。行政部门将发挥领导作用，确保达到里程碑， 评估核心职能，修改科学目标，纳入任何新的合作者， 持续确定优先次序和重新分配资源的决定。关键决定将在协商中作出 与项目负责人和NIH的项目官员进行了交流。行政核心将向NIH提交年度报告。 行政核心将维持预算，并监督为满足计划所需的任何重新预算 目标.行政核心的生物统计部分将提供数据管理和统计支持 对于这三个项目。此外，生物统计部分将建立和维护适当的数据库， 根据调查人员的要求进行管理和分析。为了提供服务，以满足 分析挑战核心将包括促进必要的方法，以解决复杂的统计 在各种研究项目中遇到的问题。此外，提供临床医生之间的基本指标， 科学家和生物统计学家。拥有专门用于生物统计和数据管理需求的资源， 这里提出的研究将为所进行的研究的质量和生产力增加巨大的价值 研究者必须将这些信息正确地传播给科学界。