Hydrogen Sulfide Regulation in Cardioprotection
Hydrogen Sulfide Regulation in Cardioprotection
批准号:
10610727
负责人:
DAVID JOSEPH LEFER
金额:
$54.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-05-11 至 2025-04-30
关键词:
AddressAttenuatedBiologicalBiological AvailabilityBiological ModelsBiological ProcessBiologyCardiovascular DiseasesCardiovascular systemChemicalsClinicalCytoprotectionDetectionDevelopmentDiabetes MellitusDiseaseDisease modelEvaluationExhibitsFluorescent ProbesFunctional disorderFutureGasesGoalsHeart DiseasesHeart failureHydrogen SulfideHypertensionImageInflammationKineticsKnowledgeLaboratoriesLibrariesLinkLiquid substanceMediatingMethodsModelingMonitorMyocardial InfarctionMyocardial IschemiaMyocardial Reperfusion InjuryOxidation-ReductionPathologicPeripheral Vascular DiseasesPharmacologyPhysiologyPlayProtocols documentationReactionRegulationReportingResearchRoleSamplingSeriesSignaling MoleculeSodium ChlorideSourceTherapeuticTimeTissuesVasodilationcardioprotectionclinically relevantdetection methodfluorophoreimprovednoveloxidationsensorsodium sulfidethioestertool
中文摘要
项目摘要
硫化氢是一种重要的信号分子,具有很强的细胞保护作用
心血管系统中的作用。目前的结果表明,硫化氢水平的调制
可能对血管扩张等多种疾病状态有潜在的治疗价值,
抗炎、抗氧化。然而,确切的作用机制仍然是
不清楚以及显示最佳保护所需的实际硫化氢浓度/流量
这些疾病模型还有待确定。这种知识的缺乏是一个主要的负担
在以硫化氢为基础的治疗的发展中。为了解决这个问题,研究工具可以
需要有效地检测生物样品中的硫化氢,特别是提供/去除生物样品中的硫化氢。
在这一应用中,我们计划开发用于检测硫化氢的高灵敏度荧光探针。
我们还将开发新型的硫化氢释放剂和清除剂。新的
将使用化学品来确定模型中用于心脏保护的最佳硫化氢配置文件
心肌缺血再灌注(MI/R)损伤与心力衰竭。这项研究将确立
指导硫化氢治疗发展的有用方案。
英文摘要
Project Summary
Hydrogen sulfide (H2S) is an important signaling molecule with potent cytoprotective
actions in cardiovascular systems. Current results indicate that modulation of H2S levels
could have potential therapeutic value for a number of disease states such as vasodilation,
anti-inflammation, and anti-oxidation. However, the exact mechanisms of action are still
unclear and the actual H2S concentration/flux needed to exhibit the optimal protection in
those disease models are to be determined. This lack of knowledge presents a major burden
in the development of H2S based therapy. To solve this problem, research tools that can
effectively detect H2S and specifically supply/remove H2S in biological samples are needed.
In this application we plan to develop highly sensitive fluorescent probes for H2S detection.
We will also develop novel H2S releasing agents and scavenging agents. The new
chemicals will be used to determine the optimal H2S profiles for cardioprotection in models of
myocardial ischemia/reperfusion (MI/R) injury and heart failure. This study will establish
useful protocols guiding the development of H2S therapy.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Hydrogen Sulfide Regulation in Cardioprotection
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批准号:10391506
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项目类别:
-
资助金额:$56.2万
-
财政年份:2020
-
负责人:DAVID JOSEPH LEFER
-
依托单位:
Hydrogen Sulfide Regulation in Cardioprotection
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批准号:10162413
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项目类别:
-
资助金额:$57.6万
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财政年份:2020
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负责人:DAVID JOSEPH LEFER
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依托单位:
Endogenous Hydrogen Sulfide Enzymes in Heart Failure
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批准号:10077584
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项目类别:
-
资助金额:$40.13万
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财政年份:2019
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负责人:DAVID JOSEPH LEFER
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依托单位:
Novel Mitochondrial DNA Repair Enzyme for Heart Failure
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批准号:9408031
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项目类别:
-
资助金额:$29.65万
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财政年份:2017
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负责人:DAVID JOSEPH LEFER
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依托单位:
Novel antifibrotic small molecules for the treatment of heart failure
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批准号:9142025
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项目类别:
-
资助金额:$30.0万
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财政年份:2016
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负责人:DAVID JOSEPH LEFER
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依托单位:
Novel Sulfide Releasing Agents for Ischemic Injury
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批准号:8629076
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项目类别:
-
资助金额:$38.86万
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财政年份:2014
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负责人:DAVID JOSEPH LEFER
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依托单位:
Novel Sulfide Releasing Agents for Ischemic Injury
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批准号:8889814
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项目类别:
-
资助金额:$3.11万
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财政年份:2014
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负责人:DAVID JOSEPH LEFER
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依托单位:
Nitrite Mediated Cardioprotection
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批准号:8289582
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项目类别:
-
资助金额:$25.42万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Nitrite Mediated Cardioprotection
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批准号:7900081
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项目类别:
-
资助金额:$38.75万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Nitrite Mediated Cardioprotection
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批准号:8835549
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项目类别:
-
资助金额:$12.94万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:8399050
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项目类别:
-
资助金额:$8.06万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:7754425
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项目类别:
-
资助金额:$38.75万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:8921357
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项目类别:
-
资助金额:$28.46万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Nitrite Mediated Cardioprotection
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批准号:8085943
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项目类别:
-
资助金额:$38.75万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:8207216
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项目类别:
-
资助金额:$38.36万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Nitrite Mediated Cardioprotection
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批准号:7742542
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项目类别:
-
资助金额:$38.75万
-
财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:7599368
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项目类别:
-
资助金额:$38.75万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
Cardioprotective Actions of Hydrogen Sulfide
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批准号:8011098
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项目类别:
-
资助金额:$38.75万
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财政年份:2009
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负责人:DAVID JOSEPH LEFER
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依托单位:
MECHANISMS OF MYOCARDIAL REPERFUSION INJURY--DIABETES
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批准号:6184820
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项目类别:
-
资助金额:$17.7万
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财政年份:1999
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负责人:DAVID JOSEPH LEFER
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依托单位:
Mechanism of Myocardial Reperfusion Injury in Diabetes
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批准号:6998480
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项目类别:
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资助金额:$24.23万
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财政年份:1999
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负责人:DAVID JOSEPH LEFER
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依托单位:
海外基金