Role of MyD88 signaling in systemic inflammation and Alzheimer disease
MyD88 信号在全身炎症和阿尔茨海默病中的作用
基本信息
- 批准号:10611489
- 负责人:
- 金额:$ 50.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:3xTg-AD mouseAccelerationAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease patientAlzheimer&aposs disease riskAmyloid beta-ProteinAnimal ModelBacterial InfectionsBindingBone MarrowBrainCASP1 geneCell DeathCellsCentral Nervous SystemChronicCognitionCytoplasmic ProteinDataDementiaDepositionDevelopmentDiseaseDisease ProgressionEarly Onset Familial Alzheimer&aposs DiseaseEtiologyEventFunctional disorderGenetic RiskGenetic studyGoalsIL18 geneImmuneImmune responseIn VitroInflammagingInflammasomeInflammationInflammatoryInnate Immune ResponseInterleukin ActivationInterleukin-1 betaLate Onset Alzheimer DiseaseMYD88 deficiencyMeasuresMediatingMicrogliaMolecularMultiprotein ComplexesNerve DegenerationNeurofibrillary TanglesNeuronsPathogenesisPathogenicityPathologicPathologyPathway interactionsPatientsPeripheralPlayPreventivePreventive measureProductionProteinsRiskRoleSenile PlaquesSignal PathwaySignal TransductionSynapsesSystemTherapeuticVirus Diseasesabeta accumulationbrain parenchymacognitive functioncytokinedementia riskextracellularglial activationhyperphosphorylated tauin vivomarenostrinmild cognitive impairmentmouse modelneuroinflammationneuron lossneuropathologyprotein complexreconstitutionrisk variantsensorsexsystemic inflammatory responsetau Proteinstau aggregationtau-1
项目摘要
Project Summary / Abstract
The main pathological changes found in patients with Alzheimer’s disease (AD) are extracellular amyloid β (Aβ)
deposits in the brain parenchyma (amyloid plaques) and abnormal aggregates of hyperphosphorylated tau
protein in brain neurons (neurofibrillary tangles, NFTs). Amyloid plaques and NFTs are accompanied with chronic
inflammation characterized by activated microglia and increased levels of cytokines. Except a small subset of
early-onset familial AD cases, the causes for the vast majority of AD cases are unknown and satisfactory
therapeutic and preventive measures for AD are unavailable. Therefore, an urgent need exists to identify the
molecular mechanisms that increase the risk for the vast majority of AD cases and to develop the preventive and
therapeutic measures. Systemic inflammation promotes AD progression and even initiates microglial activation
and neurodegeneration. Indeed, recent genetic studies on late-onset AD have identified about a dozen genetic
risk variants that are highly expressed in microglia and involved in innate immune responses, highlighting the
importance of immune responses, particularly activated microglia, in the pathogenesis of late-onset AD. Aging
is the largest known risk factor for AD and is characterized by chronic, systemic inflammation (inflamm-aging).
Systemic inflammation caused by certain bacterial and viral infections is a strong risk factor of dementia, also.
Additionally, our preliminary data indicate that activation of NLRP3 inflammasome through the MyD88 signaling
pathway in microglia in the central nervous system (CNS) plays essential roles in the AD pathogenesis. In Aim
1, we will produce a microglia specific MyD88 deficiency in AD mouse models during aging and determine their
effect on Aβ and tau pathology and cognitive function. We further hypothesize that microglial MyD88 signaling
plays a predominant role in accelerating brain Aβ and tau pathology and neuroinflammation, which are induced
by chronic, systemic inflammation, in AD mouse models during aging. In Aim 2, we will determine the effects of
systemic LPS treatment on Aβ and tau pathology and cognition in AD mouse models with brain and peripheral
immune cell-specific MyD88 deficiency. In Aim 3, we will determine the age and sex dependent effects of LPS
treatment on NLRP3 inflammasome activation as disease mechanisms in the brain/microglia-specific and
peripheral immune cell-specific MyD88 deficient AD mouse models. Our hypothesis is that LPS-induced
systemic inflammation causes NLRP3 inflammasome activation in microglia via MyD88 signaling, leading to
exacerbation of AD-like pathophysiology in AD mouse models. The long term goals are to determine the role of
microglial MyD88/NLRP3 inflammasome signaling in the AD pathogenesis, to elucidate the molecular
mechanism underlying the increased AD risk associated with systemic inflammation and to develop new
preventive and therapeutic strategies for AD.
项目摘要/摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells.
- DOI:10.1371/journal.pone.0288497
- 发表时间:2023
- 期刊:
- 影响因子:3.7
- 作者:
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Ken-ichiro Fukuchi其他文献
Ken-ichiro Fukuchi的其他文献
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{{ truncateString('Ken-ichiro Fukuchi', 18)}}的其他基金
Role of MyD88 signaling in systemic inflammation and Alzheimer disease
MyD88 信号在全身炎症和阿尔茨海默病中的作用
- 批准号:
10456872 - 财政年份:2021
- 资助金额:
$ 50.13万 - 项目类别:
Role of MyD88 signaling in systemic inflammation and Alzheimer disease
MyD88 信号在全身炎症和阿尔茨海默病中的作用
- 批准号:
10314883 - 财政年份:2021
- 资助金额:
$ 50.13万 - 项目类别:
Altering immune tolerance in Alzheimer disease
改变阿尔茨海默病的免疫耐受性
- 批准号:
9979733 - 财政年份:2019
- 资助金额:
$ 50.13万 - 项目类别:
Role of extracellular vesicles in the high-fat diet-induced risk of Alzheimer disease
细胞外囊泡在高脂肪饮食诱发的阿尔茨海默病风险中的作用
- 批准号:
9385535 - 财政年份:2017
- 资助金额:
$ 50.13万 - 项目类别:
Role of diet-induced miR-34a in Alzheimer disease and dementia
饮食诱导的 miR-34a 在阿尔茨海默病和痴呆中的作用
- 批准号:
9225329 - 财政年份:2017
- 资助金额:
$ 50.13万 - 项目类别:
Role of the MyD88-independent pathway in Alzheimers disease
MyD88 独立通路在阿尔茨海默病中的作用
- 批准号:
8511261 - 财政年份:2013
- 资助金额:
$ 50.13万 - 项目类别:
Role of the MyD88-independent pathway in Alzheimers disease
MyD88 独立通路在阿尔茨海默病中的作用
- 批准号:
8676620 - 财政年份:2013
- 资助金额:
$ 50.13万 - 项目类别:
Catalytic and non-catalytic Ig gene delivery for Alzheimer's disease
阿尔茨海默病的催化和非催化 Ig 基因递送
- 批准号:
7963696 - 财政年份:2010
- 资助金额:
$ 50.13万 - 项目类别:
Catalytic and non-catalytic Ig gene delivery for Alzheimer's disease
阿尔茨海默病的催化和非催化 Ig 基因递送
- 批准号:
8081811 - 财政年份:2010
- 资助金额:
$ 50.13万 - 项目类别:
Innate immunity in Alzheimer's disease: Role of toll-like receptor signaling
阿尔茨海默氏病的先天免疫:Toll 样受体信号传导的作用
- 批准号:
7904117 - 财政年份:2009
- 资助金额:
$ 50.13万 - 项目类别:
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